On sexual desire systems and loss of libido [Part 1]

This is a place to post research you have done on the topic along with your conclusions.
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Meso
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by Meso »

Frog wrote:Very interesting, looking forward to part 2! Really appreciate all of your effort!
Thanks for your support and other patron's! It wouldn't be possible without your support guys!
kpavel wrote: So one question bothered me and just checked and found that In frontotemporal dementia mPFC is malfunctional.
https://www.ncbi.nlm.nih.gov/pubmed/24078043
FTD patients were described having sexually disinhibited behavior (unusual in their age). They are given same drugs as offenders, Even more experimental, like carbamazepine https://www.ncbi.nlm.nih.gov/pubmed/22217950
That makes sense. As I mentioned in the article, the PFC has an inhibitory effect on limbic areas. This is called the top-down control. So, when it's dysfunctional, the limbic system goes into an over-drive + you cannot control your impulses anymore. This leads to aberrant behaviors, such as compulsive hypersexuality.
kpavel wrote:Also recently found that in schizophrenia there's a poor functional connectivity between mPFC and amygdala leading to a problem with emotional control/recognition.
https://www.researchgate.net/publicatio ... _Disorders
The amygdala sends raw 'untagged' data to the mFPC. The latter analyses this raw data and puts a 'tag' or attaches an 'emotion' to it and sends it back to the limbic system. This is called bottom-up feedback. When this communication is disturbed, one can experience blunted affect and inability to recognize emotions, since they are raw, untagged data. This is also why people on high dose tonic dopaminergics can experience worsening of blunted affect and anhedonia, since tonic stimulation of dopamine receptors disrupts this communication + downregulates the receptors.
kpavel wrote:And in porn addiction striatum <<==>>mPFC?
Porn addiction is more complex than that. You can read more here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039517/
kpavel wrote:So are pssd sufferers more inhibited or disinhibited now? Where is additional breakpoint in BLA or nACC? Because I don't doubt that impulsivity existed earlier and doubt it is cured in pssd state.
It depends on the subtype of PSSD.
kpavel wrote:Also people report losing their ocd. Could it be related?
This has to do more with the hypoglutamatergic state most of us experience. There's a GABA-glutamate imbalance due to GR upregulation by antidepressants and other factors.
chemistry wrote:Interesting, some people report losing part of the sense of thirst or hunger as well. Great work meso
There is profound hypothalamic dysfunction in some patients, I assume.
naiverat wrote:Nice work. Funny how often estradiol/E2 is overlooked with regard to male libido, yet it appears to be the most vital component.
Yes, it's very vital but within limits. Inverse U-curve.
finities infinities wrote: When will you look at me?
Depression must be treated first before PSSD is addressed. Find an antidepressant that works for you. Also, you don't suffer from PSSD; your symptoms are triggered by antipsychotics. So, it's a different syndrome.
succubus76 wrote: This is very simplistic, but meaby high serotonin ir impairing androgens receptors. Or to much serotonin is binding antisexual 5ht receptors
Scientists have concluded that inhibitory systems of libido far overpower the excitatory systems. This means that disabling an inhibitory system would boost libido far more than activating an excitatory system. I will go much more in-depth regarding serotonin and other inhibitory systems later in the article.
PsychoGenesis wrote:is this why mirepristone works by upregulating d1 receptors??
I haven't looked into Mifepristone yet.
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finities infinities
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by finities infinities »

Mesolimbo- I take clomipramine 50 mg. This is SNRI, I'm untolerated other antidepressant, only clomipramine ,,slighty" increase my ,,human" emotion and motivation but not remove my weird thought, anhedonia, over-inhibition, hipervigilance.
And don't you think my carbamazepine PAWS mimics depression?
Have you read my recent posts about my thoughts and buspirone? I I once talked to people in hospital with depression. They didn't show such perceptions and thoughts as mine and anhedonia. Rather, they were about people who were very apathetic and depressed, grumpy, had their emotions preserved and were not dissociated. More similar behaviours have people with ,,schizophrenia" treatment antipsychotic- excess empathy, vulnearable, anxiety, anhedonia and more depressive symtom than peoples with depression.
I remember meeting a woman in a psychiatric hospital. She had a diagnosis of schizophrenia and ate risperidone, she showed very similar cognitive styles as I did. She was a sensitive, empathic good woman ( with evident dependance personality disorder and social anxiety, shyness) who experienced terrible things inside her head, she also had anhedonia.
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TalkingAnt
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by TalkingAnt »

Mesolimbo, great article, I am excited for the series. I think it can be a new starting point for theory and experimentation.

Also, can we please keep this thread on topic? This is really important research and we don't want to derail this discussion. Finite Infinities, I ask that you please keep your personal situation in your own thread. I understand you are in a dire situation, as are many on this forum, but what will do the most good for everyone is furthering the research.
Cured | PSSD 2012-2020 | Log thread
enriqueiglesias
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by enriqueiglesias »

Great article.

Regarding the Nucleus Accumbens, maybe that's why taking Omega 3 has often correlated with times of higher libido for me, as Omega 3 fatty acids are said to restore normal nucleus accumbens function somewhat.

Vitamin D is also good:
https://www.ncbi.nlm.nih.gov/pubmed/30144460

Generally, dopamine d1 function seems to be very important. (Maybe that explains some of St. John's Wort's acute function? Always wondered.)
finities infinities wrote: Risperidone is strong D2 antagonist, maybe upregulate my D2 and downregulate D1 and cause my symptoms 10 years ago. In herbpedia peoples wrote that D2 receptor is dissociative, separates from the outside world and D1 is euphoric receptor which work opposite to D2. JayR also wrote about D1- decrease social prejudice, anxiety and increase motivation, youthfull feeling and creativity.
Great point also. D2/1 dysregulation makes sense and could account for some of its many side-effects.
(Sulbutiamine is a known D1 antagonist, I just found Berberine is non-selective to D2/D1.)

Mesolimbo wrote:
finities infinities wrote: When will you look at me?
Depression must be treated first before PSSD is addressed. Find an antidepressant that works for you. Also, you don't suffer from PSSD; your symptoms are triggered by antipsychotics. So, it's a different syndrome.
Wow, nice...

TalkingAntColony wrote: Also, can we please keep this thread on topic? This is really important research and we don't want to derail this discussion. Finite Infinities, I ask that you please keep your personal situation in your own thread. I understand you are in a dire situation, as are many on this forum, but what will do the most good for everyone is furthering the research.
There are already lots of sideline-topics, which have nothing to do with libido.
Jaxx
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by Jaxx »

TalkingAntColony wrote: Also, can we please keep this thread on topic? This is really important research and we don't want to derail this discussion. Finite Infinities, I ask that you please keep your personal situation in your own thread. I understand you are in a dire situation, as are many on this forum, but what will do the most good for everyone is furthering the research.
There are already lots of sideline-topics, which have nothing to do with libido.[/quote]

Lets try to keep on-topic indeed, it will be positive for the quality of the discussions. Personal questions deserve another thread.
farside44
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by farside44 »

Hi Mesolimbo,

Do you plan on writing some sort of diagnostic guide? Something that walks you through how to evaluate the functioning of one's neurological system?

For example, you might write that if one takes cabergoline and experiences no improvement, then their XYZ pathway is probably functioning properly, therefore they should shift their focus to the ABC pathway, which they can evaluate by taking some other pharmaceutical. And so on until the problem is found by process of elimination.

You know what I mean? Something to guide one's diagnosis?
sovietxrobot
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by sovietxrobot »

farside44 wrote: For example, you might write that if one takes cabergoline and experiences no improvement, then their XYZ pathway is probably functioning properly, therefore they should shift their focus to the ABC pathway, which they can evaluate by taking some other pharmaceutical. And so on until the problem is found by process of elimination.
I have been wondering the same thing. If you try something and get a negative or null result- can you draw any inference from that?
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