On sexual desire systems and loss of libido [Part 1]

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Meso
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On sexual desire systems and loss of libido [Part 1]

Unread post by Meso »

Originally, I wanted to write one big article with all the details. It would have been 90+ min read. It's a LOT of info to digest for anyone, so I decided instead to cut the article in smaller parts, each part 10 min read give or take.

https://www.theresearchzone.com/post/lo ... ido-part-1
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Frog
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by Frog »

Very interesting, looking forward to part 2! Really appreciate all of your effort!
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kpavel
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by kpavel »

Cool text. Getting so much of systematic description in 10-15 minutes is very cool.

So one question bothered me and just checked and found that In frontotemporal dementia mPFC is malfunctional.
https://www.ncbi.nlm.nih.gov/pubmed/24078043
FTD patients were described having sexually disinhibited behavior (unusual in their age). They are given same drugs as offenders, Even more experimental, like carbamazepine https://www.ncbi.nlm.nih.gov/pubmed/22217950

Also recently found that in schizophrenia there's a poor functional connectivity between mPFC and amygdala leading to a problem with emotional control/recognition.
https://www.researchgate.net/publicatio ... _Disorders

And in porn addiction striatum <<==>>mPFC?

So are pssd sufferers more inhibited or disinhibited now? Where is additional breakpoint in BLA or nACC? Because I don't doubt that impulsivity existed earlier and doubt it is cured in pssd state.
Last edited by kpavel on Tue Sep 17, 2019 1:59 pm, edited 1 time in total.
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kpavel
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by kpavel »

Also people report losing their ocd. Could it be related?
chemistry
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by chemistry »

Interesting, some people report losing part of the sense of thirst or hunger as well. Great work meso
Brief Symptoms:
PE - Anhedonia, less emotions - Test Atrophy - Numb body - Lowered libido = ED
24/7 tension, stress. Worse with lack of sleep, hungry, ill
"Pure-O"
Visual Snow Syndrome + DP/DR + Tinnitus
Insomnia, Fatigue
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naiverat
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by naiverat »

Nice work. Funny how often estradiol/E2 is overlooked with regard to male libido, yet it appears to be the most vital component.
Fluoxetine Jan. '16 - Aug. 16'. Low libido, weak erections, CNS dysfunction, anhedonia

Windows on the following: Inositol, choline, NAC + Histidine, MSM, SJW, L-Arginine, Sildenafil, Naltrexone, boron
finities infinities
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by finities infinities »

Great article! I heard that libido is opposite to anxiety and empathy.
From what I understood, lowering dopamine in Nac and mPOA should induce my empathy. I always got worse after orgasm, I became very empathetic.
And it gave me food for thought as you wrote about the ratio D1: D2 in ovulation- I suspect that D1 increase libido lowered empathy and D2 increase empathy and my bad symptoms.
Risperidone is strong D2 antagonist, maybe upregulate my D2 and downregulate D1 and cause my symptoms 10 years ago. In herbpedia peoples wrote that D2 receptor is dissociative, separates from the outside world and D1 is euphoric receptor which work opposite to D2. JayR also wrote about D1- decrease social prejudice, anxiety and increase motivation, youthfull feeling and creativity.
When will you look at me?
Kpavel- I'm very surprised that carbamazepine is used to inhibited sexual behaviour, maybe it is used to create PAWS. I have carbamazepine PAWS, i remeber what increase 400 carbamazepine to 800 in summer 2017- this is very euphoric, strong motivation, emotional blunting, disinhibition like hipomania in bipolar with drymouth, constipation and pupil dilation, but tolerance developed quickly and decrease dose in autumn 2017 create strong persistant PAWS. Very dopamine release drug.
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succubus76
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by succubus76 »

Thanks meso for your efforts and support :D :D :D :D : D
naiverat wrote:Nice work. Funny how often estradiol/E2 is overlooked with regard to male libido, yet it appears to be the most vital component.
This is very simplistic, but meaby high serotonin ir impairing androgens receptors. Or to much serotonin is binding antisexual 5ht receptors
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by naiverat »

succubus76 wrote:Thanks meso for your efforts and support :D :D :D :D : D
naiverat wrote:Nice work. Funny how often estradiol/E2 is overlooked with regard to male libido, yet it appears to be the most vital component.
This is very simplistic, but meaby high serotonin ir impairing androgens receptors. Or to much serotonin is binding antisexual 5ht receptors
Oh, well, there are definitely other contributing factors to libido. I'm just saying, usually when we think of low libido in males, it's immediately attributed to low testosterone while estradiol is seem as "the feminine hormone." That said, you need enough free T to aromatize to E2 as well.
Fluoxetine Jan. '16 - Aug. 16'. Low libido, weak erections, CNS dysfunction, anhedonia

Windows on the following: Inositol, choline, NAC + Histidine, MSM, SJW, L-Arginine, Sildenafil, Naltrexone, boron
PsychoGenesis
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Re: On sexual desire systems and loss of libido [Part 1]

Unread post by PsychoGenesis »

is this why mirepristone works by upregulating d1 receptors??
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