Thanks for your support and other patron's! It wouldn't be possible without your support guys!Frog wrote:Very interesting, looking forward to part 2! Really appreciate all of your effort!
That makes sense. As I mentioned in the article, the PFC has an inhibitory effect on limbic areas. This is called the top-down control. So, when it's dysfunctional, the limbic system goes into an over-drive + you cannot control your impulses anymore. This leads to aberrant behaviors, such as compulsive hypersexuality.kpavel wrote: So one question bothered me and just checked and found that In frontotemporal dementia mPFC is malfunctional.
https://www.ncbi.nlm.nih.gov/pubmed/24078043
FTD patients were described having sexually disinhibited behavior (unusual in their age). They are given same drugs as offenders, Even more experimental, like carbamazepine https://www.ncbi.nlm.nih.gov/pubmed/22217950
The amygdala sends raw 'untagged' data to the mFPC. The latter analyses this raw data and puts a 'tag' or attaches an 'emotion' to it and sends it back to the limbic system. This is called bottom-up feedback. When this communication is disturbed, one can experience blunted affect and inability to recognize emotions, since they are raw, untagged data. This is also why people on high dose tonic dopaminergics can experience worsening of blunted affect and anhedonia, since tonic stimulation of dopamine receptors disrupts this communication + downregulates the receptors.kpavel wrote:Also recently found that in schizophrenia there's a poor functional connectivity between mPFC and amygdala leading to a problem with emotional control/recognition.
https://www.researchgate.net/publicatio ... _Disorders
Porn addiction is more complex than that. You can read more here:kpavel wrote:And in porn addiction striatum <<==>>mPFC?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039517/
It depends on the subtype of PSSD.kpavel wrote:So are pssd sufferers more inhibited or disinhibited now? Where is additional breakpoint in BLA or nACC? Because I don't doubt that impulsivity existed earlier and doubt it is cured in pssd state.
This has to do more with the hypoglutamatergic state most of us experience. There's a GABA-glutamate imbalance due to GR upregulation by antidepressants and other factors.kpavel wrote:Also people report losing their ocd. Could it be related?
There is profound hypothalamic dysfunction in some patients, I assume.chemistry wrote:Interesting, some people report losing part of the sense of thirst or hunger as well. Great work meso
Yes, it's very vital but within limits. Inverse U-curve.naiverat wrote:Nice work. Funny how often estradiol/E2 is overlooked with regard to male libido, yet it appears to be the most vital component.
Depression must be treated first before PSSD is addressed. Find an antidepressant that works for you. Also, you don't suffer from PSSD; your symptoms are triggered by antipsychotics. So, it's a different syndrome.finities infinities wrote: When will you look at me?
Scientists have concluded that inhibitory systems of libido far overpower the excitatory systems. This means that disabling an inhibitory system would boost libido far more than activating an excitatory system. I will go much more in-depth regarding serotonin and other inhibitory systems later in the article.succubus76 wrote: This is very simplistic, but meaby high serotonin ir impairing androgens receptors. Or to much serotonin is binding antisexual 5ht receptors
I haven't looked into Mifepristone yet.PsychoGenesis wrote:is this why mirepristone works by upregulating d1 receptors??