kpavel wrote: ↑Sun May 10, 2020 6:08 pm
Hey folks, yesterday the user
cdraham made a very interesting hypothesis in Reddit. And I have to inform you, I was collecting scientific reports on this topic since late November. I had symptoms of something like heart angina, postural orthostatic tachycardia syndrome and mental fatigue mainly since my bad luck with ginger. And as a result of my searches I started experimenting with mitochondrial supplements with a great success, especially since the 18th of March, in those home isolation days when I could firmly say there's no more symptoms, no fatigue, and my heart rhythm is normal when I walk or stand, and I just feel normal.
It happened because I managed to improve my mitochondrial health. I think, with pharmaceutical drugs, especially with SSRI drugs (or direct serotonin precursor 5-HTP) we induce a mitochondrial fragility or make it worse. That type of damage alone can entail a cascade of events which caused most of our symptoms including anhedonia or ed.
So how important is mitochondrial stability in modern diseases?
Mitochondrias are complex cell energy units which can even move between cells and every major illness is studied in their context for more than 10-15 years. It's a serious trend. For a short introduction watch this interview with Dr. Peter Bongiorno.
https://youtu.be/usd1kofEg2w
There are also so called inherited rare mitochondrial diseases.
For example see
https://youtu.be/8rUTRaRD7AM
What are the possible symptoms of mitochondrial malfunction?
Here they are:
BRAIN
Developmental delays, Migraines, Seizures, Dementia, Autistic Features, Atypical cerebral palsy,
Neuro-psychiatric disturbances, Intellectual Disabilities, Strokes
NERVES
Weakness (may be intermittent), Fainting, Absent reflexes,
Neuropathic pain, Dysautonomia, Temperature Instability
MUSCLES
Weakness, Irritable bowel syndrome, Gastroesophogeal reflux,
Cramping, Diarrhea or constipation, Hypotonia,
Gastrointestinal problems, Pseudo-obstruction, Dysmotility
KIDNEYS
Renal tubular acidosis or wasting
HEART
Cardiac conduction defects (heart blocks), Cardiomyopathy
LIVER
Hypoglycemia (low blood sugar), Liver failure,
EARS & EYES
Visual loss and blindness, Optic atrophy, Acquired strabismus,
Ptosis, Ophthalmoplegia, Retinitis pigmentosa,
Hearing loss, Deafness,
PANCREAS & OTHER GLANDS
Diabetes, Exocrine Pancreatic Failure, Parathyroid failure
SYSTEMIC
Failure to gain weight, Unexplained vomiting, Respiratory problems,
Fatigue, Short stature
https://www.umdf.org/what-is-mitochondr ... -symptoms/
How a SSRI drug can damage mitochondrias?
We can't know all possbile reasons but there are lots of genes that could be affected in theory. Scientists did direct studies for antidepressants (citalopram, fluoxetine etc) and also we can expect cellular mechanisms of 5-HT receptors signalling to do certain destructive changes. For example here is the list of drugs that damage mitochondrias in different ways.
https://www.medsafe.govt.nz/profs/PUArt ... oAvoid.htm
Find fluoxetine. I found out potential mechanisms for both MRCI and MRCV but I'm almost sure restoring MRCI is the most promising way to go.
Which factors can improve mitochondrial function?
A lot of them: activities, in food, drugs, plants. That's the big question. But there are the most prominent ones. All of them are supplements of orthomolecular kind.
I addition, here's an interesting clue on possible cognition issues reasons.
https://en.wikipedia.org/wiki/Encephalopathy
Do you know how I came to all these findings? Well if you remember, on the old hosting one guy had claimed he was almost cured with Lady's Mantle plant. I tried it and mentioned I felt more tension down there. So what happened next is reading some of stuff which if I'm not mistaken was in Meso's posts. I decided to try gelatin powder because it has lots of glycine. Next day I woke up in a foggy state and several hours later I felt strong spasms in groin area. This lasted for more than a week. I didn't know what to do and what was that until I found out that glycine receptors are involved in muscle spasticity and myoclonus. Glycine also seems to harm orexin neurons in brain, insufficiency of orexin, I thought, was a cause of anhedonia, sleepiness and even sleep paralysis. So I thought how would I upregulate GLYT2 transporter or how would I block glycine alpha1 receptor? First I decided to use beta-carbolines (found in coffee or Harmala). It really helped with spasms. I know it all sounds crazy without tests etc. But that's what I was experiencing so who knows. And soon I began to work with my mitochondrias, with great success.
If you are interested in what molecular mechanisms are behind my theory I am in a stage of preparing a short scientific example explanation of how serotonin drugs can affect sexual function through mitochondria and other mechanisms. Just have to repeat selected materials and formulate the logic in normal English (that's a more difficult part for me). Questions?