PSSD can be triggered by mitochondrial instability

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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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fellow1 wrote: Thu May 28, 2020 7:41 am How do you take PQQ ? empty stomach or with food ?
When I took it regularly, and it was more than 2 years ago, I just took it in the morning, then breakfast in several minutes. Acute effects were really improved mood, more energy, And in that month I noticed that "reconnection" effect. Now I have a bottle of it, but took only several capsules for this calendar year. Of note cocoa has probably best value of PQQ per 100 g.
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Re: PSSD can be triggered by mitochondrial instability

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kpavel wrote: Thu May 28, 2020 9:22 am
fellow1 wrote: Thu May 28, 2020 7:41 am How do you take PQQ ? empty stomach or with food ?
When I took it regularly, and it was more than 2 years ago, I just took it in the morning, then breakfast in several minutes. Acute effects were really improved mood, more energy, And in that month I noticed that "reconnection" effect. Now I have a bottle of it, but took only several capsules for this calendar year. Of note cocoa has probably best value of PQQ per 100 g.
So basically your latest recovery is not related to sexual symptoms, because you were already functioning normally ? And pqq helped you in the past, but the most recent recovery helped you with mental problems ? (anhedonia etc.) Sorry it's just not very clear.
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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I had no serious problems with getting full erections, but didn't have pleasurable feeling, this notably improved and all is spontaneous now, however, the major thing achieved is in motivation, energy, reward, euphoria, maybe empathy. Like in my signature.)
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Re: PSSD can be triggered by mitochondrial instability

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kpavel wrote: Thu May 28, 2020 9:37 am I had no serious problems with getting full erections, but didn't have pleasurable feeling, this notably improved and all is spontaneous now, however, the major thing achieved is in motivation, energy, reward, euphoria, maybe empathy. Like in my signature.)
I see, thanks. And were you taking soya lecithin ? or some other form ?
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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Life Extension jar, soya lecithin from iHerb.
JP1985
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Re: PSSD can be triggered by mitochondrial instability

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kpavel wrote: Mon May 11, 2020 3:27 am
cdraham wrote: Sun May 10, 2020 6:32 pm Very interesting indeed, may I ask what your symptoms before were? How was your reaction to alcohol, recreational drugs?

What exactly did you do to help your mitochondria? Do you feel 100% cured of your PSSD now?

btw: the member helvy improved on HBOT initially before his crash, that might have boosted mitochondria function

I did some research and came across 10 pass ozone therapy, something I might try.
Yes, really, I feel like a cured man, it was something very notable happening and things are still improving. First of all it is a feeling that obstacles in life is not something to worry about. I stopped doubting a lot, sort of an alpha-male (yes, I can, it's not difficult) feeling inside (so it's only partly about testosterone, more about dopamine). Also you know, when you suspect a heart condition life becomes very miserable. Now I can do things till 1 am every day if I want.

Another symptom is I began sweating normal and I'm less restless. I had very little sweat, my sleep was intermittent, I didn't feel a pleasure to sleep a little more. Also my hands were in increased tonus/tension state, especially veins were very prominent on them several times in a day. When I walked my heart rate was more than 100 bpm, and when I stopped it didn't calm for a long time, so called intolerance to exercise, I guess. So this all was a lot of discomfort, stopping any pleasure in life. Also I can read texts on screen and not return to repeat, like I did in the worst times, but see the whole picture from page.

Interesting fact, I began playing computer games a lot, it's not a meh now. I feel it is easier to become an addict now). I drink coffee more than ever. Watching dreams every night 8-) , they are colorful, sometimes erotic, I can be almost woken up and continue dreaming if you understand what it feels like. My morning erections are everyday. I also noticed my balls have grown. Strange coincidence. Also my laughing is more spontaneous and natural.

I don't use drugs, it's not legal here and really dangerous. Not worth it. I react to wine well, increased mood, even more than from caffeine-containing drinks.

I combine several supplements everyday, but believe the most useful were niacinamide, d-ribose, lecithin, resveratrol and carnitine. Probably PQQ, but not now, 2 years ago my connecton feeling from brain to penis was restored while taking pqq.

Oxygen/ozone can be helpful for mitochondrias but obviously in the right concentration.
https://www.ncbi.nlm.nih.gov/pubmed/25828268
https://www.ncbi.nlm.nih.gov/pubmed/31827546
https://www.ncbi.nlm.nih.gov/pubmed/25701186
https://www.ncbi.nlm.nih.gov/pubmed/29022413
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
https://www.cell.com/cell/fulltext/S009 ... 13)01521-3
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but its causes are debated. We show that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits. We trace the cause to an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication that is induced by a decline in nuclear NAD+ and the accumulation of HIF-1α under normoxic conditions, with parallels to Warburg reprogramming. Deleting SIRT1 accelerates this process, whereas raising NAD+ levels in old mice restores mitochondrial function to that of a young mouse in a SIRT1-dependent manner. Thus, a pseudohypoxic state that disrupts PGC-1α/β-independent nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age, a process that is apparently reversible.
Hello mate, I like the sound of this but just decided to start taking St Johns Wort.. Do you think I could add the supplements you took to it? Or would any of them cause me problems mixing them? Mostly wanting to improve penis sensation, feelings of pleasure and energy levels would be great, Thanks JP
Last pill March 2019 - Citalopram for 7 years
Numbed penis and weak orgasm
Fatigue
Slightly blunted
Dizziness (this has improved a lot in the last 6 months)
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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From technical info on SJW I saw hyperforin can be a potent PXR activator. Also one study says PXR can interact with CPT1a (inhibit), a carnitine related enzyme.
Both sjw and alc are used for depression. Also hyperforin can change SIRT1 from studies. But depression is such a poorly determined word. I would test sjw separately, at least for the first time, to understand the effect. And of course SJW has more constituents that could do something.
JP1985
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Re: PSSD can be triggered by mitochondrial instability

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Would you say doing your supplement combination is safer or SJW alone? I’m worried to make it worse. Here’s where I am roughly..

Penis sensation when touched 5/10
Orgasm 6/10
Energy 3/10
Enjoyment of things 6/10
Happiness 6/10
Anxiety 5/10

A lot i’d love to improve on but also a lot to lose. If SJW has a good chance of making me worse then I might not bother. It’s the perika brand I’ve got (haven’t taken it yet)
Last pill March 2019 - Citalopram for 7 years
Numbed penis and weak orgasm
Fatigue
Slightly blunted
Dizziness (this has improved a lot in the last 6 months)
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kpavel
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Re: PSSD can be triggered by mitochondrial instability

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JP1985 wrote: Sat Jun 06, 2020 6:28 am Would you say doing your supplement combination is safer or SJW alone? I’m worried to make it worse. Here’s where I am roughly..

Penis sensation when touched 5/10
Orgasm 6/10
Energy 3/10
Enjoyment of things 6/10
Happiness 6/10
Anxiety 5/10

A lot i’d love to improve on but also a lot to lose. If SJW has a good chance of making me worse then I might not bother. It’s the perika brand I’ve got (haven’t taken it yet)
You can find claims of side effects for all of vitamins, aminoacids etc. But speaking for myself, no longterm worsening in anything happened in me since this winter. I know that active form of vitamin b6 makes me wired for some reason, zinc too. I actually took SJW in 2014 but also many other things, so can't judge here.
Based on your grades above several of the supplements are good for anxiety (including my experience). Stress resilience. Sensation isn't super, but ok. Energy much improved. Good appetite. Good orgasm.
JP1985
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Re: PSSD can be triggered by mitochondrial instability

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I will give it a try I think, thanks for your help 👍
Last pill March 2019 - Citalopram for 7 years
Numbed penis and weak orgasm
Fatigue
Slightly blunted
Dizziness (this has improved a lot in the last 6 months)
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