Good Guy Histamine & Possible Role In PSSD

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Meso
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Good Guy Histamine & Possible Role In PSSD

Unread post by Meso »

This is my blog post about histamine's role in PSSD:
https://www.theresearchzone.com/post/hi ... -role-pssd

Hope you find it a helpful read
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magnilo
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Re: Good Guy Histamine & Possible Role In PSSD

Unread post by magnilo »

interesting article! thanks!
sleepiness has always characterized my pssd, so much so that all the options ive tried had to be stimulants.
i did not know about pitolisant! apparently its available in my country since a couple of years! time to give that a shot :)
Thomas
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Re: Good Guy Histamine & Possible Role In PSSD

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Meso wrote: Tue Dec 15, 2020 11:55 pm This is my blog post about histamine's role in PSSD:
https://www.theresearchzone.com/post/hi ... -role-pssd
Perhaps this discrepancy can be solved by reading another study [8] that shows that H1 antagonism initially (acutely) enhances dopamine release, but dopamine receptor downregulation occurs soon after (i.e. after chronic H1 antagonism). It means that H1 antagonists, as well as low histamine states, might facilitate dopamine release initially but end up blunting limbic dopamine signaling later on through downregulation, which makes sense from an adaptive point of view.
Interesting.
Do you think this could explain what happened to me?
1) I had my (only and) first "window" a few days after starting atarax (H1 antagonist)
2) A few weeks later it was gone? (in waves)
Last edited by Thomas on Wed Jan 06, 2021 2:20 pm, edited 1 time in total.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
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Meso
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Re: Good Guy Histamine & Possible Role In PSSD

Unread post by Meso »

Thomas wrote: Tue Jan 05, 2021 11:35 am Interesting.
Do you think this could explain what happened to me?
1) I had my (only and) first "window" a few days after starting atarax (H1 antagonist)
2) A few weeks later is was gone? (in waves)
Sounds plausible. Atarax is fairly selective.
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succubus76
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Re: Good Guy Histamine & Possible Role In PSSD

Unread post by succubus76 »

I wish I was a pharmacist like you, but is to much to study 🥺
Thomas
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Re: Good Guy Histamine & Possible Role In PSSD

Unread post by Thomas »

Meso wrote: Tue Jan 05, 2021 2:44 pm
Thomas wrote: Tue Jan 05, 2021 11:35 am Interesting.
Do you think this could explain what happened to me?
1) I had my (only and) first "window" a few days after starting atarax (H1 antagonist)
2) A few weeks later is was gone? (in waves)
Sounds plausible. Atarax is fairly selective.
And do you think this could help to draw any conclusions about my PSSD and what could help me?
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
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