This is my blog post about histamine's role in PSSD:
https://www.theresearchzone.com/post/hi ... -role-pssd
Hope you find it a helpful read
Good Guy Histamine & Possible Role In PSSD
Good Guy Histamine & Possible Role In PSSD
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Re: Good Guy Histamine & Possible Role In PSSD
interesting article! thanks!
sleepiness has always characterized my pssd, so much so that all the options ive tried had to be stimulants.
i did not know about pitolisant! apparently its available in my country since a couple of years! time to give that a shot
sleepiness has always characterized my pssd, so much so that all the options ive tried had to be stimulants.
i did not know about pitolisant! apparently its available in my country since a couple of years! time to give that a shot
Re: Good Guy Histamine & Possible Role In PSSD
Interesting.Meso wrote: ↑Tue Dec 15, 2020 11:55 pm This is my blog post about histamine's role in PSSD:
https://www.theresearchzone.com/post/hi ... -role-pssdPerhaps this discrepancy can be solved by reading another study [8] that shows that H1 antagonism initially (acutely) enhances dopamine release, but dopamine receptor downregulation occurs soon after (i.e. after chronic H1 antagonism). It means that H1 antagonists, as well as low histamine states, might facilitate dopamine release initially but end up blunting limbic dopamine signaling later on through downregulation, which makes sense from an adaptive point of view.
Do you think this could explain what happened to me?
1) I had my (only and) first "window" a few days after starting atarax (H1 antagonist)
2) A few weeks later it was gone? (in waves)
Last edited by Thomas on Wed Jan 06, 2021 2:20 pm, edited 1 time in total.
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
Symptoms: sexual & emotional numbness
Re: Good Guy Histamine & Possible Role In PSSD
Sounds plausible. Atarax is fairly selective.
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- succubus76
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Re: Good Guy Histamine & Possible Role In PSSD
I wish I was a pharmacist like you, but is to much to study
Re: Good Guy Histamine & Possible Role In PSSD
And do you think this could help to draw any conclusions about my PSSD and what could help me?
Escitalopram, 10mg/day, Jan-May 2019. Fluoxetine, May-Sept 2019. Mirtazapine 7,5mg/day, November 2019-January 2020. Escitalopram, 5mg/day, Feb-May 2020.
Symptoms: sexual & emotional numbness
Symptoms: sexual & emotional numbness
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