PSSD in 2021 | Melcangi Study Info, Future Research and Activism

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Meso
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Re: PSSD in 2021 | Melcangi Study Info, Future Research and Activism

Unread post by Meso »

Although I highly disagree with the notion that neurosteroids are involved in PSSD, since, unlike Paroxetine, many SRIs don't increase allopregnanolone yet still trigger full-blown PSSD. I still believe this study might be the window we need into getting PSSD more recognized within the research community and spark some interest in further research into the condition.
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Bear
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Re: PSSD in 2021 | Melcangi Study Info, Future Research and Activism

Unread post by Bear »

Thank you to everybody who donated, and especially to JP1985 for his brilliant offer this week!
MarathonMan
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Re: PSSD in 2021 | Melcangi Study Info, Future Research and Activism

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Target 30k . come on guys
JLo22
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Re: PSSD in 2021 | Melcangi Study Info, Future Research and Activism

Unread post by JLo22 »

made a small donation yesterday for the new target of 30,000
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anacleta
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Re: PSSD in 2021 | Melcangi Study Info, Future Research and Activism

Unread post by anacleta »

In the course of this week there has been the largest donation ever seen, over 7000 euros, it's fantastic, thank you very much whoever you are, show yourself! thank you!
https://www.gofundme.com/f/27l8qmes5c
Frog
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Re: PSSD in 2021 | Melcangi Study Info, Future Research and Activism

Unread post by Frog »

Has anyone got any updates on how the study is going?
JLo22
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Re: PSSD in 2021 | Melcangi Study Info, Future Research and Activism

Unread post by JLo22 »

Dr. Melcangi is working on his first pssd paper from the money raised. He said it should be released some time this summer. The only thing he mentioned he was happy with results.
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anacleta
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Re: PSSD in 2021 | Melcangi Study Info, Future Research and Activism

Unread post by anacleta »

In July 2021 we finally got to know the interesting results of the study on PSSD carried out so far by the team from the University of Milan - Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Eva Falvo, Donatella Caruso, Roberto C. Melcangi.

"Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis"

Full text (link valid until 14 September 2021): https://authors.elsevier.com/c/1dTfu15hUdTGgL

The results show that there are alterations in the levels of various neurosteroids in different sites of the nervous system of rats administered the SSRI paroxetine, during treatment and 30 days after withdrawal. This is evidence of persistent biological changes caused by the SSRI and advances the hypothesis that its action on neurosteroids may be a likely pharmacological target.

However, it is not yet clear whether these alterations are the same as those that may cause symptoms of persistent sexual (sometimes also emotional and cognitive) dysfunction in some people who have previously used SSRIs/SNRIs.

However, the team is well motivated to continue research in order to better understand the underlying mechanisms of the syndrome, which is necessary for the identification of a valid treatment. Once again, our support is crucial through crowdfunding, to which we can contribute with donations at the GoFund link that has been opened for this very purpose: https://www.gofundme.com/f/27l8qmes5c
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