Estrogen receptor - Androgens - Progesterone & steroids / SJW

This is a place to post research you have done on the topic along with your conclusions.
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Wicksy1995
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Estrogen receptor - Androgens - Progesterone & steroids / SJW

Unread post by Wicksy1995 »

Mostly unsuccessful with trt as well as higher doses. I am better off on trt but in no way feels as if I am treating the route of the dysfunction - still cannot see any veins in my entire body/arms even with Cialis and nitric boosters. I’ve used Test before I tried SSRIs and it was extremely effective whereas now the results seem like they are unable to be tapped into due to the vascular/cardio dysfunction that comes with PSSD. I am thinking of trying nandrolone or trenbolone as an adjunct in order to upregulate both the androgen and estrogen receptor - these compounds do this through a sort of progestogenic mechanism that I’m going to delve into further. I’ve come across a few reports of low dose tren curing/reversing certain PSSD subtypes and given that I’ve been suffering for 3 years I’m willing to give it a go. I had a recent setback due to St johns Wort - the first 2-3 days were amazing - and then I was having non-stop reflux and migraines. It also seemed to affect my estrogen levels (subjectively) and after each testosterone injection, my anxiety levels would skyrocket. Apparently, it takes up to 2 weeks for SJW to completely clear the system so I am hoping to god I revert to pre SJW for the estrogenic disruption to clear. " St. John's wort (SJW) is a known strong inducer of the cytochrome P450 (CYP) 3 A4 enzyme, " I think this underlies its estrogenic/progestogenic interaction with my TRT.

Also - estrogen is said to normalize SERT expression resulting in reduced systemic 5HT and desensitized 1A - progesterone is thought to be an antagonist to estrogen 🧐🤨

Thoughts on adding Low dose tren roughly 100mg per week for 6 weeks to upregulate ERa/AR?
CN9
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Re: Estrogen receptor - Androgens - Progesterone & steroids / SJW

Unread post by CN9 »

you tried tren?
Area1255_2021
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Re: Estrogen receptor - Androgens - Progesterone & steroids / SJW

Unread post by Area1255_2021 »

Correct nNOS. As written in this post below. Androgens won't do anything without correcting the central nitric oxide dysfunction caused by PSSD.
CN9 wrote: Sun Aug 15, 2021 10:05 am Hello everyone,

I have no qualified knowledge on this field, so can anybody see a useful hypothesis behind the title?

Since my PSSD I suffer from bronchospasms after meals, expecially after fatty meals. After many years of suffering after every meal and the incompetence of many doctors, I tried salbutamol (aerosol spray) and it gave me a big relief from this constitution.
So I got me some ventolin (salbutamol as tabs, 8 mg per day). I'm not sure, if the agonism of the beta-2-receptors of my bronchial tubes was enough (by the spray) or if ventolin gave me an extra relaxation of my "feeling of tightness" but my heart palpitations and my Bronchitis or asthma, whatever it is, don't bother me anymore. Except for now, when I started eating daily beef jerkys (these ones: https://www.youtube.com/watch?v=c-LAqzSgneY ). After eating one, I get those feelings back, despite a 4 mg of salbutamol. Only the spray helps afterwards, but slight palpitations and a pressure on the chest remains. This took me to a quick google research, what made me also come here and ask you guys, if you see any connection to (my) pssd?

Tadalafil or sildenafil also don't really help with erections. #

I have high blood pressure, my sodium is at the lowest end, and my cholesterol is high.

What if the root cause of our pssd leads to a disfunction of metabolism of Nitrites and fats or what the f*ck ever!?

However, I'm sure, there is a connection between those symptoms, my weak erections (which got much better, although I can't tell really why), the feeling of less masculinity (although I lift very heavy and being a big guy (110 kg, 174 cm, upperarm of 50 cm, 290 kg deadlifts, 220 kg squats, ... and being natural from day one (germany natural)), less feeling pump, having disproportionate much belly fat since setraline, which I can't get rid off, fatty/oedematous skin at the limbs and belly, less urination (even if I drink... I used to urinate every 10 minutes, when I was very drunk... now, there is almost no change)...
I reinstated escitalopram last year in may, I experimented with different dosis (2,5; 5; 10; 15) for several month and since nov. 20 I took only 2,5 mg or even just 1,25 mg. I tapered off once for 2 weeks(?) and I'm drug-free for a week now... my belly fat became more aqueous again, and I feel like, my palpitations got more noticeable (but this can be due to being more alert than on a ssri.) ... however, what if there is a connection? Can we localise the serotonin receptor backwards by these symptoms?

Of course, this is only a spontaneous and lazy observation but I know, that we have many well educated guys here, who can probably explain all this with very less effort or... it leads to a valid theory.
The root cause of PSSD could be nNOS-nitric oxide dysfunction; it cuts off the signals to the hypothalamus, dampens/weakens/makes insignificant those networks - decreases Androgen sensitivity and cuts off normal function of Dopamine. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333763/) You need to get your salt levels up, take 1 teaspoon of Salt/Sodium per day; https://pubmed.ncbi.nlm.nih.gov/7510737/

...as far as Erections; add Pomegranate Juice to the Cialis. Drink Pomegranate juice (non-concentrate) 3-4 8 oz cups per day: https://pubmed.ncbi.nlm.nih.gov/27785815/
...It restores nNOS.
Also - Histamine is central in nNOS - it stimulates cAMP which regulates nNOS; PSSD is VERY STRONGLY a LOW histamine disorder...
...but you have to correct the deficit in nNOS proteins & nitric oxide signaling along with it or Histamine won't fire in the "right/correct" areas of the Brain/Penis.
ErgogenicHealth
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Re: Estrogen receptor - Androgens - Progesterone & steroids / SJW

Unread post by ErgogenicHealth »

Be super careful with TREN.... You're aware of all the risks right?
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Maxxx17
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Re: Estrogen receptor - Androgens - Progesterone & steroids / SJW

Unread post by Maxxx17 »

You know about all the risks and side effects, don't you? Please be careful with this. And consult a specialist about the dose. As I was quite cautious in my time in this regard. I got side effects in the form of poor potency. Now I have to remedy the situation with supertest 450 to get some relief.
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