Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

This is a place to post research you have done on the topic along with your conclusions.
Area1255_2021
Posts: 168
Joined: Sun Aug 15, 2021 4:45 pm

Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Area1255_2021 »

Proc Natl Acad Sci U S A
. 2012 Oct 9;109(41):16624-9. doi: 10.1073/pnas.1213790109. Epub 2012 Sep 24.
Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection.
K Joseph Hurt 1, Sena F Sezen, Gwen F Lagoda, Biljana Musicki, Gerald A Rameau, Solomon H Snyder, Arthur L Burnett
Affiliations expand
PMID: 23012472 PMCID: PMC3478647 DOI: 10.1073/pnas.1213790109
Free PMC article
Abstract
Nitric oxide (NO) generated by neuronal NO synthase (nNOS) initiates penile erection, but has not been thought to participate in the sustained erection required for normal sexual performance. We now show that cAMP-dependent phosphorylation of nNOS mediates erectile physiology, including sustained erection. nNOS is phosphorylated by cAMP-dependent protein kinase (PKA) at serine(S)1412. Electrical stimulation of the penile innervation increases S1412 phosphorylation that is blocked by PKA inhibitors but not by PI3-kinase/Akt inhibitors. Stimulation of cAMP formation by forskolin also activates nNOS phosphorylation. Sustained penile erection elicited by either intracavernous forskolin injection, or augmented by forskolin during cavernous nerve electrical stimulation, is prevented by the NOS inhibitor L-NAME or in nNOS-deleted mice. Thus, nNOS mediates both initiation and maintenance of penile erection, implying unique approaches for treating erectile dysfunction.

FORSKOLIN RAISES CYCLIC AMP

Mol Pharmacol
. 1982 Jul;22(1):109-15.
Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes
I Litosch, T H Hudson, I Mills, S Y Li, J N Fain
PMID: 6289066
Abstract
Forskolin increased cyclic AMP accumulation in isolated adipocytes and markedly potentiated the elevation of cyclic AMP due to isoproterenol. In adipocyte membranes, forskolin stimulated adenylate cyclase activity at concentrations of 0.1 microM or greater. Forskolin did not affect the EC50 for activation of adenylate cyclase but did increase the maximal effect of isoproterenol. Neither the soluble nor particulate low-Km cyclic AMP phosphodiesterase activity was affected by forskolin. Low concentrations of forskolin (0.1-1.0 microM), which significantly elevated cyclic AMP levels, did not increase lipolysis, whereas similar increases in cyclic AMP levels due to isoproterenol elevated lipolysis. Forskolin did not inhibit the activation of triacylglycerol lipase by cyclic AMP-dependent protein kinase or the subsequent hydrolysis of triacylglycerol. Higher concentrations of forskolin (10-100 microM) did increase lipolysis. Both the increased cyclic AMP production and lipolysis due to forskolin were inhibited by the antilipolytic agents insulin and N6-(phenylisopropyl)adenosine. Hypothyroidism reduced the ability of forskolin to stimulate cyclic AMP production and lipolysis. These results indicate that forskolin increases cyclic AMP production in adipocytes through an activation of adenylate cyclase. Lipolysis is activated by forskolin but at higher concentrations of total cyclic AMP than for catecholamines.
Charm the Snake
Posts: 63
Joined: Thu Apr 27, 2017 6:47 pm
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Charm the Snake »

This stack has given me pre-PSSD erections, both in quality and sustainability and other benefits. Taking cialis daily along with the other stuff.
The sensitivity of the glans is also much better.
Frequent random erections.
It also affects my chapped lips (Nitrous oxide related?)
I am satisfied.
I need a stack that will heal the nervous system as well. I experience little joy in life and my head feels disconnected. The disorder appears to be immunological in nature stemming from nervous system dysregulation.
My face is red and swells and deswells in cycles (Histamine?). Experiencing hives that come and go. Some foods like onions make matters worse. My voice becomes hoarse and then it goes normal then goes worse again (I experienced better vocal range and sustainability with the stack but it has lately dropped off in this regard)
have had this pre-PSSD and I believe PSSD just came and used an existing backdoor to make itself prominent.
I want the cure.
Appleman
Posts: 1
Joined: Fri Dec 03, 2021 5:12 am

Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Appleman »

I've been taking this stack for 3 weeks now. I notice some differences...
- increased libido
- my erections have returned (random & on demand)
- orgasm is back to normal.
...but no relief of anhedonia, yet. Some motivation increase.
Jaxx
Posts: 1151
Joined: Sat May 14, 2016 7:55 pm
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Jaxx »

Appleman wrote: Fri Dec 03, 2021 5:15 am I've been taking this stack for 3 weeks now. I notice some differences...
- increased libido
- my erections have returned (random & on demand)
- orgasm is back to normal.
...but no relief of anhedonia, yet. Some motivation increase.
Reporting to your own post on a 2nd account does give the impression this is a scam.
I am closing the topic
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