Final theory of PSSD etiology. Get in here!

This is a place to post research you have done on the topic along with your conclusions.
hplss_wndrr
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Re: Final theory of PSSD etiology. Get in here!

Unread post by hplss_wndrr »

guacamo wrote: Sat Dec 04, 2021 12:24 pm
MisterCharlie wrote: Fri Dec 03, 2021 8:18 pm Im doing Inositol (18 grams)and Phosphatidyl choline (6grams) starting today. Are the dosages and forms alright? I didnt get the jump from phosphatidylcholine to lechitin in what you were saying, im guessing its also a type of choline?

Also want to throw out there that I took Ropinirole (1/2 a pill) and got more penis sensation, more libido, for about a week afterward but I got severe blurry vision/and severe chest pains for a month and a half afterward. Basically I got DMSA to help chelate any residue out of my eyes and took several other things to reduce the side effects. Never taking Ropinirole again but the short term improvement was interesting.

Taking a dopamine antagonist as much as side effects allow, and I now have nightly morning wood almost every night. After no morning wood for at least 4 years. Still have penis sensation problems and unreliable erections tho.

I wonder if a dopamine-serotonin balance could have a part to play. Dopamine antagonists upregulate/sensitize dopamie receptors possibly permanently, so I started with a very very low dose. After a small increase in dosage, over 3 months, got increased ambition amd energy, and a couple weeks later after the last dose, morning wood. Looked into things beforehand and dopamine and testosterone are linked and serotonin (sexual inhibitor) and estrogen are linked.
Lecithin because it contains phospholipids like phosplatidylcholine and phoshpatidylinositol, but taking phosphatidylcholine on itself should be just fine. From what it looks like SJW and inositol works on different mechanisms, inositol simply oversaturates precursors for PIP2 etc, while SJW takes place in IMPase cycle, where different forms of phosphatidyl inositol like PIP2 are metabolised back to myo-inositol for the course to start all over again. As inositol triphoshpate receptor activation on endoplasmic recticulum is part of its cycle. It actually works similar to lithium, which blocks this cycle but in different mechanism, lithium also cured 1 person.
hplss_wndrr wrote: Fri Dec 03, 2021 11:08 pm hi! So, based on this research, which would be the best suggested treatment plan?
There really is no legit treatment based on it's system right now, what is new is that i realized that for PIP2 to be created there needs to be phosphatic acid created by PLD, which needs phosphatidylcholine as its part of the reaction. It is known that inositol on itself cured some people, lecithin on itself cured some people, and in 1 case where inositol cured someone, the person took it alongside high dose choline, about 1,5 gram. I still work around GIRK channel, PIP2, to write this thread i had to read 5-10 papers per day for like 6 months, so i do not know how long will it take to grasp everything related to PIP2. The problem is also that inositol level usually do not raise in cerebellum with supplementation, cerebellum part of is midbrain where raphe nuclei pre synaptic 5-HT1A receptors are, it's the part of the brain we want to target, but it's elusive. I read papers every day but my limitation is obviously time, but i will keep working.
Based on this - would you advise to take them together or one per time?
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guacamo
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Re: Final theory of PSSD etiology. Get in here!

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They work sinergistically so they complement each other, you take inositol to create PIP2, and PIP2 is created via PI5K enzyme, whcich needs phosphatidic acid, which to be created via phospholipase D, it needs phosphatidylcholine. Just remember to observe your body reaction and start slowly. If you react to sjw better you can go sjw, soy lecithin/phoshpatidylcholine.
Last edited by guacamo on Mon Dec 06, 2021 7:24 am, edited 2 times in total.
hplss_wndrr
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Re: Final theory of PSSD etiology. Get in here!

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guacamo wrote: Sat Dec 04, 2021 2:02 pm They work sinergistically so they complement each other. Just remember to observe your body reaction and start slowly. If you react to sjw better you can go sjw, soy lecithin/phoshpatidylcholine and u can add low dose lithium orotate.
Couldn't SJW cause pssd iteself, acting as an ssri? just asking, i'm not an expert in the area unfortunately
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guacamo
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Re: Final theory of PSSD etiology. Get in here!

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SJW is not SSRI, it has affinity to a lot of receptors, more than 40. It does not inhibit serotonin transporter like SSRI, why it reuptakes serotonin is a matter of a debate, some articles say its due to increase of intracellular sodium, but it is debatable. It does not feel like SSRI at all.
Here you have SJW affinity chart to over 40 receptors https://imgur.com/a/HOMGSjW. For me sjw is the best supplement against SSRI induced anhedonia, but reaction differs.
hplss_wndrr
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Re: Final theory of PSSD etiology. Get in here!

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guacamo wrote: Sat Dec 04, 2021 2:08 pm SJW is not SSRI, it has affinity to a lot of receptors, more than 40. It does not inhibit serotonin transporter like SSRI, why it reuptakes serotonin is a matter of a debate, some articles say its due to increase of intracellular sodium, but it is debatable. It does not feel like SSRI at all.
Here you have SJW affinity chart to over 40 receptors https://imgur.com/a/HOMGSjW. For me sjw is the best supplement against SSRI induced anhedonia, but reaction differs.
Thank you, if I can ask you a final thing: do you think there is something to do specifical for ED-only PSSD?
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guacamo
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Re: Final theory of PSSD etiology. Get in here!

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I guess sildenafil works, but if you have no libido i think there is nothing that can be done.
hplss_wndrr
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Re: Final theory of PSSD etiology. Get in here!

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guacamo wrote: Sat Dec 04, 2021 2:45 pm I guess sildenafil works, but if you have no libido i think there is nothing that can be done.
I have libido and erections, though much weaker and less lasting than before. I'd love to go back to my previous erections permanently (as sidenafil would only work at use).

By your readings, does the fact that some progress has happened (from 0% erections to 40-50%) usually mean that total recovery is probable?
MisterCharlie
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Re: Final theory of PSSD etiology. Get in here!

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finities infinities wrote: Sat Dec 04, 2021 10:03 am MisterCharlie- I tryed dopamine antagonist-sulpiride for D2 upregulation. This drug was very weird because tolerance not develop and my state suddenly slighty better only after discontinuation.
The one Im on, blocks d1, d2, and d3 but is weak on D4. Seroquel. I would never try to take stuff like this everyday or even more than 2 times a week.
MisterCharlie
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Re: Final theory of PSSD etiology. Get in here!

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finities infinities wrote: Sat Dec 04, 2021 1:43 pm Reboxetine is GIRK antagonist.
So the theory is a GIRK antagonist will cause upregulation over the long term? And thereby stop internalization of the HT receptor?
finities infinities
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Re: Final theory of PSSD etiology. Get in here!

Unread post by finities infinities »

Maybe. I trying reboxetine for this GIRK resensitization. Seroquel is potent 5ht1a agonist, and desensitize this receptors, bad for PSSD. Your erection improvement is probably from alpha 1 antagonist.
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