Progesterone, 17- Oh progesterone, Androstenedione

[Bigmum]

Also Hashim trial with EGCG od interesting...

[Bigmum]

Page created by ex pfs suffer ( CDnuts)
Many useful informations

http://www.totalmaleoptimization.com/li ... -symptoms/

He didn t mentioned there that he used Androhard 3x 6 weeks with ptc

[DoIt]

Interesting theory:

There have been studies posted on this site showing that SSRIs drastically increase allopregnaolone and adiol-g concentrations at the expense of DHP and DHT. (5-ar activity can't compensate for the increased 3a-HSD activity caused by SSRIs). The resulting DHT deficiency has been speculated to trigger PSSD (Post-SSRI Sexual Dysfunction), in a similar manner as 5-ar inhibition may cause PFS. Either way, you end up with cells that are starved of DHT and other 5-ar metabolites. Not good.
Fairly certain Prof. Melcagni's neurosteroid study discovered very low levels of DHP in the cerebrospinal fluid of PFS patients.

http://www.propeciahelp.com/forum/viewt ... 6&p=101957

[DoIt]

Interesting theory:

There have been studies posted on this site showing that SSRIs drastically increase allopregnaolone and adiol-g concentrations at the expense of DHP and DHT. (5-ar activity can't compensate for the increased 3a-HSD activity caused by SSRIs). The resulting DHT deficiency has been speculated to trigger PSSD (Post-SSRI Sexual Dysfunction), in a similar manner as 5-ar inhibition may cause PFS. Either way, you end up with cells that are starved of DHT and other 5-ar metabolites. Not good.
Fairly certain Prof. Melcagni's neurosteroid study discovered very low levels of DHP in the cerebrospinal fluid of PFS patients.

http://www.propeciahelp.com/forum/viewt ... 6&p=101957

[Bigmum]

The most scarry part cd nut protocol seems to be puting balls into cold water : )))

[Ghost]

Suggesting that Progesterone increases in pregnancy could result in 5HT1A AR desensitization:


Klink et al., 2002
Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons. Part II. Regulatory mechanisms


"During pregnancy, the ED50 for the response to LSD was decreased by about 70%, indicating a partial desensitization of 5-HT1A autoreceptors, which is consistent with the 5-HT neurons higher firing activity. The GABAergic tonic inhibition of 5-HT neurons was assessed using the responses to GABA, bicuculline and isoniazid. Together, they indicate a lower GABAergic tonic inhibition in males and P17 as compared to CF, which is in agreement with their greater 5-HT neurons firing rate. Finally, the efficacy of the long feedback loop, involving postsynaptic 5-HT1A receptors, did not seem affected by gender, ovariectomy or pregnancy since the response to systemic 8-OH-DPAT was similar. These results constitute strong evidence of mechanisms by which gender and hormonal fluctuations can modulate the 5-HT neurons function and influence vulnerability to mood disorders."


"It could, thus, suggest that these modifications of the GABAA receptor function, induced by chronic neurosteroid treatments, are present during pregnancy, when levels of progesterone metabolites are high. This would result in a lesser GABAA receptor responsiveness and would explain the lower GABAergic tonic inhibition of 5-HT neurons observed in the present study."

"Many progesterone metabolites are GABAA receptor modulators. Since we observed a direct correlation between 5-HT neuronal activity and circulating levels of P from P11 to 21, the responsiveness of the DRN 5-HT neurons to GABA, as well as their GABAergic tonic inhibition, had to be explored."

"These results (raising Progesterone) suggest a partial functional desensitization of the 5-HT1A autoreceptor during late
pregnancy."

"During pregnancy, the ED50 for the response to LSD was decreased by about 70%, indicating a partial desensitization of 5-HT1A autoreceptors, which is consistent with the 5-HT neurons higher firing activity."

[Sonny]

Very interesting thread. I have very high testosterone, around 1000 ng/dl give or take, which is sometimes considered above normal depending on the lab. My free testosterone was at the low end of normal though. I'll have to read this over more carefully and ask for additional tests when I have my physical in August.

[Juvo]

Got my progesterone test back:

Progesterone adult 0.3 ng/ml standard range 0.0-0.2

[JayR]

Got my progesterone test back:

Progesterone adult 0.3 ng/ml standard range 0.0-0.2

I see Juvo. Could be something there but its only a point higher. Unusual range they are using though,

[lost_soul]

So - is anyone planning on trying some progesterone antagonists?