Metergoline - 5-ht1a antagonist

[Juvo]

Some metergoline I ordered came today, I did a big dose and noticed instant improvements... Deffo worth doing long term of it becomes cheaper

For anyone following lost souls experiments..please do not attempt in the same way.

The safe way is to titrate (slowly increase) up, not mega dosing, which can injure you.

[lost_soul]

I ended up taking metergoline today. No sexual function improvements but my mood was a little better. Took cialis and dht also but very little change, erections were still basically nonexistent. Also took acid and speed and they won't have helped.

[omar90]

I'd really urge you to take it easy lostsoul, you seem to be on quite a self-destructive path at the moment. Taking recreational drugs is going to make you feel worse.

[siebs1122]

.

[siebs1122]

Hey guys, just wanted to give another update. Since taking low dose metergoline from January-Feburary as well as forskolin, then stopping, I have had long-lasting improvements in every aspect of my PSSD.

I noticed that I never really had a proper introduction on this forum explaining my history and symptoms, so I will take this opportunity to give a brief background.

I started SSRIs back in the beginning of 2014 for OCD, when I was 17 years old. I had no history or symptoms of depression or any other mental illness, aside from OCD when I began SSRIs. Even with the OCD, I was always happy and optimistic and if anything, was over-emotional. I initially tried Luvox and Paxil, both which made my OCD worse and caused a lot of side effects, including sexual dysfunction. However, upon discontinuation of both of these medications, my sexual functioning returned to normal and the side effects went away. It wasn't until my third SSRI, lexapro, that I acquired PSSD. I was on this medication for about 2 months then discontinued because it was making my OCD 100x worse as well as causing many side effects, just like Luvox and Paxil did. However, upon discontinuation, my sexual functioning did not return to normal (weak erections, anorgasmia, genital numbness) and I had many other lexapro-induced side effects that persisted long after discontinuation too(dry mouth, increased appetite, insomnia, photosensitivity, emotional anhedonia, general anxiety, worsened OCD, etc.) I lived like this for 3 years until coming across this forum and soon began experimenting with supplements. I tried inositol, magnesium, and NAC- all to no avail. I then tried circumin, which worsened my PSSD. I was beginning to lose hope until I tried forskolin. I didn't feel an effect from it until about 1 week after starting it, when I noticed a tingling sensation in the back of my head one night. It was a distinct tingling sensation that went from the back of my head, down my spine. The next mourning, I noticed I awoke with a strong erection and my anxiety and other symptoms were significantly better. This electrical sensation in the back of my head came and went, and my PSSD increasingly improved. I soon added metergoline to the forskolin and micro dosed on it for the next month. Over the course of that month, my PSSD and related symptoms virtually disappeared. My sexual functioning is close to pre-SSRI levels and my emotional capacity is well over 80% back. The other side effects that I had from lexapro, like dry mouth and general anxiety are now all gone as well. I feel pretty much how I used to pre-lexapro, albeit certain aspects like motivation are still low.

Although I know many people on here have experimented with forksolin and metergoline, I think more people should, especially the ones who have PSSD from lexapro (which is quite a few). I am sorry for the long post but I hope my partial-success story from metergoline shows that their is hope for this condition and it's not permanent. I am a firm believer that the problem purely lies in simply finding a way to efficiently antagonize 5h2a/2c and up regulate dopamine receptors.

[Miguel29]

That's awesome news siebs! I read on the Area1255 forum that you were also taking Ibudilast. Did that help you at all?

I'm a bit worried about taking a 5htc antagonist as that is one of the mechanisms of action of Fluoxitine. Which was the SSRI that started all of this off PSSD for me. But it's interesting to read that it has helped you. I might need to reconsider. I know Agomelatine also has 5htc antagonism.

I've taken Forskolin quite recently too, following advice on Area1255's forum and do feel like it helps. The effect is for me has been wuite subtle so not at 80% back like yourself but then again I havn't taken Metergoline.

Can I ask where you got it was it Idealabs? and what dosage do you believe was optimal for you?

[Marksanchez397]

Hey guys, just wanted to give another update. Since taking low dose metergoline from January-Feburary as well as forskolin, then stopping, I have had long-lasting improvements in every aspect of my PSSD.

I noticed that I never really had a proper introduction on this forum explaining my history and symptoms, so I will take this opportunity to give a brief background.

I started SSRIs back in the beginning of 2014 for OCD, when I was 17 years old. I had no history or symptoms of depression or any other mental illness, aside from OCD when I began SSRIs. Even with the OCD, I was always happy and optimistic and if anything, was over-emotional. I initially tried Luvox and Paxil, both which made my OCD worse and caused a lot of side effects, including sexual dysfunction. However, upon discontinuation of both of these medications, my sexual functioning returned to normal and the side effects went away. It wasn't until my third SSRI, lexapro, that I acquired PSSD. I was on this medication for about 2 months then discontinued because it was making my OCD 100x worse as well as causing many side effects, just like Luvox and Paxil did. However, upon discontinuation, my sexual functioning did not return to normal (weak erections, anorgasmia, genital numbness) and I had many other lexapro-induced side effects that persisted long after discontinuation too(dry mouth, increased appetite, insomnia, photosensitivity, emotional anhedonia, general anxiety, worsened OCD, etc.) I lived like this for 3 years until coming across this forum and soon began experimenting with supplements. I tried inositol, magnesium, and NAC- all to no avail. I then tried circumin, which worsened my PSSD. I was beginning to lose hope until I tried forskolin. I didn't feel an effect from it until about 1 week after starting it, when I noticed a tingling sensation in the back of my head one night. It was a distinct tingling sensation that went from the back of my head, down my spine. The next mourning, I noticed I awoke with a strong erection and my anxiety and other symptoms were significantly better. This electrical sensation in the back of my head came and went, and my PSSD increasingly improved. I soon added metergoline to the forskolin and micro dosed on it for the next month. Over the course of that month, my PSSD and related symptoms virtually disappeared. My sexual functioning is close to pre-SSRI levels and my emotional capacity is well over 80% back. The other side effects that I had from lexapro, like dry mouth and general anxiety are now all gone as well. I feel pretty much how I used to pre-lexapro, albeit certain aspects like motivation are still low.

Although I know many people on here have experimented with forksolin and metergoline, I think more people should, especially the ones who have PSSD from lexapro (which is quite a few). I am sorry for the long post but I hope my partial-success story from metergoline shows that their is hope for this condition and it's not permanent. I am a firm believer that the problem purely lies in simply finding a way to efficiently antagonize 5h2a/2c and up regulate dopamine receptors.

Are you taking anything yet? Do you think the most important thing for your improvements was forskolin or metergoline?

[siebs1122]

That's awesome news siebs! I read on the Area1255 forum that you were also taking Ibudilast. Did that help you at all?

I'm a bit worried about taking a 5htc antagonist as that is one of the mechanisms of action of Fluoxitine. Which was the SSRI that started all of this off PSSD for me. But it's interesting to read that it has helped you. I might need to reconsider. I know Agomelatine also has 5htc antagonism.

I've taken Forskolin quite recently too, following advice on Area1255's forum and do feel like it helps. The effect is for me has been wuite subtle so not at 80% back like yourself but then again I havn't taken Metergoline.

Can I ask where you got it was it Idealabs? and what dosage do you believe was optimal for you?

Hey Miguel,
So there is a bit of information I left out in my previous post because I didn't want to make the post too long. Forskolin helped me while I was on it, then I ran out of it for a couple days because my order got backed up and I went through a pretty severe withdrawal. When I reinstated forskolin, it no longer helped. After this happened, I was contemplating on going on ibudilast, however, I changed my mind after the metergoline started working.

Yeah, I ordered mine of idealabs and used 1 drop for about a month. I think I was very sensitive to it though, which may be why it worked for me and not for so many others who have tried it. Even at this low dosage, I still had pretty severe side effects (muscle twitches, paranoia). However, it basically returned my sexual functioning and emotions within a few weeks of taking it.

I definitely wouldn't go back on an SSRI either, but certain drugs like metergoline or mianserin might be able to help, with little risk of worsening PSSD. Idealabs seems to be a pretty reliable source for metergoline so I would definitely recommend trying it out!

[siebs1122]

Hey guys, just wanted to give another update. Since taking low dose metergoline from January-Feburary as well as forskolin, then stopping, I have had long-lasting improvements in every aspect of my PSSD.

I noticed that I never really had a proper introduction on this forum explaining my history and symptoms, so I will take this opportunity to give a brief background.

I started SSRIs back in the beginning of 2014 for OCD, when I was 17 years old. I had no history or symptoms of depression or any other mental illness, aside from OCD when I began SSRIs. Even with the OCD, I was always happy and optimistic and if anything, was over-emotional. I initially tried Luvox and Paxil, both which made my OCD worse and caused a lot of side effects, including sexual dysfunction. However, upon discontinuation of both of these medications, my sexual functioning returned to normal and the side effects went away. It wasn't until my third SSRI, lexapro, that I acquired PSSD. I was on this medication for about 2 months then discontinued because it was making my OCD 100x worse as well as causing many side effects, just like Luvox and Paxil did. However, upon discontinuation, my sexual functioning did not return to normal (weak erections, anorgasmia, genital numbness) and I had many other lexapro-induced side effects that persisted long after discontinuation too(dry mouth, increased appetite, insomnia, photosensitivity, emotional anhedonia, general anxiety, worsened OCD, etc.) I lived like this for 3 years until coming across this forum and soon began experimenting with supplements. I tried inositol, magnesium, and NAC- all to no avail. I then tried circumin, which worsened my PSSD. I was beginning to lose hope until I tried forskolin. I didn't feel an effect from it until about 1 week after starting it, when I noticed a tingling sensation in the back of my head one night. It was a distinct tingling sensation that went from the back of my head, down my spine. The next mourning, I noticed I awoke with a strong erection and my anxiety and other symptoms were significantly better. This electrical sensation in the back of my head came and went, and my PSSD increasingly improved. I soon added metergoline to the forskolin and micro dosed on it for the next month. Over the course of that month, my PSSD and related symptoms virtually disappeared. My sexual functioning is close to pre-SSRI levels and my emotional capacity is well over 80% back. The other side effects that I had from lexapro, like dry mouth and general anxiety are now all gone as well. I feel pretty much how I used to pre-lexapro, albeit certain aspects like motivation are still low.

Although I know many people on here have experimented with forksolin and metergoline, I think more people should, especially the ones who have PSSD from lexapro (which is quite a few). I am sorry for the long post but I hope my partial-success story from metergoline shows that their is hope for this condition and it's not permanent. I am a firm believer that the problem purely lies in simply finding a way to efficiently antagonize 5h2a/2c and up regulate dopamine receptors.

Are you taking anything yet? Do you think the most important thing for your improvements was forskolin or metergoline?

Currently not taking anything, and definitely metergoline.

[Numbed]

Hey guys, just wanted to give another update. Since taking low dose metergoline from January-Feburary as well as forskolin, then stopping, I have had long-lasting improvements in every aspect of my PSSD.

I noticed that I never really had a proper introduction on this forum explaining my history and symptoms, so I will take this opportunity to give a brief background.

I started SSRIs back in the beginning of 2014 for OCD, when I was 17 years old. I had no history or symptoms of depression or any other mental illness, aside from OCD when I began SSRIs. Even with the OCD, I was always happy and optimistic and if anything, was over-emotional. I initially tried Luvox and Paxil, both which made my OCD worse and caused a lot of side effects, including sexual dysfunction. However, upon discontinuation of both of these medications, my sexual functioning returned to normal and the side effects went away. It wasn't until my third SSRI, lexapro, that I acquired PSSD. I was on this medication for about 2 months then discontinued because it was making my OCD 100x worse as well as causing many side effects, just like Luvox and Paxil did. However, upon discontinuation, my sexual functioning did not return to normal (weak erections, anorgasmia, genital numbness) and I had many other lexapro-induced side effects that persisted long after discontinuation too(dry mouth, increased appetite, insomnia, photosensitivity, emotional anhedonia, general anxiety, worsened OCD, etc.) I lived like this for 3 years until coming across this forum and soon began experimenting with supplements. I tried inositol, magnesium, and NAC- all to no avail. I then tried circumin, which worsened my PSSD. I was beginning to lose hope until I tried forskolin. I didn't feel an effect from it until about 1 week after starting it, when I noticed a tingling sensation in the back of my head one night. It was a distinct tingling sensation that went from the back of my head, down my spine. The next mourning, I noticed I awoke with a strong erection and my anxiety and other symptoms were significantly better. This electrical sensation in the back of my head came and went, and my PSSD increasingly improved. I soon added metergoline to the forskolin and micro dosed on it for the next month. Over the course of that month, my PSSD and related symptoms virtually disappeared. My sexual functioning is close to pre-SSRI levels and my emotional capacity is well over 80% back. The other side effects that I had from lexapro, like dry mouth and general anxiety are now all gone as well. I feel pretty much how I used to pre-lexapro, albeit certain aspects like motivation are still low.

Although I know many people on here have experimented with forksolin and metergoline, I think more people should, especially the ones who have PSSD from lexapro (which is quite a few). I am sorry for the long post but I hope my partial-success story from metergoline shows that their is hope for this condition and it's not permanent. I am a firm believer that the problem purely lies in simply finding a way to efficiently antagonize 5h2a/2c and up regulate dopamine receptors.

Siebs..... not trying to spoil your fun here, but metergoline actually upregulates 5ht1a (not sure if autoreceptor or not) and 5ht2a after a few days.
I used to be active on raypeatforum aswell thats where i got my metergoline aswell, i left that forum though its full of blind fools who believe everything that raypeat says.

Like you i responded strong to it, only used it once and was scared by its effectiveness, the effect lasted the entire day, i felt more masculin on it, more direct, but also morw arrogant and i actually felt less attracted to people.
Few days after i felt VERY good and had libido that day, im pretty sure thats where the met worn off and my 5ht2a receptors temporarily got upregulated above my "normal" pssd baseline.

Also 5ht2a antagonism isnt fun at all, its very emotionally dulling.
I will deffo try met in the future, heck my bottle is still basically full.