"Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine"

[fakeaccount]

https://www.mdpi.com/2077-0383/8/2/133/
https://www.mdpi.com/2077-0383/8/2/133/pdf

[Snake]

Doesn't sound good.

[Blueturtle]

This looks like good research, thank you for sharing this.

Yup. Even more data implicating dopamine in PSSD, so many of the symptoms of PSSD seem to implicate dopamine, such as the emotional blunting some have reported. Also explains why some folks here (including myself) have gotten at least temporarily better with dopamine medications.

[anacleta]

Who contacts the authors of this research, asking them about the PSSD?


To try to connect this tyrosine to the neurosteroid theory, you can search with keywords: tyrosine allopregnanolone, tyrosine estrogens. Is the amino acid tyrosine the cause or consequence, if any, of altered neurosteroids? (however we still await the results of the Melcangi study)

Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors alpha and beta and interactions with cyclic AMP.
https://www.ncbi.nlm.nih.gov/pubmed/15935066

..

[Snake]

Who contacts the authors of this research, asking them about the PSSD?


To try to connect this tyrosine to the neurosteroid theory, you can search with keywords: tyrosine allopregnanolone, tyrosine estrogens. Is the amino acid tyrosine the cause or consequence, if any, of altered neurosteroids? (however we still await the results of the Melcangi study)

Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors alpha and beta and interactions with cyclic AMP.
https://www.ncbi.nlm.nih.gov/pubmed/15935066

..

Someone should contact them for sure. @Ghost, are you there?

[Marksanchez397]

https://www.mcgill.ca/newsroom/channels ... ons-266833

[Meso]

N-acetylcysteine (NAC) upregulates tyrosine hydroxylase by 300%
https://www.ncbi.nlm.nih.gov/pubmed/11742214

And Panax Ginseng downregulates it.

[iull1k]

Do you remember that a lot of us had high Progesterone?


The progesterone (P(4)) rise on proestrous afternoon is associated with dephosphorylation of tyrosine hydroxylase (TH) and reduced TH activity in the stalk-median eminence (SME), which contributes to the proestrous prolactin surge in rats.

Progesterone Induces Dephosphorylation and Inactivation of Tyrosine Hydroxylase in Rat Hypothalamic Dopaminergic Neurons

[TalkingAnt]

It's a good article. It cites some good previous studies as well. I recommend it if you can understand the neurobiology.

If tyrosine hydroxylase is inhibited in PSSD, perhaps exogenous dopamine can be of help, such as L-DOPA/mucuca puriens.

Here is an article with some ideas to raise TH:
https://mybiohack.com/blog/increase-tyr ... e-dopamine

Chronic morphine use may upregulate TH in the VTA region of the brain, which is important for sex:
https://pdfs.semanticscholar.org/f383/2 ... 986b3e.pdf
However, sexual dysfunction is a common side effect of opiod use, so this is not the full picture.

Anyway, I think looking into dopamine pathways is a good lead.

[sovietxrobot]

It's a good article. It cites some good previous studies as well. I recommend it if you can understand the neurobiology.

If tyrosine hydroxylase is inhibited in PSSD, perhaps exogenous dopamine can be of help, such as L-DOPA/mucuca puriens.

I have had a lot of success with mucuna pruriens.