Introduction - seeking help from Mesolimbo

[WeWillOvercome]

Hi Mesolimbo,

I see how you have advised others on this forum and I am hoping that you can do the same for me. I don't think I need to tell you just how desperate this situation is, so I would appreciate your input. Let me know if you need any more info from me.

1- What is your gender?

Male

2- Why did you take antidepressants in the first place? and for how long were you on them? which med?

Fluoxetine 20 MG for 3-4 months for pervasive anxiety and depression. A general feeling of self loathing and regretting/agonizing over past decisions.

3- How was your sexual and emotional function before antidepressant intake?

Sexual – my sexual function was very strong – I will say that from ages 15-20 (early period of being sexually active), I experienced performance anxiety. At the same time I had PE, I could masturbate with no issues and would be aroused by pornography/had morning erections, etc. After SSRI’s, it became extremely difficult (if not impossible) to maintain an erection during intercourse or masturbation.

Emotionally I had a large spectrum, from being very happy to profoundly depressed. The depression was more common than happiness.

4- What are your symptoms exactly and when did they start? sexual dyfunction alone, or cognitive/emotional/hedonistic as well? which symptom is bothering you the most?

Zero libido
Profound erectile dysfunction
Loss of morning erections
Anhedonia
Emotional blunting
I began to experience all of these symptoms the day after I took my first dose of Fluoxetine

5- What meds/supplements have you tried so far?

L – Arginine
Horny Goat Weed
Maca
CDP Choline
Wellbutrin
Addyi
Ella
Pramipexole
Buspirone
Bethanechol
Inositol
Sertraline low dose
Low dose psilocybin
Cannabis
Low dose naltrexone
SJW

6- Do you have access to meds without prescription (buy online), or would strictly require a prescription for meds to try?

I can get a prescription for most meds within reason, thanks to a receptive psychiatrist that I am working with.

7- Can you tolerate galicky foods? what about proteins?

Yes

8- Have you done any blood testing? what were the results?

Yes, I have had several full blood panels done over the past three years. One indicated that I had slightly low testosterone, but that was done in the afternoon and the doctor recommended that I repeat the test in the morning (when T levels are generally higher). The following morning’s test reflected T in the normal range. About a year later, I had another blood panel done and my prolactin was slightly low. Outside of that, all other blood panels have reflected normal ranges.

[Meso]

Did you get any window of relief in the past? How did you react to psilocybin and LDN?

[WeWillOvercome]

Thanks for the response. I have had no windows of improvement or recovery. The only thing that has helped me is PDE5 inhibitors, but that of course does not affect libido/desire.

LDN did nothing for me. I took it for about 5 weeks.

[naiverat]

Thanks for the response. I have had no windows of improvement or recovery. The only thing that has helped me is PDE5 inhibitors, but that of course does not affect libido/desire.

LDN did nothing for me. I took it for about 5 weeks.

What dose of LDN were you on? I've had good results on higher doses than the typical 5mg >. With that said, it can increase anxiety and anhedonia a bit initially, but tends to even out fairly quickly. Have you run any labs?