Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

This is for hypothesis and even educated speculation.
CN9
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Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by CN9 »

Area1255_2021 wrote: Fri Aug 20, 2021 4:35 pm
CN9 wrote: Mon Aug 16, 2021 2:01 pm
Area1255_2021 wrote: Sun Aug 15, 2021 4:54 pm
The root cause of PSSD could be nNOS-nitric oxide dysfunction; it cuts off the signals to the hypothalamus, dampens/weakens/makes insignificant those networks - decreases Androgen sensitivity and cuts off normal function of Dopamine. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333763/) You need to get your salt levels up, take 1 teaspoon of Salt/Sodium per day; https://pubmed.ncbi.nlm.nih.gov/7510737/

...as far as Erections; add Pomegranate Juice to the Cialis. Drink Pomegranate juice (non-concentrate) 3-4 8 oz cups per day: https://pubmed.ncbi.nlm.nih.gov/27785815/
...It restores nNOS.
Also - Histamine is central in nNOS - it stimulates cAMP which regulates nNOS; PSSD is VERY STRONGLY a LOW histamine disorder...
...but you have to correct the deficit in nNOS proteins & nitric oxide signaling along with it or Histamine won't fire in the "right/correct" areas of the Brain/Penis.
Thanks, I will take that extra spoon of salt, but I'm irritated. I must already eat a lot salt, because of my fast food nutrition and if not fast food, it s the turkish kitchen, which Loves salt.
but let s see...

Won t take cialis at the moment, I get heartburn of it. Can't take it anymore. When I start eating healthy, I will try that combo.

I was suspecting low histamine too, because my house dust allergy isn t as present as before PSSD.
But If I take L Histidin, or SJW, my joint inflammations hurt too much. I have an ossification on my olecranon (bursitis?), what also got much worse after sertraline (4 weeks summer 2017). it was okay for years under escitalopram (2012 - 2016)... also other areas like both shoulders, knees, back/spine made Problems. it all happened in the gym on sertraline (very weak muscles too). It fucked up something really really bad.
I'm sure, if I didn t have taken sertraline, the erectile dysfunction and mild anhedonia I could have handled with the common stuff (inositol, l arginin, Forskolin, berberine, omega....) because I did to a acceptable degree but this feeling tightness, lack of being tired in a healthy way (being Able to sleep fast and or long), this lack of being able to daydream, fall in love, lack of feel time passing slow to relax and enjoy, that buzz from Alcohol, all this is due to setraline (and or paroxetine, which I Took 10 days long before setraline... but most of the remaining Symptoms I got from S. But who knows, perhaps it was the combination, that cold turkey of Paroxetine with Sertraline directly after...however)

I always thought, that an escitalopram induced PSSD can't be as complex and multifaceted as a PSSD induced by Sertraline or Paroxetine because they target much more Transmitters in a significant way. Setralines Dopaminergic effects were very present for me... or was it the sigma-receptor, which made me very talkactive and clear in my mind?! or a 5-ht receptor in a Different area of my brain, where escitaloprames SERT inhibition was too weak!?
Who also gets crazy about those questions????
Yes its tricky because with SSRI's you might have high histamine in the blood or generally in the body but low in the Brain where it needs to be - always a possibilty...but you could have inflammation from other pathways - as well. Have you tried Turmeric/Curcumin extract for inflammation?
--> https://nootropicsdepot.com/curowhite-c ... t-tablets/
^ That one works REAL well! ;)
I used a bottle back in 2018. Can't remember the effects. I'll try it again. thanks for the tip.
Jaxx
Posts: 1151
Joined: Sat May 14, 2016 7:55 pm
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Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by Jaxx »

Area1255_2021 wrote: Fri Aug 20, 2021 4:35 pm
CN9 wrote: Mon Aug 16, 2021 2:01 pm
Area1255_2021 wrote: Sun Aug 15, 2021 4:54 pm
The root cause of PSSD could be nNOS-nitric oxide dysfunction; it cuts off the signals to the hypothalamus, dampens/weakens/makes insignificant those networks - decreases Androgen sensitivity and cuts off normal function of Dopamine. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333763/) You need to get your salt levels up, take 1 teaspoon of Salt/Sodium per day; https://pubmed.ncbi.nlm.nih.gov/7510737/

...as far as Erections; add Pomegranate Juice to the Cialis. Drink Pomegranate juice (non-concentrate) 3-4 8 oz cups per day: https://pubmed.ncbi.nlm.nih.gov/27785815/
...It restores nNOS.
Also - Histamine is central in nNOS - it stimulates cAMP which regulates nNOS; PSSD is VERY STRONGLY a LOW histamine disorder...
...but you have to correct the deficit in nNOS proteins & nitric oxide signaling along with it or Histamine won't fire in the "right/correct" areas of the Brain/Penis.
Thanks, I will take that extra spoon of salt, but I'm irritated. I must already eat a lot salt, because of my fast food nutrition and if not fast food, it s the turkish kitchen, which Loves salt.
but let s see...

Won t take cialis at the moment, I get heartburn of it. Can't take it anymore. When I start eating healthy, I will try that combo.

I was suspecting low histamine too, because my house dust allergy isn t as present as before PSSD.
But If I take L Histidin, or SJW, my joint inflammations hurt too much. I have an ossification on my olecranon (bursitis?), what also got much worse after sertraline (4 weeks summer 2017). it was okay for years under escitalopram (2012 - 2016)... also other areas like both shoulders, knees, back/spine made Problems. it all happened in the gym on sertraline (very weak muscles too). It fucked up something really really bad.
I'm sure, if I didn t have taken sertraline, the erectile dysfunction and mild anhedonia I could have handled with the common stuff (inositol, l arginin, Forskolin, berberine, omega....) because I did to a acceptable degree but this feeling tightness, lack of being tired in a healthy way (being Able to sleep fast and or long), this lack of being able to daydream, fall in love, lack of feel time passing slow to relax and enjoy, that buzz from Alcohol, all this is due to setraline (and or paroxetine, which I Took 10 days long before setraline... but most of the remaining Symptoms I got from S. But who knows, perhaps it was the combination, that cold turkey of Paroxetine with Sertraline directly after...however)

I always thought, that an escitalopram induced PSSD can't be as complex and multifaceted as a PSSD induced by Sertraline or Paroxetine because they target much more Transmitters in a significant way. Setralines Dopaminergic effects were very present for me... or was it the sigma-receptor, which made me very talkactive and clear in my mind?! or a 5-ht receptor in a Different area of my brain, where escitaloprames SERT inhibition was too weak!?
Who also gets crazy about those questions????
Yes its tricky because with SSRI's you might have high histamine in the blood or generally in the body but low in the Brain where it needs to be - always a possibilty...but you could have inflammation from other pathways - as well. Have you tried Turmeric/Curcumin extract for inflammation?
--> https://nootropicsdepot.com/curowhite-c ... t-tablets/
^ That one works REAL well! ;)
Area, in one of your earlier posts you mentioned you got cured on histidine, berberine and icariin. (mrstaircase actually did too, but many others didnt see benefits). Do you no longer believe in this theory?
Area1255_2021
Posts: 168
Joined: Sun Aug 15, 2021 4:45 pm

Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by Area1255_2021 »

I still believe in this theory --> Nitric Oxide Stack to Treat PSSD Naturally 2021 (Cure PSSD Naturally 2021)
Also,... Nitric Oxide upregulates Androgen Receptors (AR).
Jaxx wrote: Wed Aug 25, 2021 6:55 am
Area1255_2021 wrote: Fri Aug 20, 2021 4:35 pm
CN9 wrote: Mon Aug 16, 2021 2:01 pm

Thanks, I will take that extra spoon of salt, but I'm irritated. I must already eat a lot salt, because of my fast food nutrition and if not fast food, it s the turkish kitchen, which Loves salt.
but let s see...

Won t take cialis at the moment, I get heartburn of it. Can't take it anymore. When I start eating healthy, I will try that combo.

I was suspecting low histamine too, because my house dust allergy isn t as present as before PSSD.
But If I take L Histidin, or SJW, my joint inflammations hurt too much. I have an ossification on my olecranon (bursitis?), what also got much worse after sertraline (4 weeks summer 2017). it was okay for years under escitalopram (2012 - 2016)... also other areas like both shoulders, knees, back/spine made Problems. it all happened in the gym on sertraline (very weak muscles too). It fucked up something really really bad.
I'm sure, if I didn t have taken sertraline, the erectile dysfunction and mild anhedonia I could have handled with the common stuff (inositol, l arginin, Forskolin, berberine, omega....) because I did to a acceptable degree but this feeling tightness, lack of being tired in a healthy way (being Able to sleep fast and or long), this lack of being able to daydream, fall in love, lack of feel time passing slow to relax and enjoy, that buzz from Alcohol, all this is due to setraline (and or paroxetine, which I Took 10 days long before setraline... but most of the remaining Symptoms I got from S. But who knows, perhaps it was the combination, that cold turkey of Paroxetine with Sertraline directly after...however)

I always thought, that an escitalopram induced PSSD can't be as complex and multifaceted as a PSSD induced by Sertraline or Paroxetine because they target much more Transmitters in a significant way. Setralines Dopaminergic effects were very present for me... or was it the sigma-receptor, which made me very talkactive and clear in my mind?! or a 5-ht receptor in a Different area of my brain, where escitaloprames SERT inhibition was too weak!?
Who also gets crazy about those questions????
Yes its tricky because with SSRI's you might have high histamine in the blood or generally in the body but low in the Brain where it needs to be - always a possibilty...but you could have inflammation from other pathways - as well. Have you tried Turmeric/Curcumin extract for inflammation?
--> https://nootropicsdepot.com/curowhite-c ... t-tablets/
^ That one works REAL well! ;)
Area, in one of your earlier posts you mentioned you got cured on histidine, berberine and icariin. (mrstaircase actually did too, but many others didnt see benefits). Do you no longer believe in this theory?
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