Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

This is a place to post research you have done on the topic along with your conclusions.
Area1255_2021
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Area1255_2021 »

Thank You for that MindChanger...
MindChanger
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by MindChanger »

Everyone really interested, read those studies. I'd recommend to read fully the first study: especially serotonin and anxiety parts. Link with ERK phosphorylation and CREB activity as well as 5HT1A and SERT connection looks really important here.

1. Neuronal nitric oxide synthase and affective disorders (https://www.sciencedirect.com/science/a ... 0117300493).
2. Role of ERK signaling in activity-dependent modifications of histone proteins (https://www.sciencedirect.com/science/a ... 081400046X).
3. ROS and ERK signaling facilitate epigenetic silencing and support the fact that subtle increase of ROS above basal level act as key cell signaling molecules (https://pubmed.ncbi.nlm.nih.gov/30954555/).
4. cAMP/PKA Agonist Restores the Fasting-Induced Down-Regulation of nNOS Expression in the Paraventricular Nucleus *https://synapse.koreamed.org/articles/1025822)
5. Both dexamethasone and cycloheximide, which completely inhibited the induction of the calcium-independent NOS activity, caused a 40-70% recovery in calcium-dependent NOS activity when compared with slices collected immediately after OGD (https://pubmed.ncbi.nlm.nih.gov/9886076/).
6. Decrease in surface expression of GLuN2B-containing NMDA receptor after reducing endogenous nNOS expression is responsible for reduced glutamatergic synaptic transmission, which may be involved in behavioral aberrations associated with ASD (https://www.frontiersin.org/articles/10 ... 00886/full).
MisterCharlie
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by MisterCharlie »

Area1255_2021 wrote: Mon Nov 08, 2021 9:26 pm Thank You for that MindChanger...
Any thought about a replacement for cialis? Ill do my own search as well.
MisterCharlie
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by MisterCharlie »

I dont have nearly as severe pssd as others on here, just fyi.

So I was having one or two orgasms a day, after 2 weeks on the nitric cycle but no cialis (too much side effects) but not that much improvement in genital sensation, and not feeling too good in terms of my health, nervous all the time, and definitely blurry vision the day of taking histidine. Ive been taking different vitamins to correct the bad feeling, vitamin C,D,E, phosphatidyl choline, and nothing worked until I took 4 pills of zinc (with fat so not to get nauseous) and 80% of my improvement went away for two days so far. My penis still looks bigger than post pssd tho. I looked up zinc deficiency and it causes Serotonin and Gaba to drop (sexual inhibitors). If large amounts of histidine causes a zinc deficiency then that would explain what I'm feeling and why the improvements stopped so drastically after zinc supplementation.

Ropinirole increased my libido and genital sensation for a week but is quite possibly the most toxic drug Ive ever taken. Bad heart and eye pain for 3 weeks afterward after a single 1/2 of a pill.

Waiting for my eyes to improve then might try Seroquel (also linked to eye problems) to antagonize the dopamine receptors and cause them to upregulate in the long term.
MisterCharlie
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by MisterCharlie »

"Stimulation of NMDARs results in activation of neuronal nitric oxide synthase (nNOS), an enzyme catalyzing the formation of nitric oxides (NO) from L-arginine (Garthwaite et al., 1989). NMDARs are predominantly concentrated in the limbic system, a brain area that has close relationship with MDD, BPD and anxiety"

From MinderChangers 1st article, last post on affective disorders.

Something like clozapine, an NMDAR agonist, could increase nNOS?
Jaxx
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Jaxx »

Not sure how many can relate but l-histadine seems to make me more numb (mentally. In fact, although viagra works for me it also makes me a bit numb.
Area1255_2021
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Area1255_2021 »

MisterCharlie wrote: Thu Nov 11, 2021 5:30 am I dont have nearly as severe pssd as others on here, just fyi.

So I was having one or two orgasms a day, after 2 weeks on the nitric cycle but no cialis (too much side effects) but not that much improvement in genital sensation, and not feeling too good in terms of my health, nervous all the time, and definitely blurry vision the day of taking histidine. Ive been taking different vitamins to correct the bad feeling, vitamin C,D,E, phosphatidyl choline, and nothing worked until I took 4 pills of zinc (with fat so not to get nauseous) and 80% of my improvement went away for two days so far. My penis still looks bigger than post pssd tho. I looked up zinc deficiency and it causes Serotonin and Gaba to drop (sexual inhibitors). If large amounts of histidine causes a zinc deficiency then that would explain what I'm feeling and why the improvements stopped so drastically after zinc supplementation.

Ropinirole increased my libido and genital sensation for a week but is quite possibly the most toxic drug Ive ever taken. Bad heart and eye pain for 3 weeks afterward after a single 1/2 of a pill.

Waiting for my eyes to improve then might try Seroquel (also linked to eye problems) to antagonize the dopamine receptors and cause them to upregulate in the long term.
Once again, glad to hear you are getting results!!! Sorry about the side-effects.
Area1255_2021
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Area1255_2021 »

Any updates people???
Jcumbo
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by Jcumbo »

I thought pomegranate juice is an antiandrogen it messes with
Alpha reductase either over expressing or under I can't remember, I'm not technical but what are your thoughts?
ErgogenicHealth
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Re: Nitric Oxide Stack to Treat PSSD (Cure PSSD Protocol 2021)

Unread post by ErgogenicHealth »

Imeniaan wrote: Fri Oct 08, 2021 1:40 am
ErgogenicHealth wrote: Thu Oct 07, 2021 3:26 am I have been adhering to Area1255 suggestions, with Betahistine, and it is now day 9 and something may have flipped the switch. I have been in 4 day window now, don't want to speak to soon, but FU** I am feeling like my young self again. FULL sensation, full body orgasm and libido so strong that staring at hot girls easily gets me hard.
Lucas, what is your EXACT protocol please?

Thank you.
I did Betahistine 16mg twice daily for like 4-5 days. It felt BAD on the drug, but I think it has left my brain in a positive place.
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