Restoring GIRK channels signaling

This is for hypothesis and even educated speculation.
MisterCharlie
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Re: Restoring GIRK channels signaling

Unread post by MisterCharlie »

Meso wrote: Sun Mar 17, 2019 4:45 am One of the most plausible theories I've read is GIRK channel decoupling w/ 5HT1A or downregulation of GIRK channel response. I have no access to agents that can effectively lower central serotonin level (Shilajit, etc), so the next logical step for me is to enhance GIRK response.

Neuropeptide Y (NPY) is an important GIRK activator through NPY1 receptor. It plays an important role in reinforcing drugs of abuse effect, addiction and dependency
How about a NPY1 receptor antagonist (to upregulate)? try that? if so, what did you try?
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