Bone loss caused by PSSD

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pssdperson
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Bone loss caused by PSSD

Unread post by pssdperson »

There's many research out there about SSRIs causing bone loss, for example:

https://pubmed.ncbi.nlm.nih.gov/27595322/,
https://www.bbrfoundation.org/content/b ... y-suggests,
https://www.nih.gov/news-events/nih-res ... epressants.

I know of some people with long term PSSD who have reported severe bone loss diagnosis, as well as some changes such as decrease in jaw size. I myself really suspect I also have bone loss because of PSSD and my jaw for example is getting smaller. I've also seen PFS people report this.

And I was wondering if anyone has any ideas about how to reverse or prevent further bone loss while living with PSSD state?
Henrik
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Re: Bone loss caused by PSSD

Unread post by Henrik »

Drinking milk will prevent bone loss i think ;)
Brain food
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Re: Bone loss caused by PSSD

Unread post by Brain food »

pssdperson wrote: Mon Apr 11, 2022 3:58 pm There's many research out there about SSRIs causing bone loss, for example:

https://pubmed.ncbi.nlm.nih.gov/27595322/,
https://www.bbrfoundation.org/content/b ... y-suggests,
https://www.nih.gov/news-events/nih-res ... epressants.

I know of some people with long term PSSD who have reported severe bone loss diagnosis, as well as some changes such as decrease in jaw size. I myself really suspect I also have bone loss because of PSSD and my jaw for example is getting smaller. I've also seen PFS people report this.

And I was wondering if anyone has any ideas about how to reverse or prevent further bone loss while living with PSSD state?
Testosterone replacement therapy might be a solution. Low testosterone can cause osteoporosis.
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TalkingAnt
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Re: Bone loss caused by PSSD

Unread post by TalkingAnt »

You can protect your bones and connective tissue by making them stronger. You can stimulate the tissues to regenerate with weight-bearing exercise. Bone and connective tissue build more slowly than muscle but with patience you can significantly strengthen them.

You can also support bone remodeling and collagen synthesis with nutrition.

Testosterone and IGF-1 should be in healthy ranges. Exercise also releases test and growth hormone. There are various "hacks" like HIIT or bloodflow restriction to increase post-exercise hormone release.
Cured | PSSD 2012-2020 | Log thread
GIXXER
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Re: Bone loss caused by PSSD

Unread post by GIXXER »

I don't see how PSSD causes bone loss. A quick look at the links you provided suggested SSRI's caused the bone density loss. Seems like these drugs come with a long list of harsh seprate side effects. To say PSSD is causing bone density loss only makes it more confusing to others, and muddies the waters.
pssdperson
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Re: Bone loss caused by PSSD

Unread post by pssdperson »

GIXXER wrote: Mon Apr 11, 2022 10:40 pm I don't see how PSSD causes bone loss. A quick look at the links you provided suggested SSRI's caused the bone density loss. Seems like these drugs come with a long list of harsh seprate side effects. To say PSSD is causing bone density loss only makes it more confusing to others, and muddies the waters.
I’m not saying everyone gets bone loss, all I’m saying is that there’s research indicating SSRI treatment causes bone loss and since PSSD tend to be a condition in which the biochemical alterations caused by SSRIs don’t resolve and there’s studies indicating that SERT knockout causes bone loss and bone abnormalities in mice, I can see how living in this chronic state could *potentially* cause bone loss. I know people with PSSD diagnosed with severe bone loss and I myself have symptoms of reduced bone mass.

References:

​​[Effect of SSRIs on bone metabolism].https://europepmc.org/article/med/23810751
Mice with genetic disruption of 5-HTT (SERT KO) have a bone phenotype of decreased bone mass, altered architecture, and decreased mechanical properties.

https://www.researchgate.net/publicatio ... _Fractures Possible mechanisms include alternations in dopaminergic and/or serotonergic signaling pathways. As these medications distribute to the bone marrow as well as to the brain, it is possible that drug-induced fractures are due to both centrally mediated effects as well as direct effects on bone turnover.


https://www.nature.com/articles/s41398-020-0819-5
Fluoxetine is a commonly prescribed antidepressant, and the mechanisms of increased bone fragility with its long-term use remain largely unknown. Here, we show that long-term administration of fluoxetine induces the disruption of sphingolipids metabolism in bone marrow adipose tissue (BMAT)through the inhibition of acid sphingomyelinase (ASM)."

Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression. - PubMed - NCBI
Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression.
Fernandes BS1,2, Hodge JM3,4, Pasco JA1,5, Berk M1,6, Williams LJ7.
Drugs Aging. 2016 Jan;33(1):21-5. doi: 10.1007/s40266-015-0323-4.
"Selective serotonin reuptake inhibitors (SSRIs), first-line agents in the pharmacological treatment of mood and anxiety disorders, have also been shown to negatively affect bone metabolism."

Evaluation of the effect of selective serotonin reuptake inhibitors on bone mineral density: an observational cross-sectional study. - PubMed - NCBI
"SSRI therapy in GAD was found to be related with decreased BMD values."

Use of selective serotonin reuptake inhibitors and bone mass in adolescents: An NHANES study. - PubMed - NCBI
"In this NHANES study, adolescents treated with SSRIs had lower DXA measurements of the total femur and lumbar spine compared to SSRI non-users."

SSRI use and risk of fractures among perimenopausal women without mental disorders. - PubMed - NCBI
"SSRIs appear to increase fracture risk among middle-aged women without psychiatric disorders, an effect sustained over time, suggesting that shorter duration of treatment may decrease fracture risk."

Use of SSRIs may Impact Bone Density in Adolescent and Young Women with Anorexia Nervosa. - PubMed - NCBI
"Duration of SSRI use, duration since AN[anorexia nervosa] diagnosis and duration of amenorrhea inversely predicted BMD [bone mineral density]"

Antidepressant medications and osteoporosis. - PubMed - NCBI
"...there is a dose-response relationship for SSRIs, the effect does not appear to be homogeneous across the whole class of drugs.... The increase in risk is the greatest in the early stages of treatment, with a dramatic increase after initiation...."

Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men. - PubMed - NCBI
Arch Intern Med. 2007 Jun 25;167(12):1246-51.
Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men.
"BMD [bone mineral density] was lower among those reporting current SSRI use, but not among users of other antidepressants."

Adherence to treatment with selective serotonin reuptake inhibitors and the risk for fractures and bone loss: a population-based cohort study. - PubMed - NCBI
"Exposure to SSRI treatment is associated with an increased risk of bone loss-related events."

Calcaneal bone mineral density in young adults prescribed selective serotonin reuptake inhibitors. - PubMed - NCBI
"...a significant negative correlation was observed between the duration of SSRI use and bone mineral density."

Selective serotonin reuptake inhibitors and the risk of osseointegrated implant failure: a cohort study. - PubMed - NCBI
"...treatment with SSRIs is associated with an increased failure risk of osseointegrated implants, which might suggest a careful surgical treatment planning for SSRI users."

Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression. - PubMed - NCBI
"Selective serotonin reuptake inhibitors (SSRIs), first-line agents in the pharmacological treatment of mood and anxiety disorders, have also been shown to negatively affect bone metabolism. SSRIs are the most prescribed antidepressants worldwide and a large number of persons at risk of developing osteoporosis, including older patients, will receive these antidepressants."

Use of selective serotonin reuptake inhibitors and risk of fracture: a systematic review and meta-analysis. - PubMed - NCBI
"Fracture risk associated with SSRI use may have a significant clinical impact. Clinicians should carefully consider bone mineral density screening before prescribing SSRIs and proper management for high-risk populations."

Selective serotonin reuptake inhibitor treatment and risk of fractures: a meta-analysis of cohort and case-control studies. - PubMed - NCBI
"Use of SSRIs is associated with increased risk of fracture. The SSRIs may exert an increased risk of fracture independent of depression and bone mineral density."

Effect of selective serotonin reuptake inhibitors on the risk of fracture. - PubMed - NCBI
"Daily SSRI use in adults 50 years and older remained associated with a 2-fold increased risk of clinical fragility fracture after adjustment for potential covariates"

Longitudinal examination of the skeletal effects of selective serotonin reuptake inhibitors and risperidone in boys. - PubMed - NCBI
"Chronic SSRI treatment in children and adolescents is associated with reduced, albeit stable, bone mass for age..."

Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. - PubMed - NCBI
"Not only users of TCAs but also of SSRIs have a significantly increased risk of nonvertebral fractures, in SSRI users especially after prolonged use. Despite fewer early adverse effects of SSRIs, physicians treating elderly depressive patients should be aware of the unfavorable long-term consequence of SSRIs on fracture risk."

A cross-sectional evaluation of the effect of risperidone and selective serotonin reuptake inhibitors on bone mineral density in boys. - PubMed - NCBI
"...treatment with selective serotonin reuptake inhibitors (SSRIs) to be associated with lower trabecular BMD at the radius (P = .03) and BMD z score at the lumbar spine (P < .05). These findings became more marked when the analysis was restricted to non-Hispanic white patients."

https://www.ncbi.nlm.nih.gov/pubmed/18301122
"After controlling for age, weight, height and smoking history, BMD among SSRI users was 5.6% lower at the femoral neck (P=0.03), 6.2% lower at the trochanter (P=0.04) and 4.4% lower at the mid-forearm (P=0.03) than nonusers."
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