Very promising theory on PSSD being caused by changes in Kisspeptin expression

This is for hypothesis and even educated speculation.
Brain food
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Re: Very promising theory on PSSD being caused by changes in Kisspeptin expression

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A new study about Kisspeptin and fertily is published on September 6, 2022

Use of kisspeptin to trigger oocyte maturation during in vitro fertilisation (IVF) treatment
Bhavna Sharma1†, Kanyada Koysombat1†, Alexander N. Comninos2, Waljit S. Dhillo1,2‡ and Ali Abbara1,2*‡
https://www.frontiersin.org/articles/10 ... 72137/full
Brain food
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Re: Very promising theory on PSSD being caused by changes in Kisspeptin expression

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I found this link about a clinical trial.

Effects of kisspeptin administration in women with hypoactive sexual desire disorder: a randomized clinical trial

https://spiral.imperial.ac.uk/handle/10044/1/99419
Brain food
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Re: Very promising theory on PSSD being caused by changes in Kisspeptin expression

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Figure 2 of this study explains the connection between Kisspeptin in the brain and other parts of the body.

So there is a direct connection between Kisspeptin, VEGFA and angiogenesis. Kisspeptin and VEGF are two different theories on the RxISK Research Forum.

https://rbej.biomedcentral.com/articles ... 511-x#Fig2
thepineapple
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Re: Very promising theory on PSSD being caused by changes in Kisspeptin expression

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Brain food wrote: Fri Nov 04, 2022 11:16 am Figure 2 of this study explains the connection between Kisspeptin in the brain and other parts of the body.

So there is a direct connection between Kisspeptin, VEGFA and angiogenesis. Kisspeptin and VEGF are two different theories on the RxISK Research Forum.

https://rbej.biomedcentral.com/articles ... 511-x#Fig2
is there any relation to other symptoms like emotional numbness? In general not just sexual anhedonia which seems to be correlated
Brain food
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Re: Very promising theory on PSSD being caused by changes in Kisspeptin expression

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thepineapple wrote: Sat Nov 05, 2022 12:02 pm
Brain food wrote: Fri Nov 04, 2022 11:16 am Figure 2 of this study explains the connection between Kisspeptin in the brain and other parts of the body.

So there is a direct connection between Kisspeptin, VEGFA and angiogenesis. Kisspeptin and VEGF are two different theories on the RxISK Research Forum.

https://rbej.biomedcentral.com/articles ... 511-x#Fig2
is there any relation to other symptoms like emotional numbness? In general not just sexual anhedonia which seems to be correlated
Yes. Look at this review entitled “Current Perspectives on Kisspeptins Role in Behaviour”. Here are some quotes:

“ Moreover, several species like humans have evolved to gain reward and satisfaction from sex and its precursors (sexual desire and arousal) (4). Taken together, it is therefore conceivable that reproductive behaviour, mood and emotions are mediated by similar hormonal mechanisms, in a presumed drive towards successful reproduction.”

“ Emerging data from animal models and human studies reveals that outside of the classical reproductive axis, kisspeptin also modulates reproductive behaviour, mood and emotions, in part at least through its extensive distribution in the limbic system (8–11).”

“Moreover, in response to sexual images, kisspeptin was observed to activate limbic structures (including the hippocampus) more in men with lower baseline reward behavioural scores, which is highly relevant given that human sexual behaviour is closely associated with pleasure and reward. Of note, very recent data reveals that using the same administration protocol, kisspeptin does not affect brain responses to visual food stimuli or appetite parameters in healthy young men, assessed by fMRI and psychometric tests respectively (80), indicating that kisspeptin’s effects on limbic brain regions are specific to sexual and emotional stimuli.”

“ In addition to modulating human brain processing during stimulatory tasks, kisspeptin’s effects on resting brain connectivity have also been explored. Resting brain connectivity constitutes an important element of human behaviour (82) with the default mode network being the principle of these (83). In a subsequent fMRI analysis of healthy heterosexual men, peripheral administration of kisspeptin was observed to modulate the default mode network, which correlated with enhanced limbic brain activity in response to visual sexual images (84). Moreover, kisspeptin’s modulation of this network was greater in men with less reward drive and correlated with reduced sexual aversion (84).”

“Bonding Behaviour

Attachment and emotional union with a partner are important components in mammalian reproduction (85). To date, kisspeptins role in bonding behaviour has only been explored in humans. Using fMRI, peripheral administration of kisspeptin to healthy men has been shown to enhance limbic brain activity, in response to non-sexual couple-bonding images (78). Specifically, this was observed to occur in the thalamus and globus pallidus, which are brain regions implicated in romantic love (86, 87), as well as the amygdala, also implicated in bonding (87). From a functional perspective, kisspeptin’s enhanced activation of the amygdala correlated with improvements in positive mood (78), implicating kisspeptin in the processing of bonding stimuli, which is important in driving reproduction from a behavioural level.”

Then there’s an entire section on Mood and Emotions that explains studies examining Kisspeptin’s role in depression, anxiety, fear and another entire section on Interplay with Downstream Systems to Modulate Behavior. I won’t copy and paste these here because they’re so long but Kisspeptin interacts with a lot of neurotransmitters that are normally studied by psychiatrists.

https://www.frontiersin.org/articles/10 ... 28143/full
Brain food
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Re: Very promising theory on PSSD being caused by changes in Kisspeptin expression

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Ask Dr. David Healy. He spoke to the researchers at Imperial College London who are doing these trials. However, I personally don’t think that adding external Kisspeptin will bring back libido or sexual function in PSSD. I believe there are ways to test for Kisspeptin levels, but the test is only done in University research studies. I would definitely get tested for low Kisspeptin levels before experimenting with anything. My guess is that there is a problem with Kisspeptin receptors in the gonads.

https://rxisk.org/forum/kisspeptin/
Brain food
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Re: Very promising theory on PSSD being caused by changes in Kisspeptin expression

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Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1–PPAR-α–Kisspeptin–Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model

https://www.sciencedirect.com/science/a ... 8121002199
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