A more recent article on PSSD proposes a possible mechanism of action of SSRIs in the body

[lookingformeaning]

Article title: Trazodone and chlorpromazine a proposal treatment for syndrome post-finasteride
and syndrome of post-selective serotonin reuptake inhibitors (post-SSRI)

Abstract:
Erectile dysfunction caused by medications are probably caused by the disconnection of synaptic circuits responsible
for linking libido to erection. For instance, it is well known that sexual dysfunction may occur in patients treated with
antidepressants like selective serotonin reuptake inhibitors, syndrome known as (post-SSRI). A similar side effect has
been also reported during treatment with finasteride, an inhibitor of the enzyme 5alpha-reductase, for androgenetic
alopecia. Interestingly, sexual dysfunction persists in both cases after drug discontinuation. Trazodone is a
multifunctional drug with hypnotic actions at low doses due to blockade of 5-HT2A receptors, as well as H1 histamine
receptors and α1 adrenergic receptors therefore this drug can cause severe priaprism as a side effect and in many cases
causing penile necrosis or permanent loss of erectile function. Thus the antipsychotic like chlorpromazine also induce
priapism because the alpha receptor occupancy property of those drugs. Therefore we propose that these drugs can
restore libido synaptic circuits, and trazodone or antipsychotic drugs such as chlorpromazine can also be a treatment
for post-finasteride syndrome and post-SSRI.

Bibliographical reference
Eric Almeida Xavier * (article's author)
Institute of Chemistry of University of São Paulo (USP). Avenue. Prof. Lineu Prestes, 748 - Cidade Universitária.
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(01), 075–080
Publication history: Received on 28 May 2023, revised on 08 July 2023, accepted on 11 July 2023
Article DOI: https://doi.org/10.30574/wjbphs.2023.15.1.0299
Full article: https://wjbphs.com/sites/default/files/ ... 3-0299.pdf