This might be the key! Androgen function in the spotlight.

[fuckthisisscience]

Can you cite the three positive reports, please? What were their starting values and how high "above the reference range" did they go?

Please read the bottom line of my first post. I'm continously updating it. There you'll find the cases, as far as they're documented. Maybe I'll write down the third one later on, but this is not documented as good as the other ones.

Regarding the androgen receptor subject: I havent studied receptor functioning in detail, yet. I will do this as soon as I find the time to do.

[fuckthisisscience]

Since the excellent survey prepared by Axolotl and Awor (and which has been viewed together with the results by important scientists, who have greatly appreciated it) has shown that the syndromes caused by the various substances (ssri, finasteride, isotretinoin) have profiles overlapping, we firmly believe that all these different substances can contribute to cause a single clinical condition called "Post Drug Syndrome" in which there is a marked phenomenon of endocrine destruction.

Could you please link scientifical based posts of the people you mentioned? I read many theories but most of them is fantastical speculation, that has nothing to do with clinical reality and above all science (serotonin receptor hypotheses, dopamin deficiency etc.). It's all desperate speculation and waste of time.

What we need is scientific and symptom based approach. No hypothesis should be based on one single study of mice, and even less should anyone try random, clinically not approved drugs according to a spectacular theory.

Medicine most of the time makes sense - but not everything that makes sense is medicine.

[lw77]

The document, containing the theory concerning the PFS (but there are links with the other syndromes) will be released as soon as it is ready, I am not dealing with it therefore I do not know when it will be possible, I only know that there is a rich bibliography with many sources. I would like to underline that I don't need lessons on how medicine works and on what science is or is not @Fuckthisscience, better to make this clear immediately. We all get that we need experiments, but since soon you will graduate in medicine you should know that you need a lot of money that obviously we don't have.
We certainly do not need people (especially those who only have a "near degree") who go up to teach us what we must or should not do because we know perfectly well that too. Regarding the document that will come out I am not saying that it is a certain theory, I am only saying that it is a hypothesis supported by scientific articles and therefore it deserves consideration.
Nobody, especially me, here dreams of saying things that do not derive from a minimum of scientific basis and I strongly advise you not to insinuate it, since so far you have only said trivial things and that we already knew.

[enriqueiglesias]

I don't say testosterone is not an issue, but I would actually say it is possibly in many cases rather a symptom than an important cause. Firstly, I have no or only minor issues with libido, in other words I can get horny. But more centrally: if testosterone were the issue, or some other hormonal imbalance, one would probably at some point, probably even several times, in one's life have felt something very similar, with similar totally "numb" penis, even with erection and at the height of arousal. But no, while things could be normally "bad", they were not in the almost "dead" spectrum of bad or so completely contradictory that some sort of stimulation or arousal is possible, but actual feeling never arrives. And one could have really, really bad or weak orgasms, but not so that one literally feels nothing, even while the body is going through all the physical processes for several seconds. Etc.
Indeed "numb penis" would be one of the main issues on the internet, and scientists testing Viagra would say "f--k this, we have more important issues"... Not even close.
Depending on how vague you are willing to get, you can always bend it so that anything is comparable, that's why it's important that one can be honest with oneself and even notice things correctly. But aside from that, there is typically too much of an overgeneralization of a particular type of symptoms, like saying libido is gone, when one can also have libido but numb penis (between 60% and 90% or so numb).

[Truskawa]

I had a huge window only after I discontinued Clomid (I had taken it for a month before, 25mg every other day). Now I am impotent again.
Why is that? Isn't it weird?

[Northern_Star]

Hi! The admins of propeciahelp have now published their thoughts on what we call the Post-Androgen Deprivation Syndrome. lw77 has mentioned the document before and it is highly relevant to the discussion here.

[Markc1113]

I just switched to Defy Medical In Florida for my trt. They have me starting a new protocol that I hope works. Test cyp 200mg/ml .25 mwf, hcg 300iu mwf, and .125 anastrazole mwf. If my dht which is low for my test levels doesn’t increase they may incorporate some test cream as well to bring it up.

[kamil1234]

My results after a month of withdrawal. Citalopram 22 days from November 1, 2017. In addition, in 2018, I was diagnosed with Borelize, Mycoplasme, and Yersine. Half a year of antibiotic treatment. Now I can get an erection from porn, without stimulation, sometimes from thoughts. What helped me was the St. John's wort laif900. I remember drinking tea from St. John's wort, it reversed my numbness in the penis, but for a very short time. Then I took pills and it helped calm down. After drinking beetroot juice for the night, I had erotic dreams. Only once, because I don't have a juicer, and my aunt made my juice. I'm interested in one thing. On Monday, I took 25mg dheas and my testicles started to hurt, but it stopped. Zinc eased the pain. After taking copper, my testicles also hurt. What if you add progesterone to testosterone? There are journals of people who have recovered with progesterone. I also read how one person recovered from a ssri (paroxetine) drug taking 60mg zinc per day. Commentary on my statement is welcome.
Prolactin (PRL) 8.19 ng / ml 2.10 - 17.70
Progesterone (PGN) 1.93 ng / ml 0.28 - 1.22
Estradiol (E2) 35.31 pg / ml 0.00 - 39.80
Testosteron (TTE) 577,7 ng/dl 164,9 — 753,4
Folliculotropin (FSH) 6.94 mIU / ml 1.40 - 18.10
Luteotropin (LH) 4.46 mIU / ml 1.50 - 9.30
Cortisol 29.59 μg / dl 4.30 - 22.40
ACTH - adrenocorticotropic hormone (L63) 45.5 pg / ml 7.2 - 63.6
Aldosterone (I15) 9.67 ng / dl 1.97 - 26.00
Dihydrotestosterone (DHT) 1466,6 pg / ml 250-990 pg/ml
Dehydroepiandrostendion sulphate (DHEA-S) 711.60 μg / dl 211.00 - 492.00
Free testosterone (O41) 22.19 pg / ml 4,5 - 42 pg/ml

[Halan]

Very interesting, thanks for the post!
When you talk about supraphysiological testosterone levels, how much is this? something like 1200 ng/dL?
My levels are 400 ng/dL, not so low but could be higher since I haven't 30yo yet.

The problem with supraphysiological is the risk of prostate enlargement.

[Amisrableguy]

I can confirm trt does not work for me or pssd!
I tried it no results of benefits!

I might have got mines from trazdone