SNRI ( like Venlafaxine ) and others new poisons like Vortioxetine, etc - Hormonal Values

[Coraggio]

SSRI alter steroidogenesis for sure like Finasteride. While Finasteride is known to inhibit 5-Alpha reductase, and so the conversion of Testosterone in Dihydrotestosterone,
SSRI are found to change others enzymes activity like 3-Beta HydroxySteroid Dehydrogenase and 3Alpha HydroxySteroid Dehydrogenase that are very important for normal human androgens and hormones.

Here articles about SSRI 's hormanal dysruption activity:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670606/
http://orbit.dtu.dk/en/publications/eff ... 0c10).html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23979/


WHY do hormonal test are so Important? Well, if we have noraml testosterone but High progesterone, For exemple, progesterone inhibits testosterone action. it is recently found that progesterone decrease testosterone uptake by both Brain and Testis of 70%!! this can explain our condition alone. Also progestrone is recently found downregulate SERT in colon ephitelium, so Progesterone can mimicks itself SSRI activity. It's very probable that we have not only one hormanal values altered.

View this image for understending androgens pathway





So if you have taken this drug you MUST test These Hormones in the same Blood Sample:

- LH
- FSH
- ACTH
- PRL
- TSH- Reflex
- DHEA-S
- Progesterone
- (17 - OH - Progesterone)
- Delta4 Androstenedione
- Testosterone
- Free testosterone
- 17- Beta estradiol
- Dihydrotestosterone, it may be a little expensive but please do it
- (Pregnanolone)
- Allopregnanolone ( known as Pregnan 3Alpha-17- diol- 20- one)
- 3Alpha Androstanediol ( known also as 5α-androstane-3α,17β-diol or 3Alpha-diol)

Note: hormones in parenthesis are optional

If could be expensive but show the articles above to your endocronocrinologist and try to get a prescription explaing that PSSD is very similar to PFS, etc, etc, etc,
If you note that some hormone is high or low, PLEASE report here the value with normal range( Every lab has its normal range that can differ from the others ).

Sorry for my bad English. This list can be updated so check it out this thread regularly.

Coraggio!!

[GIXXER]

I have a Dr. appointment booked for Wednesday.

[Missingno]

I can't afford to retest my levels, but I do have my results from several years ago. I was already trialing hormone replacement therapies so the results may not be particularly useful.

I was on amitriptyline, then Prozac, then Effexor, starting before puberty so I never had a clear onset.

Age 21, about 5 years after withdrawal (2010)
Prior to this test I had tried taking hCG, transdermal testosterone and hydrocortisone. I had stopped them all for some time before testing however.

Endocrinology
• TSH 0.76 uU/mL 0.3 – 4.5
• T3 free 3.49 pg/mL 2.1 – 4.2
• T4 free 1.33 ng/dL 0.7 – 1.8
• Thyroid antibodies
• Ab to thyroglobulin <5 U/mL <100
• Anti-TPO 2 U/mL <16
• Transcortine 61 mg/L 20 – 50 High
• Cortisol free (8 AM) 12.4 ng/mL 10 – 30
• FSH 3.0 mIU/mL 2 – 15
• Estradiol 66 pg/mL <30 High
• Progesterone 0.92 ng/mL 0 – 1
• Testosterone 4174 pg/mL 3000 – 10000
• Testosteron free 162 pg/mL 50 – 280
• Testosterone liée 96.1 %
• SHBG 25 pmol/mL 20 – 55
• Androstanediol-gluc 6.51 ng/mL 3.4 – 22
• DHEA sulfate 193 ug/dL 200 – 610 Low
• Somatomedin-C (IGF-1) 636 ng/mL 190 – 490 High
• IGFBP-3 3.11 mg/L 2.96 – 4.96
• IGFBP-3/IGF1 1.29 mol/mol 0 – 4.5

Urin Endocrinology
• T3 0.26 ug/L
• T3 1030 pmol/24h 800 – 2500
• T4 0.58 ug/L
• T4 1930 pmol/24h 550 – 3160
• Cortisol libre 51.6 ug/24h 10 – 100
• 17-ketosteroids chromatography
o Androsterone 4.67 mg/24h 2.10 – 6.30
o Etiocholanolone 4.21 mg/24h 1.90 – 5.70
o DHEA 0.13 mg/24h 0.05 – 1.40
o 11-Keto-androsterone 0.46 mg/24h 0.05 – 0.80
o 11-Keto-etiocholanolone 1.24 mg/24h 0.05 – 1.00 High
o 11-OH-androsterone 1.81 mg/24h 1.20 – 2.60
o 11-OH-etiocholanolone 1.03 mg/24h 0.05 – 2.10
o Total 17-Ketosteroids 13.55 mg/24h 0.40 – 1.40
• Pregnanediol 1.73 mg/24h 0.40 – 1.20 High
• Pregnantriol 1.19 mg/24h 0.40 – 1.40
• 17-OH steroids-chomatrography
o Tetrahydrodeoxycortisol 2.24 mg/24h 0.05 – 2.30
o Tetrahydrocortison 8.00 mg/24h 2.40 – 5.20 High
o Tetrahydrocortisol 3.95 mg/24h 1.50 – 3.30 High
o Allo-tetrahydrocortisol 3.69 mg/24h 1.00 – 2.60 High
o Total 17-OH-steroids 17.88 mg/24h 6.10 – 11.70 High
• Aldosterone 25 ug/24h 5.0 – 20 High
• Growth hormone 9.08 ng/24u 0 – 10
• 6-sulfatoxy-melatonin 29.5 ug/24h 15.6 – 58.1

Based on those results the doctor prescribed testosterone, DHEA and also progesterone (To lower estrogen)
This test was a few months later. Only posting as it may be relevant to the next set of results.

TSH 2.24 uU/mL 0.3 - 4.5
T3 free 2.76 pg/mL 2.1 - 4.2
T4 free 1.13 ng/dL 0.7 - 1.8
Estradiol 23 pg/mL <30
Estrone 33 pg/mL 10 - 60
Progesterone 5.2 ng/mL 0 - 1 High
Testosterone 3906 pg/mL 3000 - 10000
Testosterone free 168 pg/mL 50 - 280
Testosterone liée 95.7 %
SHBG 17 pmol/mL 20 - 55 Low
Androstanediol-gluc 13.12 ng/mL 3.2 - 22
DHEA sulfate 235 ug/dL 200 - 610

I discontinued the treatment and got some more tests done a year or two later, age 22 or 23:

Prolactin 5.3 ng/mL 1 - 19
LH 3.7 mIU/mL 3 - 18
FSH 4.5 mIU/mL 2 - 15
Estradiol 12 pg/mL <30
Progesterone 0.90 ng/mL 0 - 1
Testosterone 4959 pg/mL 3000 - 10000
Testosterone free 187 pg/mL 50 -280
SHBG 30 pmol/mL 20 - 55
DHEA sulfate 168 ug/dL 200 - 610 Low
Somatomedin-C (IGF-1) 375 ng/mL 190 - 490
IGFBP-3 5.13 mg/L 2.96 - 4.96 High

Urine:
Cortisol libre 52.7 ug/24h 10 - 100
17-OH steroids chromatography:
Tetrahydrodeoxycortisol 1.37 mg/24h 0.05 - 2.30
Tetrahydrocortison 4.19 mg/24h 2.40 - 5.20
Tetrahydrocortisol 3.02 mg/24h 1.50 - 3.30
Allo-tetrahydrocortisol 1.47 mg/24h 1.00 - 2.60
Total 17-OH-steroids 10.05 mg/24h 4.10 - 11.70

[GIXXER]

Ill post my full results later today. A quick look though my Dhea Sulphate is a little low at 4.2 normal range is 4.6-18.2 Not sure if it means anything.

Also my progesterone is 0.8


- LH 3.0 IU/L
- FSH No result
- ACTH Still Waiting
- PRL 6.3 ug/L
- TSH- Reflex 1.86 mU/L
- DHEA-S 4.2 umol/L LOW
- Progesterone 0.8 nmol/L
- (17 - OH - Progesterone) not tested
- Delta4 Androstenedione
- Testosterone 13.4 nmol/L
- Free testosterone not tested
- 17- Beta estradiol 126 pmol/L
- Dihydrotestosterone, it may be a little expensive but please do it-not tested
- (Pregnanolone)-not tested
- Allopregnanolone ( known as Pregnan 3Alpha-17- diol- 20- one) not tested
- 3Alpha Androstanediol ( known also as 5α-androstane-3α,17β-diol or 3Alpha-diol) not tested