PSSD Forum

Good news that he is still doing something.. but it seems to me that few persons tried flibanserin with limited succes. Did he tell when he gonna publish study?

Btw i didnt participate in his study but i had short conversation with him

Janie, do you know more about the serotogenic neurotoxicity theory? That sounds bad, iirc people get something similar from mdma abuse and it's irreversible

Unfortunately I don't know more. As the study goes rather slow as I see, I expect it to be published next year, but this is just my thought.

My friend who suffered a similar reaction to escitalopram (after kindling) was just diagnosed with neurotoxicity (toxic encephalopathy) as lesions were showed in his brain on MRI picture.
Even if neurotoxicity is involved, I DON'T think it is fully irreversible, as many people reported at least temporary relief (from substances like Bupropion). I think if the nervous system cells used for signalling were totally destroyed by the toxin, there wouldn't be any reports about temporary relief or any full recovery story neither (like the one from Mianserin which is promising to me as the same SSRI - escitalopram was involved in the damage). It's still very hard but this can give us a bit of hope...

Hmmm i recovered for 2 weeks after drug cessation and then crashed.

lost_soul wrote:Janie, do you know more about the serotogenic neurotoxicity theory? That sounds bad, iirc people get something similar from mdma abuse and it's irreversible

Keep in mind many have gotten pssd from low doses and after 1-4 pills, which literature shows is inactive at 5ht. We can poke holes in theories all day. Let's not fret over something that isn't confirmed.

Janie wrote:Unfortunately I don't know more. As the study goes rather slow as I see, I expect it to be published next year, but this is just my thought.

My friend who suffered a similar reaction to escitalopram (after kindling) was just diagnosed with neurotoxicity (toxic encephalopathy) as lesions were showed in his brain on MRI picture.
Even if neurotoxicity is involved, I DON'T think it is fully irreversible, as many people reported at least temporary relief (from substances like Bupropion). I think if the nervous system cells used for signalling were totally destroyed by the toxin, there wouldn't be any reports about temporary relief or any full recovery story neither (like the one from Mianserin which is promising to me as the same SSRI - escitalopram was involved in the damage). It's still very hard but this can give us a bit of hope...

There is literally zero evidence that SSRIs can cause neurotoxicity at therapeutic doses, unless you suffered from Serotonin Syndrome. If we want to be taken seriously by the medical community, we need to completely disband the notion that SSRIs can cause neuronal death, especially since there's evidence to the contrary.

https://www.researchgate.net/profile/No ... 000000.pdf

siebs1122 wrote:

Janie wrote:Unfortunately I don't know more. As the study goes rather slow as I see, I expect it to be published next year, but this is just my thought.

My friend who suffered a similar reaction to escitalopram (after kindling) was just diagnosed with neurotoxicity (toxic encephalopathy) as lesions were showed in his brain on MRI picture.
Even if neurotoxicity is involved, I DON'T think it is fully irreversible, as many people reported at least temporary relief (from substances like Bupropion). I think if the nervous system cells used for signalling were totally destroyed by the toxin, there wouldn't be any reports about temporary relief or any full recovery story neither (like the one from Mianserin which is promising to me as the same SSRI - escitalopram was involved in the damage). It's still very hard but this can give us a bit of hope...

There is literally zero evidence that SSRIs can cause neurotoxicity at therapeutic doses, unless you suffered from Serotonin Syndrome. If we want to be taken seriously by the medical community, we need to completely disband the notion that SSRIs can cause neuronal death, especially since there's evidence to the contrary.

https://www.researchgate.net/profile/No ... 000000.pdf

No, I don't agree. Of course there is not much evidence about EVERY possible mechanism that could have led to these permanent changes. That's why we don't know why PSSD happens. Ruling out neuronal damage is just totally stupid when we know nothing in fact.

Peter Breggin wrote: Kalia et al. found that 4 days of high doses of serotonin-stimulating drugs, including Zoloft and Prozac, caused abnormalities in the body and the axons of neurons. Prozac more often produced a large swelling of the neuronal body. Zoloft caused swollen and truncated axons and, in some cases, made the cells look corkscrew in some form. The study raises questions about the survivability of the damaged cells

I was thinking that if that upcoming study is really conclusive it would be a much better case to bring to court. We could really use more than one study though!

Well, in both cases that I mentioned the neurotoxicity theory and diagnosis came from the medical community itself. I don't know whether it's involved in PSSD or not, although its undeniable that there are similarities in symptoms. Actually, there are suggestions that SSRIs can cause Serotonin Syndrome even in therapeutic dosages. Again, I'm not saying this is the cause, but I don't think we can rule this out. There are cases of brain damage from only one MDMA pill as well.

"SSRI toxicity and other adverse drug reactions can occur with overdose, in combination with other medications, or, infrequently, at therapeutic doses. (See Etiology.)"
http://emedicine.medscape.com/article/821737-overview

But still there is question about that 2 weeks improovement after drugs cessation ...few persons can confirm that it was case for them.
Ther are 3 scenarios
1. Few doses and instant PSSD
2. PSSD during long term use ssri
3. PSSD after cessation (worsen then SSRI induced SD)