Progesterone

This is a place to post research you have done on the topic along with your conclusions.
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Ghost
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Progesterone

Unread post by Ghost »

Here I will by combining previous threads on Progesterone, and hoping to continue research into this area.

I believe that Progesterone levels could be playing a large role in PSSD.

I'll begin with some studies:



Effects of progesterone on the sexual behavior of castrated, testosterone-treated male cynomolgus monkeys (Macaca fascicularis).
https://www.ncbi.nlm.nih.gov/pubmed/9226343
P treatment, which resulted in high plasma P levels (about 44 ng/ml), produced decrements in measures of male sexual behavior and motivation...P did not decrease plasma T levels or change them in any way (about 850 ng/100 ml throughout)
The following study is really exciting because it ties Estradiol (E2) to Progesterone (PROG) in a way that I haven't seen anyone do before. If this is the case - follow my logic: Increased PROG could decrease E2 binding in the POA. First of all, this could explain why E2 treatment helps with PSSD, and could explain how high PROG levels in PSSD sufferers could be giving symptoms that are reversed by E2 in rats. Note also that E2 plays a big role in SERT expression. Should this be the case, lowering E2 in the POA (which is heavily tied to sex) could decrease SERT expression. As I've shown before, this could explain 5-HT1A AR desensitization, and explain why 5-HT1A ARs un-couple from GIRK channels - leading to increased 5-HT levels.

This also tells you that your urologists and endocrinologists have been lying to you. They often state that if Testosterone levels aren't impacted that there can be no hormonal change that is causing your ED. This is false and shown by the above study and the one below. PROG can decrease sex drive without touching T levels. So you can have high T, but low drive. In fact, this is how they currently treat sex offenders - with Progesterone analogs.





Progesterone decreases mating and estradiol uptake in preoptic areas of male monkeys.
https://www.ncbi.nlm.nih.gov/pubmed/11790421
Synthetic progestins such as medroxyprogesterone acetate (MPA) are used widely in the treatment of male sex offenders. In male cynomolgus monkeys (Macaca fascicularis) treated with testosterone (T), both MPA and progesterone (P) had comparable inhibitory effects on male sexual motivation and behavior. To determine if P, like MPA, decreases endogenous T levels, plasma T and P levels were analyzed in weekly blood samples (N=186) from eight intact males, each paired with a sexually receptive female before, during, and after treatment with subcutaneous Silastic P implants (336 behavior tests). P treatment decreased sexual activity but not plasma T levels.

P, unlike MPA, did not affect the nuclear uptake of [3H]androgens by brain, but reduced by 80% the nuclear accumulation of [3H]E(2) in tissue samples containing preoptic area
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nasibi
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Re: Progesterone

Unread post by nasibi »

I will be experimenting with a progesterone antagonist in the upcoming months.
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marsupial
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Re: Progesterone

Unread post by marsupial »

But Ghost this theory could be easily verified. Its actualy what we did and it turned out false - most pssd sufferers dont have high plasma P
Juvo
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Re: Progesterone

Unread post by Juvo »

marsupial wrote:But Ghost this theory could be easily verified. Its actualy what we did and it turned out false - most pssd sufferers dont have high plasma P
Not many on the forum have measured their prog. Of the ones that have most DO have high prog.
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Ghost
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Re: Progesterone

Unread post by Ghost »

I've collected data from 4 males on the forum that I'm aware have taken the test (I've only collected male levels because they are usually quite different than female ones and with these types of levels sex matters a lot). 2 have very high levels, and the other two are near the far upper limit of normal. If others have gotten levels tested, I am excited to see what their results say.
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mcmare
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Re: Progesterone

Unread post by mcmare »

cmon guys, everybody here should test for progesterone, after all it's not so expensive.
Cipralex (escitalopram) from september 2012 to september 2013. Forgot exact dosage. PSSD improving since taking 20g MSM powder per day, no porn and regular heavy lifting fitness routine. Stay strong!
Juvo
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Re: Progesterone

Unread post by Juvo »

mcmare wrote:cmon guys, everybody here should test for progesterone, after all it's not so expensive.
This ^. To reiterate, elevated PROG is the one thing tying us all together that we know of. Not everyone here has low testosterone, and as the study that Ghost posted, you can have normal testosterone levels and crippled sexual dysfunction from Prog.
Glitch
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Re: Progesterone

Unread post by Glitch »

Thank you, Ghost. I was getting antsy for new information/findings!

My progesterone test through quest labs:
17-OH-PROGESTERONE,LC/MS/MS = 87
Reference Range:
42-196
(ng/dL)

My progesterone is very good unless there is another standard progesterone test. I don't know what the fuck "17-OH" means.
Juvo
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Re: Progesterone

Unread post by Juvo »

Glitch wrote:Thank you, Ghost. I was getting antsy for new information/findings!

My progesterone test through quest labs:
17-OH-PROGESTERONE,LC/MS/MS = 87
Reference Range:
42-196
(ng/dL)

My progesterone is very good unless there is another standard progesterone test. I don't know what the fuck "17-OH" means.
Yes that is different than progesterone
Glitch
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Re: Progesterone

Unread post by Glitch »

Yeah, I thought so! I was reading about it and it seemed that way. I don't think I've ever had that test done in my life. On the 31st of this month, I will request it.

So it aligns with the estrogen idea but does it make sense with the DHT as well?

Also, for you guys that have high progesterone, is your 17-OH Progesterone off too as a result?
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