Blackout estradiol trial

[namaste]

Just curious - how did you decide what type of dose to use for the estradiol patch? Was it labeled on the box?

I've read that you shouldn't go over 50-75 mg of mesterolone a day, otherwise you risk suppression.

Just remember, it might take a few weeks to feel different. I wish you the best of luck!

I decided to start with the available lowest dose patch, but it may be too low perhaps. Don't know.

Regarding mesterolone, my story begins a few months before the start of sertraline intake, precisely when during my worst -and last- depressive-anxious-psychotic crissis, I decided to take up to 100 mg mesterolone alone. Took it 2 weeks, the spike in my already monster libido was incredible, but then suppression came in with full force. Since mesterolone doesn't aromatize, I'm sure that by that time, not only did I lost my own testosterone production, but I was depleted of estradiol. Then a couple months later began a PCT to restore my axis while depression was at its peak, then began with sertraline, and the nightmare began. I'm sure that something related to my hormonal suppression at that time was the brake that allowed the switch of sertraline to turn me off permanently. That's why I think estradiol could really have a huge role on the PSSD mechanism. That, and the fact I explained in the opening message, when I got all my libido back during a single night when my estradiol was super high during a testosterone trial a year later -and then I took arimidex, believing that it could help, but I guess it did just the opposite and that's why testosterone alone did nothing.

If you are a male, then I would definitely recommend you to take Testosterone along with it, preferably injections. Moreover you can use HCG along with it, it will prevent any testis atrophy. Hcg also spikes estradiol by itself. No need for seperate estradiol intake.

I have taken HCG numerous times in the past, but I don't know if I became tolerant to it since during the last time it did nothing to raise my T. On the other hand, since I mistakenly began taking arimidex every time I did testosterone/HCG, I didn't allow the estradiol to raise as I desire now.

He is attempting to replicate the recent rat study. I'm not a doctor, but I would say he should stick with the regimen he's on now, as it most closely matches the stack that led to positive results.

Yes, I guess that exogen estradiol would rise it more than just taking HCG or testosterone and let it aromatize. But on the other hand I'm afraid how much will it rise, since I don't have money to monitor it frequently at least during the first weeks.

It sounds like you are being cautious, which is good. If you decide to continue with treatment, I'd stay with the lowest doses for at least a few weeks (the treatment period was 3 weeks in the study). No one will blame you if you discontinue for the sake of your health though.

[Ghost]

I'm wishing you the best of luck! This is very brave and I hope beyond hope that it pays off for you.

[namaste]

I was just reading that excess progesterone blocks the conversion of testosterone to DHT. Has anyone found literature showing that increased DHT can lower prog levels? I'm curious if this plays into the positive effects of the estradiol+DHT stack.

[Juvo]

I was just reading that excess progesterone blocks the conversion of testosterone to DHT. Has anyone found literature showing that increased DHT can lower prog levels? I'm curious if this plays into the positive effects of the estradiol+DHT stack.

I have the same question. Unfortunately, it's super difficult to find any literature on this. You are right though. Progesterone is a 5ar inhibitor

[namaste]

Hey blackout - any updates on the trial? Hope all is going well.

[Blackout]

Nothingness, as it uses to be the norm with me trying experiments.

Today I took the last mesterolone pill of the box, but I'm not sure to continue with it due to financial difficulties as I stated at first. I WOULD do, if I could, but I can't. I'm continuing with the estradiol patches at this very low dose but I guess it's enough time to say that at least this dose is doing nothing for me -neither good or bad-. Patches are expensive, and I was considering to do generic injections of estradiol valerate -plus prasterone/DHEA-, but with my good luck -sarcasm-, they were discontinued just last month. They were by far the cheapest estradiol option here. So I will continue with the patches, but will be quite difficult to maintain a higher dose for long time when I up the dose, because I will increase it, but I don't know when.

[Juvo]

Nothingness, as it uses to be the norm with me trying experiments.

Today I took the last mesterolone pill of the box, but I'm not sure to continue with it due to financial difficulties as I stated at first. I WOULD do, if I could, but I can't. I'm continuing with the estradiol patches at this very low dose but I guess it's enough time to say that at least this dose is doing nothing for me -neither good or bad-. Patches are expensive, and I was considering to do generic injections of estradiol valerate -plus prasterone/DHEA-, but with my good luck -sarcasm-, they were discontinued just last month. They were by far the cheapest estradiol option here. So I will continue with the patches, but will be quite difficult to maintain a higher dose for long time when I up the dose, because I will increase it, but I don't know when.

Hey blackout. Be sure and continue the trial a couple more weeks if this is your first week in. Good luck.

[namaste]

Nothingness, as it uses to be the norm with me trying experiments.

Today I took the last mesterolone pill of the box, but I'm not sure to continue with it due to financial difficulties as I stated at first. I WOULD do, if I could, but I can't. I'm continuing with the estradiol patches at this very low dose but I guess it's enough time to say that at least this dose is doing nothing for me -neither good or bad-. Patches are expensive, and I was considering to do generic injections of estradiol valerate -plus prasterone/DHEA-, but with my good luck -sarcasm-, they were discontinued just last month. They were by far the cheapest estradiol option here. So I will continue with the patches, but will be quite difficult to maintain a higher dose for long time when I up the dose, because I will increase it, but I don't know when.

Sorry to hear. It could in-fact be that your estradiol dose is too low, as you stated. I believe lost soul took a much higher dose, although his might have been oral.

I'm not going to suggest that you ramp up your dose too much, if at all. Whatever you do, though, stay healthy and keep us updated. Best of luck.

[forexworld12]

Well the person who tried this before you reported that it took him 19 days to start noticing the reversal of pssd and he was on 1 mg estrogen. Dont know if the dose you are trying plus the patch will work but you need to have lots of patience

[fema4psyciatrists]

watching with interest!