Inositol Powder
Posted: Thu Jan 22, 2015 10:46 pm
PharmD on Fri Jan 28, 2011 3:12 pm
First of all, a big thank you to the creator of this forum. I applaud your efforts in sharing your experiments with others in hopes for finding a solution to PSSD.
I have found inositol to be an effective agent in treating my social anxiety disorder (SAD) (if only I had discovered it before Paxil damaged my body pale ). This stuff is amazing! I have been keeping a log for the past 6 days, and I am happy to report that I have had consistant relief from SAD on every single one of those days. Trials show a benefit by week 4 but I can definately say that I am getting immediate relief from this stuff. Inositol has also been found to treat depression and OCD with comparable efficacy to SSRIs with a MUCH better side effect profile, so keep this in mind if you suffer from PSSD, dropped the SSRIs, and are still looking for a viable alternative to treat your depression, OCD, anxiety etc. Dose is in the 6 gram - 18 gram range daily (can be in divided doses as well).
I thought I might contribute to this board as I am self experimenting with the effects of Inositol on my PSSD.
Method of Action: Most conventional psychotropics in use today act at receptors on the cell membrane. Inositol, which acts at the second-messenger intracellular level, is a truly novel psychotropic agent. Chronic inositol administration has been found to induce a significant increase in striatal dopamine2 receptor density (Bmax), but not affinity, with a slight increase in 5HT2 receptor density, but not affinity. The changes observed in striatal D1-D2 balance will result in marked changes in activity in the cortical-striatal-thalamic circuit - and in the modultation of thalamic activation of the cortex and striatum. Inositol's effect on mGlu-1 receptors may modulate dopaminergic function indirectly and resent with biochemical and behavioral consequences of DA hyperactivity. (It is possible that Inositol and Serotonin Reuptake Inhibitors (SSRIs) converge to a common final, perhaps genetic, destination. It is also possible that Inositol actives a cascade of events (as do other antidepressants), but at a later point or a different cascade that eventually interacts of converges with the events related to other antidepressant drugs.) Inositol is a key intermediate of the phosphatidyl-inositol (PI) cycle - a second messenger system used by several noradrenergic alpha, several types of serotonergic and cholinergic nerve receptors and is a rate-limiting step in the synthesis of PI - considered a saturated system. No changes in mono-aminergic systems follow acute or chronic Inositol administration. Inositol is responsible for the production of second messengers Inositol triphospahte3 (IP3) and DAG and regulation of phospholipase C. Inositol functions as cell growth factor by stimulating fat used to construct myelinated nerve materials. In animal models, chronic dietary inositol significantly elevates cellular Inositol levels in the cortex (36%) and hippocampus (27%) but not in the striatum or cerebellum. Regional differences in inositol uptake by the brain may shed light on the mechanism of action of lithium in different brain regions. Cerebellar granule cells in culture, which do not accumulate high levels of inositol, are also less susceptible to inositol-induced reversal of the biochemical effects of lithium. (Introcerebroventricular replenishment of lithium-induced depletion of inositol reverses lithium's effects on behavior.) Inositol also reverses desensitization of serotonin receptors.
(FYI my PSSD is manifests as genital numbness and premature ejaculation (<--Successfully treated with Tramadol, numerous times))
My Log: (Dose is 6 grams twice daily)
Jan 24-27/11: No significant effect on my PSSD
Jan 28/11: I feel able to get aroused much easier when thinking about erotica. (Before I could be watching porn and struggle to get a hard-on).
First of all, a big thank you to the creator of this forum. I applaud your efforts in sharing your experiments with others in hopes for finding a solution to PSSD.
I have found inositol to be an effective agent in treating my social anxiety disorder (SAD) (if only I had discovered it before Paxil damaged my body pale ). This stuff is amazing! I have been keeping a log for the past 6 days, and I am happy to report that I have had consistant relief from SAD on every single one of those days. Trials show a benefit by week 4 but I can definately say that I am getting immediate relief from this stuff. Inositol has also been found to treat depression and OCD with comparable efficacy to SSRIs with a MUCH better side effect profile, so keep this in mind if you suffer from PSSD, dropped the SSRIs, and are still looking for a viable alternative to treat your depression, OCD, anxiety etc. Dose is in the 6 gram - 18 gram range daily (can be in divided doses as well).
I thought I might contribute to this board as I am self experimenting with the effects of Inositol on my PSSD.
Method of Action: Most conventional psychotropics in use today act at receptors on the cell membrane. Inositol, which acts at the second-messenger intracellular level, is a truly novel psychotropic agent. Chronic inositol administration has been found to induce a significant increase in striatal dopamine2 receptor density (Bmax), but not affinity, with a slight increase in 5HT2 receptor density, but not affinity. The changes observed in striatal D1-D2 balance will result in marked changes in activity in the cortical-striatal-thalamic circuit - and in the modultation of thalamic activation of the cortex and striatum. Inositol's effect on mGlu-1 receptors may modulate dopaminergic function indirectly and resent with biochemical and behavioral consequences of DA hyperactivity. (It is possible that Inositol and Serotonin Reuptake Inhibitors (SSRIs) converge to a common final, perhaps genetic, destination. It is also possible that Inositol actives a cascade of events (as do other antidepressants), but at a later point or a different cascade that eventually interacts of converges with the events related to other antidepressant drugs.) Inositol is a key intermediate of the phosphatidyl-inositol (PI) cycle - a second messenger system used by several noradrenergic alpha, several types of serotonergic and cholinergic nerve receptors and is a rate-limiting step in the synthesis of PI - considered a saturated system. No changes in mono-aminergic systems follow acute or chronic Inositol administration. Inositol is responsible for the production of second messengers Inositol triphospahte3 (IP3) and DAG and regulation of phospholipase C. Inositol functions as cell growth factor by stimulating fat used to construct myelinated nerve materials. In animal models, chronic dietary inositol significantly elevates cellular Inositol levels in the cortex (36%) and hippocampus (27%) but not in the striatum or cerebellum. Regional differences in inositol uptake by the brain may shed light on the mechanism of action of lithium in different brain regions. Cerebellar granule cells in culture, which do not accumulate high levels of inositol, are also less susceptible to inositol-induced reversal of the biochemical effects of lithium. (Introcerebroventricular replenishment of lithium-induced depletion of inositol reverses lithium's effects on behavior.) Inositol also reverses desensitization of serotonin receptors.
(FYI my PSSD is manifests as genital numbness and premature ejaculation (<--Successfully treated with Tramadol, numerous times))
My Log: (Dose is 6 grams twice daily)
Jan 24-27/11: No significant effect on my PSSD
Jan 28/11: I feel able to get aroused much easier when thinking about erotica. (Before I could be watching porn and struggle to get a hard-on).