Insights into the cause of PSSD

[Blauwasser]

@Jaxx

I am glad you brought up the aspect of safety. In short, Yes, I did it unsupervised. However, I had spent much thought on the proper procedure and possible safety hazards prior to the procedure. Furthermore, during previous years there have come up some great sources of information about fecal transplantation on the web. The reason for that is that in the case of severe chronic diarrhea fecal transplants have taking on a top notch position as means of treatment in modern medicine, beating any kind of conventional medical treatment in efficiency. Since many people in the USA did not have access to this unconventional treatment, a kind of DIY movement emerged.
A spendid example is this webpage:
https://thepowerofpoop.com/epatients/fe ... tructions/

Blauwasser

[Jaxx]

Yeah ive heard about a couple of hospitals doing this procedure with great success in the last couple year, although this was not related to the field of psychiatry/endocrinology however.
I dont question your story, but i am thinking how we can test if this would be a possible solution for others.

[Blauwasser]

I appreciate your concern and I consider it well justified. I strongly want to point out that, as of now, there is no scientific data that explicitly proves a microbiomal cause for PSSD. Nevertheless, I believe there is enough data to deduce a connection. I am afraid, though, that as long science does not pick up on that topic there will be no reliable route to test the broader applicability of this treatment other than giving it a try.

Blauwasser

[Jaxx]

I appreciate your concern and I consider it well justified. I strongly want to point out that, as of now, there is no scientific data that explicitly proves a microbiomal cause for PSSD. Nevertheless, I believe there is enough data to deduce a connection. I am afraid, though, that as long science does not pick up on that topic there will be no reliable route to test the broader applicability of this treatment other than giving it a try.

Blauwasser

I think you made a good point, and honestly, ive seen enough recoveries that cannot be explained easily by GP's or specialists. I am just thinking if this is something we can test as a commen factor (like high progesterone levels) to move forward to a suitable treatment.
In most cases we skip the step of identification and just test a treatment, but this one is too serious for that obviously.

Raven's test and progress does match this story quite nicely.

[Blauwasser]

In theory there are most likely traceable blood values commonly connected to PSSD. But these parameters tend to be the mediator of a condition and rarely the cause of it. Further, in the case of PSSD I believe that a disturbed Nitritoxid cycle is involved in the symptomatic and I am not aware of any common medical diagnostic procedure for that hormone.

I am new to this forum and not familiar with Ravens progress.

Blauwasser

[TalkingAnt]

I do not want to elaborate too much on this initial post of mine for the means of clarity.

Are you planning on writing a more detailed report of your experience, procedure, results, etc? Or are you hesitant to provide such details?

[Blauwasser]

@TalkingAntColony

Do not get me wrong; I do not want to give the impression of intending to withhold any kind of information or experience. It is just that over the years I have noticed that on online forums people tend to express their personal endeavor unsparingly detailed and quite elaborately right from the beginning, which I personally found difficult to go through by times, so I wanted to spare you guys from that. Further, I find it easier to unfold my details in a dialog, because then I can see what people want to know right away. So feel free to ask me anything you want and I do my best to answer it to your liking. Should this not be sufficient I will reconsider writing a complete report. Sorry for the missunderstanding.

Blauwasser

[TalkingAnt]

Fair enough. I will post some questions here:

1. Are their any articles or pieces of evidence that lead you to this theory?

2. Are there any cases of antibiotics causing PSSD-like symptoms? Or cases of something other than an SSRI messing up the gut microbiome and later causing sexual disorder?

3. What criteria did you use to choose a donor?

4. It sounds like you underwent multiple transplants? Is this how FT is normally done, or was there a reason you did multiple?

5. When did you first notice improvements in PSSD symptoms?

6. What was the general timeframe for the improvements? Within a few days? gradually over weeks? Etc.

7. Was genital numbness (aka lack of sensitivity, or lack of pleasurable touch) a symptom, and to what degree did it improve?

8. Is your sexual functioning and ability to experience sexual pleasure 100% recovered back to what it was before PSSD?

Your answers are much appreciated.

[DrugsAreBad]

It's an interesting idea, but if bifidobacteria and lactobacillus have something to do with this, than shouldn't eating yoghurt should have an effect?

[iull1k]

If it was simple like this, then probiotics would solve our issue. We often can see some improvements with use of probiotics here and on PFS forum. Neurosteroids and neurotransmitters are highly present in gut tissue, more then this 95% of body 5ht receptors are in gut. Neurosteroids have huge impact on gut contractions and motility. A lot of guys here developed IBS or other condition as a cause of SSRI use, and probiotics often tend to counterract this side effect. Because of altered gut function you can get less much less necessary substances, malabsorbtion because of too fast motility. Also gut function is linked to prostate function.
In fact, your diet, and manipulation of gut function, can solve some issues, like no junk food, healthy lifestyle, multivitamin use and so on, i highly doubt that this is the cause. If it was, then a lot of antibiotics users will get this sides. I don't know a single person who got genital anesthesia from antibiotics.