Urecholine (bethanechol)

[Dead]

So the dosage was 4x25mg per day? How many days until you saw improvements? Did you take 100 mg at once or spread out through the day? Thanks

[logicalscout]

I wonder if we could get the same effect by increasing acetylcholine by using CDP-Choline. It would be very hard for me to get this drug prescribed. It could explain why my libido goes worse after using Ritalin or Wellbutrin (which both have anti cholinergic effects).

[Snake]

My urologist told me literally to leave him alone because "it's not his job" XD

[TalkingAnt]

You can find urecholine online at the usual sources.

I'll give this one a shot eventually, seems theoretically interesting.

CuredPSSD, can you give a timeline of your events? Like:

Day 1: took 24mg
Day 21: took 4x25mg
Day 25: PSSD cured

Something like that.

Also, can you answer some other questions:

1. How was your sleep with PSSD, and has it changed after?
2. Were the PSSD improvements gradual or sudden?
3. How is your diet?
4. How often do you exercise?
5. What is your body weight?
6. What is your age?

[anacleta]

Treatment of Antidepressant-Induced Sexual Dysfunction - 1998
https://webcache.googleusercontent.com/ ... clnk&gl=sm
"Bethanechol is a cholinergic agonist that has occasionally been useful in reversing sexual dysfunction associated with TCAs and MAOIs.[70,71,72,73] Typical doses are 10mg to 20mg as needed or 30mg to 100mg daily in a divided dose. Potential side effects with bethanechol include diarrhea, cramps, and diaphoresis. No reports have evaluated or suggested the efficacy of bethanechol for treating SSRI-induced sexual side effects."


Sexual side effects of antidepressant drugs - 2012
https://www.researchgate.net/publicatio ... sant_drugs
"Antidote or Agonist Approaches: ... cholinergic bethanechol [66,67]..."
66. Gross MD. Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants. Am J Psychiatry 1982;139:1193--4.
67. Segraves RT. Reversal by bethanechol of imipramine-induced ejaculatory dysfunction. Am J Psychiatry 1987;144:1243--4


BETHANECOL CHLORIDE FOR TREATMENT OF CLOMIPRAMINE-INDUCED ORGASMIC DYSFUNCTION IN MALES - 2004
https://pdfs.semanticscholar.org/0862/9 ... 565956.pdf


Bethanechol-induced increase in hypothalamic estrogen receptor binding in female rats is related to capacity for estrogen-dependent reproductive behavior. - 1988
https://www.ncbi.nlm.nih.gov/pubmed/2900667/

"Neuroactive agents associated with different neurotransmitter systems can modulate the number of hypothalamic estrogen binding sites. It has been demonstrated previously that the muscarinic cholinergic agonist, bethanechol, administered 30 min prior to in vitro estrogen receptor assays increases the concentration of hypothalamic estrogen binding sites by 30-35% in female rats. Bethanechol was without effect on male hypothalamic preparations. In order to investigate further this sex difference and in an attempt to determine a relationship between the modulation of estrogen binding sites and a sexually differentiated function, bethanechol was given to female rats rendered either anovulatory and capable of displaying lordosis or anovulatory and behaviorally insensitive to estrogen. The results showed that bethanechol significantly increased the number of estrogen binding sites in females capable of displaying lordosis but not in females which did not show this estrogen-dependent behavior. It is possible that the capacity for drug-induced modulation of estrogen binding sites could be related functionally to the ability to display lordosis behavior."

[GIXXER]

Looks promising. Its sold as PMS relief medication here in Canada.

https://www.rexall.ca/articles/view/304 ... ethanechol

[CuredPSSD]

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[CuredPSSD]

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[anacleta]

is it possible to have the urologist's name in a private message?

[CuredPSSD]

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