Reversing silenced AR signal with demethylating agents - A promising treatment option?

[Dryed]

https://forum.propeciahelp.com/t/revers ... ption/3216

I invite everyone to take a read about how much step forward in knowledge are on propeciahelp and how much we can learn from them as we probably share the same etiology with pfs... And it's not only my statement

[Snake]

https://forum.propeciahelp.com/t/revers ... ption/3216

I invite everyone to take a read about how much step forward in knowledge are on propeciahelp and how much we can learn from them as we probably share the same etiology with pfs... And it's not only my statement

We were talking about it in the past too when we discovered that study concerning epigenetic changes caused by citalopram.

[Dryed]

Ops.. Sorry! Sometimes is hard to takes track of everything

[PsychoGenesis]

ive been on valproate + hydralazine for a month(logged on the oher forum too)
google pubmed for this combo, its being used in place of decitabine/azacytidine for demethylating cancer

+tenofovir(NRTI)

this should be all i needed for my genes to reset right??

also shot triptorelin few weeks ago to keep the hormones stable

[nasibi]

this should be all i needed for my genes to reset right??

Probably not.

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine

Previous studies have shown that EGCG, hydralazine, and procainamide are able to reduce DNA methylation and reactivate gene expression in cancer cells (15–21). We examined a total of six different genes/repetitive elements in three separate cell lines for their DNA methylation levels using quantitative Ms-SNuPE and pyrosequencing, and their mRNA expression levels by real-time reverse transcription-PCR and reverse transcription-PCR. Both the Ms-SNuPE and pyrosequencing results show that only the nucleoside analogue 5-Aza-CdR can very reliably reduce methylation in all three cell lines. All three non-nucleoside agents have much weaker, if any, demethylating activities, with procainamide being the only agent able to reduce DNA methylation of LINE elements in T24 cells.

In addition, we examined global methylation level changes with LINE and Alu repetitive elements and did not observe methylation inhibition from the non-nucleoside agents.

Taken together, our results do not support the idea that the three non-nucleoside agents tested are likely to be effective as epigenetic therapies with clinical or preventative actions.

http://mct.aacrjournals.org/content/4/10/1515.long