Anogeissus leiocarpus attenuates paroxetine-induced erectile dysfunction in male rats via.. 2019

[anacleta]

https://www.ncbi.nlm.nih.gov/m/pubmed/30841416/

Anogeissus leiocarpus attenuates paroxetine-induced erectile dysfunction in male rats via enhanced sexual behavior, nitric oxide level and antioxidant status.
Ademosun AO, et al. Biomed Pharmacother. 2019.
Authors
Ademosun AO1, Adebayo AA2, Oboh G2.
Author information
1Functional Foods and Nutraceutical Research Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure 340001, Nigeria. Electronic address: ayoademosun@yahoo.com.
2Functional Foods and Nutraceutical Research Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure 340001, Nigeria.
Citation
Biomed Pharmacother. 2019 Mar;111:1029-1035. doi: 10.1016/j.biopha.2019.01.022. Epub 2019 Jan 11.

Abstract
Sexual dysfunction is a side effect of the antidepressant drug paroxetine. Anogeissus leiocarpus is a medicinal plant with a wide range of biological activities which include antioxidant and antiulcer properties. With these in mind, we investigated the effect of Anogeissus leiocarpus stem bark extract on paroxetine-induced sexual dysfunction in male Wistar rats. Forty-two adult male Wistar rats were divided into seven experimental groups: normal control, PAR (10 mg/kg), PAR + sildenafil (5 mg/kg), ALE (50 and 100 mg/kg) and PAR + ALE (50 and 100 mg/kg). The experiment lasted for 21 days, after which the rats were subjected to sexual behavioral test. Various biochemical assays (phosphodiesterase-5, arginase, acetylcholinesterase, nitric oxide and MDA) were carried out on the penile tissue homogenate. From our findings, paroxetine significantly altered sexual behavior in male rats and increased phosphodiesterase-5, arginase and acetylcholinesterase activities with a concomitant decrease in nitric oxide level. Furthermore, paroxetine altered antioxidant status which revealed by increased MDA level and reduced thiol level. However, treatment with Anogeissus leiocarpus stem bark extract reversed the altered sexual behavior in male rats and boosted antioxidant status. In addition, administration of Anogeissus leiocarpus stem bark extract resulted in a significant attenuation of phosphodiesterase-5, arginase and acetylcholinesterase activities in paroxetine-induced rats. In view of the aforementioned findings, Anogeissus leiocarpus could be considered a promising natural agent in erectile dysfunction management.

Copyright © 2019. Published by Elsevier Masson SAS.
PMID 30841416 [Indexed for MEDLINE]