PSSD Forum

Meso wrote: ↑Tue Mar 23, 2021 6:27 pm Although I highly disagree with the notion that neurosteroids are involved in PSSD, since, unlike Paroxetine, many SRIs don't increase allopregnanolone yet still trigger full-blown PSSD. I still believe this study might be the window we need into getting PSSD more recognized within the research community and spark some interest in further research into the condition.

lukejimmy wrote: ↑Thu Jan 27, 2022 8:09 pm

Meso wrote: ↑Tue Mar 23, 2021 6:27 pm Although I highly disagree with the notion that neurosteroids are involved in PSSD, since, unlike Paroxetine, many SRIs don't increase allopregnanolone yet still trigger full-blown PSSD. I still believe this study might be the window we need into getting PSSD more recognized within the research community and spark some interest in further research into the condition.

Which SSRI doesn’t increase Allo. I dare anyone to read the allopregnanolone wiki and tell me it doesn’t describe in its effects, almost everything we complain about missing since Pre-Pssd. These symptoms i’m referring to are identical in PFS/PAS and guess what, Dr Melcangi and a few a other studies found undetectable Allopregnanolone levels in the CSF of PFS patients every single time. Remember SSRI’s are extremely potent at stimulating Allopregnanlone it’s not some insignificant side issue, it’s arguably what gives them there therapeutic effects.

It would also explain why SSRI reinstatement eliminates PSSD temporarily in the same way a Post-Benzo person with Post Acute Withdrawal Syndrome would eliminate their symptoms after reinstatement of the offending Benzo. (“ Therefore, it is possible to hypothesize that altered neurosteroidogenesis may also occur in PSSD and consequently it may represent a possible pharmacological target for this disorder.”)

I don’t know what the detailed results are of the study I’ve only read the abstract