Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

This is for hypothesis and even educated speculation.
CN9
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Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by CN9 »

Hello everyone,

I have no qualified knowledge on this field, so can anybody see a useful hypothesis behind the title?

Since my PSSD I suffer from bronchospasms after meals, expecially after fatty meals. After many years of suffering after every meal and the incompetence of many doctors, I tried salbutamol (aerosol spray) and it gave me a big relief from this constitution.
So I got me some ventolin (salbutamol as tabs, 8 mg per day). I'm not sure, if the agonism of the beta-2-receptors of my bronchial tubes was enough (by the spray) or if ventolin gave me an extra relaxation of my "feeling of tightness" but my heart palpitations and my Bronchitis or asthma, whatever it is, don't bother me anymore. Except for now, when I started eating daily beef jerkys (these ones: https://www.youtube.com/watch?v=c-LAqzSgneY ). After eating one, I get those feelings back, despite a 4 mg of salbutamol. Only the spray helps afterwards, but slight palpitations and a pressure on the chest remains. This took me to a quick google research, what made me also come here and ask you guys, if you see any connection to (my) pssd?

Tadalafil or sildenafil also don't really help with erections. #

I have high blood pressure, my sodium is at the lowest end, and my cholesterol is high.

What if the root cause of our pssd leads to a disfunction of metabolism of Nitrites and fats or what the f*ck ever!?

However, I'm sure, there is a connection between those symptoms, my weak erections (which got much better, although I can't tell really why), the feeling of less masculinity (although I lift very heavy and being a big guy (110 kg, 174 cm, upperarm of 50 cm, 290 kg deadlifts, 220 kg squats, ... and being natural from day one (germany natural)), less feeling pump, having disproportionate much belly fat since setraline, which I can't get rid off, fatty/oedematous skin at the limbs and belly, less urination (even if I drink... I used to urinate every 10 minutes, when I was very drunk... now, there is almost no change)...
I reinstated escitalopram last year in may, I experimented with different dosis (2,5; 5; 10; 15) for several month and since nov. 20 I took only 2,5 mg or even just 1,25 mg. I tapered off once for 2 weeks(?) and I'm drug-free for a week now... my belly fat became more aqueous again, and I feel like, my palpitations got more noticeable (but this can be due to being more alert than on a ssri.) ... however, what if there is a connection? Can we localise the serotonin receptor backwards by these symptoms?

Of course, this is only a spontaneous and lazy observation but I know, that we have many well educated guys here, who can probably explain all this with very less effort or... it leads to a valid theory.
Area1255_2021
Posts: 168
Joined: Sun Aug 15, 2021 4:45 pm

Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by Area1255_2021 »

CN9 wrote: Sun Aug 15, 2021 10:05 am Hello everyone,

I have no qualified knowledge on this field, so can anybody see a useful hypothesis behind the title?

Since my PSSD I suffer from bronchospasms after meals, expecially after fatty meals. After many years of suffering after every meal and the incompetence of many doctors, I tried salbutamol (aerosol spray) and it gave me a big relief from this constitution.
So I got me some ventolin (salbutamol as tabs, 8 mg per day). I'm not sure, if the agonism of the beta-2-receptors of my bronchial tubes was enough (by the spray) or if ventolin gave me an extra relaxation of my "feeling of tightness" but my heart palpitations and my Bronchitis or asthma, whatever it is, don't bother me anymore. Except for now, when I started eating daily beef jerkys (these ones: https://www.youtube.com/watch?v=c-LAqzSgneY ). After eating one, I get those feelings back, despite a 4 mg of salbutamol. Only the spray helps afterwards, but slight palpitations and a pressure on the chest remains. This took me to a quick google research, what made me also come here and ask you guys, if you see any connection to (my) pssd?

Tadalafil or sildenafil also don't really help with erections. #

I have high blood pressure, my sodium is at the lowest end, and my cholesterol is high.

What if the root cause of our pssd leads to a disfunction of metabolism of Nitrites and fats or what the f*ck ever!?

However, I'm sure, there is a connection between those symptoms, my weak erections (which got much better, although I can't tell really why), the feeling of less masculinity (although I lift very heavy and being a big guy (110 kg, 174 cm, upperarm of 50 cm, 290 kg deadlifts, 220 kg squats, ... and being natural from day one (germany natural)), less feeling pump, having disproportionate much belly fat since setraline, which I can't get rid off, fatty/oedematous skin at the limbs and belly, less urination (even if I drink... I used to urinate every 10 minutes, when I was very drunk... now, there is almost no change)...
I reinstated escitalopram last year in may, I experimented with different dosis (2,5; 5; 10; 15) for several month and since nov. 20 I took only 2,5 mg or even just 1,25 mg. I tapered off once for 2 weeks(?) and I'm drug-free for a week now... my belly fat became more aqueous again, and I feel like, my palpitations got more noticeable (but this can be due to being more alert than on a ssri.) ... however, what if there is a connection? Can we localise the serotonin receptor backwards by these symptoms?

Of course, this is only a spontaneous and lazy observation but I know, that we have many well educated guys here, who can probably explain all this with very less effort or... it leads to a valid theory.
The root cause of PSSD could be nNOS-nitric oxide dysfunction; it cuts off the signals to the hypothalamus, dampens/weakens/makes insignificant those networks - decreases Androgen sensitivity and cuts off normal function of Dopamine. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333763/) You need to get your salt levels up, take 1 teaspoon of Salt/Sodium per day; https://pubmed.ncbi.nlm.nih.gov/7510737/

...as far as Erections; add Pomegranate Juice to the Cialis. Drink Pomegranate juice (non-concentrate) 3-4 8 oz cups per day: https://pubmed.ncbi.nlm.nih.gov/27785815/
...It restores nNOS.
Also - Histamine is central in nNOS - it stimulates cAMP which regulates nNOS; PSSD is VERY STRONGLY a LOW histamine disorder...
...but you have to correct the deficit in nNOS proteins & nitric oxide signaling along with it or Histamine won't fire in the "right/correct" areas of the Brain/Penis.
Frog
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Joined: Sun Feb 24, 2019 2:37 pm
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Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by Frog »

Area1255_2021 wrote: Sun Aug 15, 2021 4:54 pm
CN9 wrote: Sun Aug 15, 2021 10:05 am Hello everyone,

I have no qualified knowledge on this field, so can anybody see a useful hypothesis behind the title?

Since my PSSD I suffer from bronchospasms after meals, expecially after fatty meals. After many years of suffering after every meal and the incompetence of many doctors, I tried salbutamol (aerosol spray) and it gave me a big relief from this constitution.
So I got me some ventolin (salbutamol as tabs, 8 mg per day). I'm not sure, if the agonism of the beta-2-receptors of my bronchial tubes was enough (by the spray) or if ventolin gave me an extra relaxation of my "feeling of tightness" but my heart palpitations and my Bronchitis or asthma, whatever it is, don't bother me anymore. Except for now, when I started eating daily beef jerkys (these ones: https://www.youtube.com/watch?v=c-LAqzSgneY ). After eating one, I get those feelings back, despite a 4 mg of salbutamol. Only the spray helps afterwards, but slight palpitations and a pressure on the chest remains. This took me to a quick google research, what made me also come here and ask you guys, if you see any connection to (my) pssd?

Tadalafil or sildenafil also don't really help with erections. #

I have high blood pressure, my sodium is at the lowest end, and my cholesterol is high.

What if the root cause of our pssd leads to a disfunction of metabolism of Nitrites and fats or what the f*ck ever!?

However, I'm sure, there is a connection between those symptoms, my weak erections (which got much better, although I can't tell really why), the feeling of less masculinity (although I lift very heavy and being a big guy (110 kg, 174 cm, upperarm of 50 cm, 290 kg deadlifts, 220 kg squats, ... and being natural from day one (germany natural)), less feeling pump, having disproportionate much belly fat since setraline, which I can't get rid off, fatty/oedematous skin at the limbs and belly, less urination (even if I drink... I used to urinate every 10 minutes, when I was very drunk... now, there is almost no change)...
I reinstated escitalopram last year in may, I experimented with different dosis (2,5; 5; 10; 15) for several month and since nov. 20 I took only 2,5 mg or even just 1,25 mg. I tapered off once for 2 weeks(?) and I'm drug-free for a week now... my belly fat became more aqueous again, and I feel like, my palpitations got more noticeable (but this can be due to being more alert than on a ssri.) ... however, what if there is a connection? Can we localise the serotonin receptor backwards by these symptoms?

Of course, this is only a spontaneous and lazy observation but I know, that we have many well educated guys here, who can probably explain all this with very less effort or... it leads to a valid theory.
The root cause of PSSD could be nNOS-nitric oxide dysfunction; it cuts off the signals to the hypothalamus, dampens/weakens/makes insignificant those networks - decreases Androgen sensitivity and cuts off normal function of Dopamine. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333763/) You need to get your salt levels up, take 1 teaspoon of Salt/Sodium per day; https://pubmed.ncbi.nlm.nih.gov/7510737/

...as far as Erections; add Pomegranate Juice to the Cialis. Drink Pomegranate juice (non-concentrate) 3-4 8 oz cups per day: https://pubmed.ncbi.nlm.nih.gov/27785815/
...It restores nNOS.
Also - Histamine is central in nNOS - it stimulates cAMP which regulates nNOS; PSSD is VERY STRONGLY a LOW histamine disorder...
...but you have to correct the deficit in nNOS proteins & nitric oxide signaling along with it or Histamine won't fire in the "right/correct" areas of the Brain/Penis.
Post edited to make clear that this is a hypothesis
Area1255_2021
Posts: 168
Joined: Sun Aug 15, 2021 4:45 pm

Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by Area1255_2021 »

Pomegranate works wonders along with Cialis!!!
Frog
Posts: 292
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Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by Frog »

Area1255_2021 wrote: Sun Aug 15, 2021 5:00 pm Pomegranate works wonders along with Cialis!!!
That’s great, I’m glad that it works for you however this is what I was referring to: “ The root cause of PSSD could be nNOS-nitric oxide dysfunction; it cuts off the signals to the hypothalamus, dampens/weakens/makes insignificant those networks - decreases Androgen sensitivity and cuts off normal function of Dopamine.”

You said that it was the root cause so I changed it to “could be” as no one knows the root cause
CN9
Posts: 77
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Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by CN9 »

kpavel wrote: Sun Aug 15, 2021 1:05 pm Belly fat is inversely associated to adiponectin levels.
https://pubmed.ncbi.nlm.nih.gov/20154470/
https://pubmed.ncbi.nlm.nih.gov/31159801/
https://pubmed.ncbi.nlm.nih.gov/31337827/
Adiponectin levels can be regulated by serotonin.
https://pubmed.ncbi.nlm.nih.gov/17097612/
https://pubmed.ncbi.nlm.nih.gov/18675814/
Metabolic problems badly influence male hormones
https://pubmed.ncbi.nlm.nih.gov/28225990/
A small example of quercetin benefits
https://pubmed.ncbi.nlm.nih.gov/31905615/
Thanks alot
you always bring up good ideas. Never heard of adiponectin, what makes me angry, thought I'm good at researching.
Last edited by CN9 on Mon Aug 16, 2021 2:21 pm, edited 1 time in total.
CN9
Posts: 77
Joined: Sun May 17, 2020 1:49 pm
Contact:

Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by CN9 »

Area1255_2021 wrote: Sun Aug 15, 2021 4:54 pm
CN9 wrote: Sun Aug 15, 2021 10:05 am Hello everyone,

I have no qualified knowledge on this field, so can anybody see a useful hypothesis behind the title?

Since my PSSD I suffer from bronchospasms after meals, expecially after fatty meals. After many years of suffering after every meal and the incompetence of many doctors, I tried salbutamol (aerosol spray) and it gave me a big relief from this constitution.
So I got me some ventolin (salbutamol as tabs, 8 mg per day). I'm not sure, if the agonism of the beta-2-receptors of my bronchial tubes was enough (by the spray) or if ventolin gave me an extra relaxation of my "feeling of tightness" but my heart palpitations and my Bronchitis or asthma, whatever it is, don't bother me anymore. Except for now, when I started eating daily beef jerkys (these ones: https://www.youtube.com/watch?v=c-LAqzSgneY ). After eating one, I get those feelings back, despite a 4 mg of salbutamol. Only the spray helps afterwards, but slight palpitations and a pressure on the chest remains. This took me to a quick google research, what made me also come here and ask you guys, if you see any connection to (my) pssd?

Tadalafil or sildenafil also don't really help with erections. #

I have high blood pressure, my sodium is at the lowest end, and my cholesterol is high.

What if the root cause of our pssd leads to a disfunction of metabolism of Nitrites and fats or what the f*ck ever!?

However, I'm sure, there is a connection between those symptoms, my weak erections (which got much better, although I can't tell really why), the feeling of less masculinity (although I lift very heavy and being a big guy (110 kg, 174 cm, upperarm of 50 cm, 290 kg deadlifts, 220 kg squats, ... and being natural from day one (germany natural)), less feeling pump, having disproportionate much belly fat since setraline, which I can't get rid off, fatty/oedematous skin at the limbs and belly, less urination (even if I drink... I used to urinate every 10 minutes, when I was very drunk... now, there is almost no change)...
I reinstated escitalopram last year in may, I experimented with different dosis (2,5; 5; 10; 15) for several month and since nov. 20 I took only 2,5 mg or even just 1,25 mg. I tapered off once for 2 weeks(?) and I'm drug-free for a week now... my belly fat became more aqueous again, and I feel like, my palpitations got more noticeable (but this can be due to being more alert than on a ssri.) ... however, what if there is a connection? Can we localise the serotonin receptor backwards by these symptoms?

Of course, this is only a spontaneous and lazy observation but I know, that we have many well educated guys here, who can probably explain all this with very less effort or... it leads to a valid theory.
The root cause of PSSD could be nNOS-nitric oxide dysfunction; it cuts off the signals to the hypothalamus, dampens/weakens/makes insignificant those networks - decreases Androgen sensitivity and cuts off normal function of Dopamine. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333763/) You need to get your salt levels up, take 1 teaspoon of Salt/Sodium per day; https://pubmed.ncbi.nlm.nih.gov/7510737/

...as far as Erections; add Pomegranate Juice to the Cialis. Drink Pomegranate juice (non-concentrate) 3-4 8 oz cups per day: https://pubmed.ncbi.nlm.nih.gov/27785815/
...It restores nNOS.
Also - Histamine is central in nNOS - it stimulates cAMP which regulates nNOS; PSSD is VERY STRONGLY a LOW histamine disorder...
...but you have to correct the deficit in nNOS proteins & nitric oxide signaling along with it or Histamine won't fire in the "right/correct" areas of the Brain/Penis.
Thanks, I will take that extra spoon of salt, but I'm irritated. I must already eat a lot salt, because of my fast food nutrition and if not fast food, it s the turkish kitchen, which Loves salt.
but let s see...

Won t take cialis at the moment, I get heartburn of it. Can't take it anymore. When I start eating healthy, I will try that combo.

I was suspecting low histamine too, because my house dust allergy isn t as present as before PSSD.
But If I take L Histidin, or SJW, my joint inflammations hurt too much. I have an ossification on my olecranon (bursitis?), what also got much worse after sertraline (4 weeks summer 2017). it was okay for years under escitalopram (2012 - 2016)... also other areas like both shoulders, knees, back/spine made Problems. it all happened in the gym on sertraline (very weak muscles too). It fucked up something really really bad.
I'm sure, if I didn t have taken sertraline, the erectile dysfunction and mild anhedonia I could have handled with the common stuff (inositol, l arginin, Forskolin, berberine, omega....) because I did to a acceptable degree but this feeling tightness, lack of being tired in a healthy way (being Able to sleep fast and or long), this lack of being able to daydream, fall in love, lack of feel time passing slow to relax and enjoy, that buzz from Alcohol, all this is due to setraline (and or paroxetine, which I Took 10 days long before setraline... but most of the remaining Symptoms I got from S. But who knows, perhaps it was the combination, that cold turkey of Paroxetine with Sertraline directly after...however)

I always thought, that an escitalopram induced PSSD can't be as complex and multifaceted as a PSSD induced by Sertraline or Paroxetine because they target much more Transmitters in a significant way. Setralines Dopaminergic effects were very present for me... or was it the sigma-receptor, which made me very talkactive and clear in my mind?! or a 5-ht receptor in a Different area of my brain, where escitaloprames SERT inhibition was too weak!?
Who also gets crazy about those questions????
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kpavel
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Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by kpavel »

CN9 wrote: Mon Aug 16, 2021 1:57 pm
kpavel wrote: Sun Aug 15, 2021 1:05 pm Belly fat is inversely associated to adiponectin levels.
https://pubmed.ncbi.nlm.nih.gov/20154470/
https://pubmed.ncbi.nlm.nih.gov/31159801/
https://pubmed.ncbi.nlm.nih.gov/31337827/
Adiponectin levels can be regulated by serotonin.
https://pubmed.ncbi.nlm.nih.gov/17097612/
https://pubmed.ncbi.nlm.nih.gov/18675814/
Metabolic problems badly influence male hormones
https://pubmed.ncbi.nlm.nih.gov/28225990/
A small example of quercetin benefits
https://pubmed.ncbi.nlm.nih.gov/31905615/
Thanks alot
you always bring up good ideas. Never heard of adiponectin, what makes me angry, thought I'm good at researching.
Thanks, I simply know about some things about ppar gamma and adiponectin for many years and I was really interested how to improve fat appearance on face.
Area1255_2021
Posts: 168
Joined: Sun Aug 15, 2021 4:45 pm

Re: Nitrite, Nitrite Oxidase, Ammonia, Gut, Bronchospasm...

Unread post by Area1255_2021 »

CN9 wrote: Mon Aug 16, 2021 2:01 pm
Area1255_2021 wrote: Sun Aug 15, 2021 4:54 pm
CN9 wrote: Sun Aug 15, 2021 10:05 am Hello everyone,

I have no qualified knowledge on this field, so can anybody see a useful hypothesis behind the title?

Since my PSSD I suffer from bronchospasms after meals, expecially after fatty meals. After many years of suffering after every meal and the incompetence of many doctors, I tried salbutamol (aerosol spray) and it gave me a big relief from this constitution.
So I got me some ventolin (salbutamol as tabs, 8 mg per day). I'm not sure, if the agonism of the beta-2-receptors of my bronchial tubes was enough (by the spray) or if ventolin gave me an extra relaxation of my "feeling of tightness" but my heart palpitations and my Bronchitis or asthma, whatever it is, don't bother me anymore. Except for now, when I started eating daily beef jerkys (these ones: https://www.youtube.com/watch?v=c-LAqzSgneY ). After eating one, I get those feelings back, despite a 4 mg of salbutamol. Only the spray helps afterwards, but slight palpitations and a pressure on the chest remains. This took me to a quick google research, what made me also come here and ask you guys, if you see any connection to (my) pssd?

Tadalafil or sildenafil also don't really help with erections. #

I have high blood pressure, my sodium is at the lowest end, and my cholesterol is high.

What if the root cause of our pssd leads to a disfunction of metabolism of Nitrites and fats or what the f*ck ever!?

However, I'm sure, there is a connection between those symptoms, my weak erections (which got much better, although I can't tell really why), the feeling of less masculinity (although I lift very heavy and being a big guy (110 kg, 174 cm, upperarm of 50 cm, 290 kg deadlifts, 220 kg squats, ... and being natural from day one (germany natural)), less feeling pump, having disproportionate much belly fat since setraline, which I can't get rid off, fatty/oedematous skin at the limbs and belly, less urination (even if I drink... I used to urinate every 10 minutes, when I was very drunk... now, there is almost no change)...
I reinstated escitalopram last year in may, I experimented with different dosis (2,5; 5; 10; 15) for several month and since nov. 20 I took only 2,5 mg or even just 1,25 mg. I tapered off once for 2 weeks(?) and I'm drug-free for a week now... my belly fat became more aqueous again, and I feel like, my palpitations got more noticeable (but this can be due to being more alert than on a ssri.) ... however, what if there is a connection? Can we localise the serotonin receptor backwards by these symptoms?

Of course, this is only a spontaneous and lazy observation but I know, that we have many well educated guys here, who can probably explain all this with very less effort or... it leads to a valid theory.
The root cause of PSSD could be nNOS-nitric oxide dysfunction; it cuts off the signals to the hypothalamus, dampens/weakens/makes insignificant those networks - decreases Androgen sensitivity and cuts off normal function of Dopamine. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333763/) You need to get your salt levels up, take 1 teaspoon of Salt/Sodium per day; https://pubmed.ncbi.nlm.nih.gov/7510737/

...as far as Erections; add Pomegranate Juice to the Cialis. Drink Pomegranate juice (non-concentrate) 3-4 8 oz cups per day: https://pubmed.ncbi.nlm.nih.gov/27785815/
...It restores nNOS.
Also - Histamine is central in nNOS - it stimulates cAMP which regulates nNOS; PSSD is VERY STRONGLY a LOW histamine disorder...
...but you have to correct the deficit in nNOS proteins & nitric oxide signaling along with it or Histamine won't fire in the "right/correct" areas of the Brain/Penis.
Thanks, I will take that extra spoon of salt, but I'm irritated. I must already eat a lot salt, because of my fast food nutrition and if not fast food, it s the turkish kitchen, which Loves salt.
but let s see...

Won t take cialis at the moment, I get heartburn of it. Can't take it anymore. When I start eating healthy, I will try that combo.

I was suspecting low histamine too, because my house dust allergy isn t as present as before PSSD.
But If I take L Histidin, or SJW, my joint inflammations hurt too much. I have an ossification on my olecranon (bursitis?), what also got much worse after sertraline (4 weeks summer 2017). it was okay for years under escitalopram (2012 - 2016)... also other areas like both shoulders, knees, back/spine made Problems. it all happened in the gym on sertraline (very weak muscles too). It fucked up something really really bad.
I'm sure, if I didn t have taken sertraline, the erectile dysfunction and mild anhedonia I could have handled with the common stuff (inositol, l arginin, Forskolin, berberine, omega....) because I did to a acceptable degree but this feeling tightness, lack of being tired in a healthy way (being Able to sleep fast and or long), this lack of being able to daydream, fall in love, lack of feel time passing slow to relax and enjoy, that buzz from Alcohol, all this is due to setraline (and or paroxetine, which I Took 10 days long before setraline... but most of the remaining Symptoms I got from S. But who knows, perhaps it was the combination, that cold turkey of Paroxetine with Sertraline directly after...however)

I always thought, that an escitalopram induced PSSD can't be as complex and multifaceted as a PSSD induced by Sertraline or Paroxetine because they target much more Transmitters in a significant way. Setralines Dopaminergic effects were very present for me... or was it the sigma-receptor, which made me very talkactive and clear in my mind?! or a 5-ht receptor in a Different area of my brain, where escitaloprames SERT inhibition was too weak!?
Who also gets crazy about those questions????
Yes its tricky because with SSRI's you might have high histamine in the blood or generally in the body but low in the Brain where it needs to be - always a possibilty...but you could have inflammation from other pathways - as well. Have you tried Turmeric/Curcumin extract for inflammation?
--> https://nootropicsdepot.com/curowhite-c ... t-tablets/
^ That one works REAL well! ;)
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