PSSD could be small fiber polyneuropathy
Posted: Sat Jan 08, 2022 10:20 pm
I am a sufferer but also fortunate enough to be a family member of a prominent immunologist and neurologist. I have studied my disease for over 2 years now. I am as certain as I can be that this is the cause.
These other theories involving persistent upregulation/downregulation of various serotonin receptors or serotonin-dopamine imbalances, or upstream or downstream dysregulation, or epigenetic based dysfunction of androgens don’t hold up to the science.
Small Fiber Polyneuropathy (SFP) explains everything:
1. Small fibers off the dorsal penile branch are very sensitive and first to be effected. Loss of some or all sensations will lead to decreased libido and erectile control.
2. SFP commonly leads to anhedonia and insomnia as these small fibers are very involved in regulating circadian rhythms and physical feedback to emotions.
3. SFP leads to changes in ability to feel anxious via dysautonomia (heartrate response, vasoconstriction/vasodilation).
4. SFP leads to control issues with blood flow leading to cold extremities including cold penis and scrotum.
5. SFP leads to dry skin/changes to sweating patterns, hair loss, skin sensations, brain zap like tingling.
The list goes on and on, but I will stop.
“Windows” occur when the remaining small fibers become overcharged and compensate for the decreased densities (mornings, during illnesses, etc.)
SFP testing at most facilities is inaccurate as you are compared to an average across all ages.
To confirm, get a double biopsy (ankle and thigh) at a place that has enough data to compare you to your age bracket and race. You will most likely find that you have neuropathy or are in the bottom 25%.
The cause is impossible to know. It could be as a result of autoimmune flare up after the immunosuppressant actions of SSRIs, or due to their direct toxicity with slow metabolizers.
These other theories involving persistent upregulation/downregulation of various serotonin receptors or serotonin-dopamine imbalances, or upstream or downstream dysregulation, or epigenetic based dysfunction of androgens don’t hold up to the science.
Small Fiber Polyneuropathy (SFP) explains everything:
1. Small fibers off the dorsal penile branch are very sensitive and first to be effected. Loss of some or all sensations will lead to decreased libido and erectile control.
2. SFP commonly leads to anhedonia and insomnia as these small fibers are very involved in regulating circadian rhythms and physical feedback to emotions.
3. SFP leads to changes in ability to feel anxious via dysautonomia (heartrate response, vasoconstriction/vasodilation).
4. SFP leads to control issues with blood flow leading to cold extremities including cold penis and scrotum.
5. SFP leads to dry skin/changes to sweating patterns, hair loss, skin sensations, brain zap like tingling.
The list goes on and on, but I will stop.
“Windows” occur when the remaining small fibers become overcharged and compensate for the decreased densities (mornings, during illnesses, etc.)
SFP testing at most facilities is inaccurate as you are compared to an average across all ages.
To confirm, get a double biopsy (ankle and thigh) at a place that has enough data to compare you to your age bracket and race. You will most likely find that you have neuropathy or are in the bottom 25%.
The cause is impossible to know. It could be as a result of autoimmune flare up after the immunosuppressant actions of SSRIs, or due to their direct toxicity with slow metabolizers.