Tree wrote: ↑Sun Apr 17, 2022 8:00 pm
I believe hormone/metabolic changes are downstream effects of sert loss. You reverse the sert inhibition and everything else will start to normalize.
Do we have any practical way to reverse SERT loss? I think evodiamine and berberine was tried by many
My theory is ssris causes permeant epigenetic changes to microrna which decreases sert expression. I believe we have to Inhibit gsk3b in the raphe preferably to reverse epigenetic changes and to upregulate sert expression. Lithium and valproic acid are gsk3b Inhibitors and substances I'm considering to try.