PSSD Forum

This has happend to me several times. After 3-4 days of therapeutic doses of dextroamphetamine and then stopping I get a PSSD window. I can sense smells better. My surroundings feels more real. I feel more fight or flight anxiety (which is better than social anhedonia). My attraction to women are revived. I can feel excitement and I am more social. Alcohol is also greatly enhanced. Both positive and negative effects. It seems very strange because if anything, it should cause temporary dopamine downregulation/kappa opioid activation and in turn less reward circutry response. Anyone have any idea why this might be happening? Or anyone felt the same?

I should add that it only lasts a day, maybe two. Microdoses of asprin (about 10-60 mg) have given simular effects, when I think about it. Low-dose aspirin upregulates tyrosine hydroxylase and increases dopamine production. Maybe I should try that again. Though it raises my social anxiety alot.

I get windows when I get off wellbutrin. Last Tine it held for zwei weeks then the effect was gone from one day to another.

Result of acute stress or rebound depression from amphetamine use. Contrary to what is said episodic depression is known to deepen emotions.

You can get windows everytime you touch you brain with meds. Starting or ending a med. All make changes in brain and take sometime to body balance it again.

Low-dose aspirin upregulates tyrosine hydroxylase and increases dopamine production in dopaminergic neurons: Implications for Parkinson’s disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401361/

Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine Hydroxylase in Dopaminergic Neurons after Treatment with Paroxetine but Not with Agomelatine in Male Rats

https://pubmed.ncbi.nlm.nih.gov/30678046/

I got i have same. Reason is that your gut is affected due to withdrawal and so your gut unable to produce regular neurotransmitter release something like that. May be less serotonin production helping this

I’m thinking it has more to do with downregulation of some receptors controlling tonic dopamine transmission. But what the hell do I know. I think the gut is really important though. It hasen’t worked for me since the last time I wrote about it. Maybe longer breaks are required.

bockemossen wrote: ↑Fri Sep 02, 2022 9:35 pmAfter 3-4 days of therapeutic doses of dextroamphetamine and then stopping I get a PSSD window

Your case sounds similar to these 3 people who cured themselves with amphetamine. Note that a couple say they experienced most improvement AFTER the drugs wore off:

https://www.reddit.com/r/pssdhealing/co ... s_stories/

Ed, zero libido, brain fog, etc to the severest extent. almost all gone Now after 2.5 weeks on [amphetamine]

So I’ve taken about 5 mg of Dextroamphetamine on and off periods for the past couple months, and it’s safe to say I am healed! I noticed gradual improvements throughout each week and finally have my thought process back to normal. I will note that while on the dext. genital numbness and lack of libido became very present, but would come back after a few days off of the med. I have no clue what this med did to fix me, but I assume that the other med had altered my brain chemistry so bad that I was unable to function.

During it I thought that I just had only made my pssd worse because I thought I downregulated the sex receptors. Well the next morning and 2 weeks after that I was still pretty horny while watching porn and my penile sensations were dramatically increased. I repeated the procedure (with the amphetamine) after a month and now I am even better.