Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

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Terabithia
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Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by Terabithia »

The following is not my work. The 30 page report is attached here https://we.tl/t-BhUOqZN5G8?src=dnl. The user claims to be cured.

ENDgame. PFS, PSSD, PRSD. - Estrogen Resistance - Read and get rid of it once and for all.

Today I will be sharing with you the theory I developed over a month of reading and researching for 14 hours a day. Is the time I spent on this relevant as to understanding it? Not really. Why did **I** specifically make these realisations? I happened to be at the right spot where certain similarities made themselves clear to me. That's it.

I am confident, there will not be a single person to try what is recommended in here and not get rid of their condition. I am confident because what I am recommending is the common factor across the **largest** collection of full recovery reports across syndromes in the online communities. I am confident because, by **deliberately** attempting what is recommended in here, I got rid of **all** of my symptoms in 2 weeks. What were my symptoms? The entire symptomatology of PSSD.

Depression, anxiety, anhedonia, apathy, 0 libido asexuality, completely numb genitals, muted orgasms, flaccid glans and painful erection, cognitive impairment, nonexistant memory, depersonalisation, pelvic floor dysfunctions,reduced ejaculatory volume and force, genital shrinkage, suicidal ideation, immune dysfunctions, smell/taste deterioration, dry skin, muscle and joint fatigue weakness and aches, all the main and auxiliary symptomatology as outlined by Healy in his official publication: [https://pubmed.ncbi.nlm.nih.gov/34719438/](https://pubmed.ncbi.nlm.nih.gov/34719438/)

I got it all after getting off escitalopram. Never in my life had I felt symptoms of this magnitude ever before.

99% of it is gone. This all happened because of following the logic I am outlining in this paper. I've had the same issues with only minor improvements for 8 months now. Within 2 weeks, most of it was eradicated. This is no chance.

And it **WILL** happen for everyone else.Read the whole thing from top to bottom. It is the only way to understand all the connections I'm making, and to see my points. I have backed everything up with a myriad of studies. I have found the exact same symptomatology in 2 separate settings, in both of which it is caused by the SAME issue.

99% of your questions will be answered either directly in the paper or by reading the cited literature. There is absolutely no way that one sees and reads the same things I have read and does not come to an EQUAL conclusion.

I urge all of you to read it all the way through. Don't read parts of it, that will confuse you. I have structured this in a way as to guide the reader through my own realisations, beginning from shallow links and leading to deeper, direct connections.

This is **it.** The prize winning shot, the end all for these conditions. And what is proposed is **simple, inexpensive, safe. With no long standing consequences.** It's something anyone can try.

I will answer as many questions posted below as I can, or direct you to the answers in the theory or literature.

Wetransfer link that contains the PDF with my theory: [https://we.tl/t-BhUOqZN5G8](https://we.tl/t-BhUOqZN5G8)

https://www.reddit.com/r/PSSD/comments/ ... ame=iossmf

Following post:

Full disclosure:

Dr. Healy's reply to my email:
"This is an elegant read and looks like a good candidate explanation for something but not for PSSD
Without nailing how genital numbness happens and how that gets fixed in place it looks like you are explained some ancillary rather than core features"
------------------

Yet, in my pdf I thoroughly explain how genital numbness happens and why it persists. In fact, it is the segment of my theory of which I am most proud of, because I recognise the extreme importance of this specific syndrome, and it is precisely the fact that my theory explains genital numbness and ties it across conditions with equal aetiology that makes me so confident about its truthfulness.

Thus, I do not understand his answer. The only way I can explain it would be that Dr. Healy did not read through my entire paper, and likely only glanced at a part of it.
HzeTmy
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by HzeTmy »

I'm coming off 1 year phytoestrogens from Gingko Biloba my sexuality went first to the roof felt like 50x viagras for a month but then slowly worsened me without even noticing. I was like on kind of steroids my balls were constantly aroused and at top of my scrotum. Slept for 4 hours and was feeling like a new born every wake up. Every tissue in my body was driven at 300% so phytoestrogens are definitely very strong and make changes, but honestly for that reason i became addicted on it. Be careful phytoestogens or estrogens will also store inside your adiposal tissue around your lower belly in seconds like a pregnant woman. Then my heavy keto diet, exercising and extreme sweat sessions like never before flooded my liver with my stored phytoestrogens. Losing weight fast coming off phytoestrogens is very risky and harmful to your body. I know it's powerful from my own experience. I sometimes think giving gingko a second try but the symptoms after i experienced was too extreme and i can't do this to my body again, it pre-ruined my body and AD gave me the rest. I believe estrogen can maximize every tissue in our body from skin to brain tissue. Maybe that can repair some sexual pathways back or not who knows ...

Ginkgo started to have effect on me after first 3 - 4 weeks relieved my anxiety, stress and gave me like 1000 erections i never experienced before with alot of load too maybe that extreme hypersexual switch effect made me addictive. My hypersexuality faded into negativity without realizing after but nothing compared to PSSD. I didn't wanted to fall back in my anxiety state, never stopped and enjoyed my gained weight, extreme success and memory in my work. I started on 120MG of high quality Ginkgo product and ended on like 240MG. 5 years of overwork, constant home stress with my dad, no friends, not eating meat and poor appetite. Ginkgo kicked in like a kind of steroid-stimulant-antidepressant and changed me totally i wasn't a human beign anymore. Even the affair with my stepmom was unusual for me and would never happen normally.

Once maybe i recover and write a book ...
Last edited by HzeTmy on Wed Feb 01, 2023 12:21 pm, edited 1 time in total.
HzeTmy
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by HzeTmy »

Found Something !!!

From your PDF : Both tst and estradiol supplementation was necessary to fully restore sexual function in castrated mice with no aromatase.

https://foodforbreastcancer.com/article ... inhibitors
Foods that increase aromatase are :
1. Alcohol
2. Beef
3. Grilled, BBQ'd or smoked meat or fish
4. Lamb


This reddit user had a window by eating Lamb look :
https://www.reddit.com/r/PSSD/comments/ ... are_button

Eating Lamb could make sense now ...
Terabithia
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by Terabithia »

It’s interesting that the estrogen resistance theory has been hinted at by many people before even in this forum. viewtopic.php?p=46475&hilit=estrogen#p46475

I think we should do our due diligence and brainstorm the best possible course of action to safely test this theory in the most scientifically backed manner. I’ll start off by asking the questions:

1. If the cause of our symptoms is indeed rooted in estrogen resistance, then what is the best possible way to reverse that and restore proper estrogenic functioning?

2. Can any improvements or additions be made on the example protocol outlined in the PDF?

3. Are there any natural or supplemental ways to sensitize estrogen receptors without committing to hormonal therapy?

4. Should the reverse be looked into where estrogen levels are intentionally crashed in an attempt to upregulate estrogenic functioning? What are the risks?

5. What are the potential uses for aromatase inducing substances such as green tea, ginkgo, ginseng, HOPS, beef, lamb, and substances that induce the CYP19 enzyme such as certain antibiotics.

6. What is the likelihood that altered liver functioning was the root cause in inducing the initial estrogen dominant state through an accumulation and increased circulation of toxic metabolites, xenobiotics and xenoestrogens?

The following excerpt contains the example protocol suggested although I highly recommend critically reading the entire PDF as it contains all the relevant information required.

“Men:
Because the HPGA operates on a negative feedback loop based on estrogenic activity, increases in Estradiol will inhibit secretion of GnRH and shut down the axis, leading to detrimental effects in fertility and production of androgen and other hormones. As a result, any increases in Estrogen need to be accompanied by a temporary replacement of androgens, along with maintenance of endogenous production in the testes. Intramuscular injections are the most dependable way to produce predictable effects and are necessitated. Testosterone is preferable as aromatization is desirable, but DHT can substitute it if need be. The ester of testosterone administered can vary but should be long-lasting to avoid the need of multiple daily injections. Doses will vary between patients but should be in the 120 to 200mg range for Testosterone and 500 to 1000iu of HCG, per week. These are TRT ranges. Estradiol administration will vary depending on amount and frequency necessary to produce recovery and minimise adverse effects. 2 to 4mg are good options for initial doses. Estradiol Ester should be of short to medium duration, to avoid averse reactions and control levels. Estradiol Benzoate or Valerate are good options. Treatment should be maintained until patient reports stability in recovery, ceased, and then followed by a clomiphene protocol to restore endogenous production and discontinue exogenous supplementation.
Example Protocol:
Estradiol Valerate(3mg) + Testosterone-Enanthate(150mg/week) + HCG(1000iu/week) Followed by: Clomiphene citrate 25 or 50mg ED or EOD depending on patient.
Additional options:
If TRT or injections need to be avoided, Mesterolone(Proviron) provides a good alternative for men. Mesterolone is a synthetic derivative of DHT. Mesterolone is taken orally, but is not metabolised in the liver, and thus liver toxicity is not a concern. Mesterolone binds to and activates the androgen receptor, with weaker androgenic potential than DHT. The main desirable effect of Mesterolone in this case will be its SHBG-binding property. Mesterolone has a very strong affinity for SHBG, potentially higher than DHT. Because of this, it will severely reduce the amount of Testosterone, DHT and Estradiol that are SHBG-bound. This increased amount in free levels of the above hormones will result in their increased activity. Thus mesterolone monotherapy is a viable alternative, but may not be as efficient as a full protocol.
Mesterolone can also be used in combination with TRT + hcg or HCG alone. Example protocols:
Mesterolone 50mg ED + 2000iu HCG per week + 2mg estradiol valerate

Women:
Disruption in menstrual cycle is to be expected. Increase in androgens should be avoided in women, but may provide an alternative pathway if initial protocols appear inefficient, as aromatisation of Testosterone may be preferable to direct increases in Estradiol. Treatment in women should consist of an initial period of IM-administered Estrogen monotherapy, followed by a single administration of low-dose Progesterone after 10 days and only after patient reports beneficial effects from repeated Estradiol treatment. Dosing protocol in women consists of initial doses of between 4 and 10mg and frequency of up to 3 times a week depending on single dose amount and response. If the effects of progesterone appear deleterious, progesterone should be stopped and not administered again. Single administration of a progesterone antagonist such as Mifepristone could demonstrate whether reductions in Progesterone levels facilitate sexual behaviour, and thus guide direction of treatment. However, prolonged use of Mifepristone is not advised, as it appears to increase concentrations of plasma Progesterone, and may have unpredictable effects upon discontinuation.
After recovery is stabilised, a clomiphene protocol should replace Estradiol injections for a period of time, before it is ceased as well. Dosage of Estradiol will also vary but will be equal or slightly higher than those in men. Dosage of progesterone needs to be determined depending on outcomes.
Another possible pathway is the concomitant administration of Estradiol and low-dose Testosterone, as it has also shown to lead to full restoration of sexual behaviours. This should only be tried if progesterone resulted in deleterious effects.“
fellow1
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by fellow1 »

Terabithia wrote: Wed Feb 01, 2023 5:41 pm
5. What are the potential uses for aromatase inducing substances such as green tea, ginkgo, ginseng, HOPS, beef, lamb, and substances that induce the CYP19 enzyme such as certain antibiotics.

Massive and widespread misconception here, most of the substances you mentioned DOWNREGULATE aromatase, despite their constituents being estrogenic to some extent. Just google '' EGCG/green tea aromatase pubmed'' or '' HOPS aromatase'' etc. You will see.
Hops also inhibit aromatase activity, which is linked to 8-PN.
https://pubs.acs.org/doi/10.1021/acs.chemrestox.8b00345
Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats
https://pubmed.ncbi.nlm.nih.gov/12065214/
Terabithia
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by Terabithia »

I should have been more precise in my wording and differentiated between estrogenic and aromatase inducing substances. As for green tea I was under that impression that that study was only in vitro.

The study I was looking at: https://academic.oup.com/jn/article/138 ... ogin=false
DJoke
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by DJoke »

This theory is one of the best approaches to PSSD healing I have ever read. It gives a lot of answeres and possible treatment plan. It should get more attention on this forum. It should be tested and proved whether it is wrong or not.
My estradiol levels after getting PSSD were: 73 pmol/l where norm is 40-161. It is in the range but I have field to experimentation. I was thinking for a long time to do TRT protocol + HCG. Probably I will convince my doctor to it despite my T is 21.98 nmol/l so it is in the range. I am not sure how to convince him to prescribe me Estradiol Valerate. Should I use Hops Extract instead? What would be more effective?
Thank you for your efforts, this paper is a peace of very good job. I hope it will work at least for some people here.
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garycooper
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by garycooper »

So we have created a discord group for people interested in testing this hypothesis, or if you have questions for Sweaty.

https://discord.gg/NdvE47MVAk


Edited the link - its working now.
prop
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by prop »

garycooper wrote: Sun Feb 05, 2023 2:19 pm So we have created a discord group for people interested in testing this hypothesis, or if you have questions for Sweaty.

https://discord.gg/NdvE47MVAk


Edited the link - its working now.
Discord should be discouraged, all the content is going to be memory-holed one day, did nobody learn from what happened to paxilprogress.org and solvepfs.com? Libraries full of detailed personal experiences and regimens that are now gone forever because the webmasters didn't feel like keeping them online.

Keep discussions to places that have stood the test of time, like this website, and Reddit, etc.
Archive of PSSD recovery stories: https://pssd.netlify.app/
DeepRacer
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Re: Sweaty_Literature_69 on Reddit Theory: Estrogen Resistance. With Response From Dr. Healy

Unread post by DeepRacer »

Sweaty completely ignores the sexual symptoms that you can experience while taking these medications. For example, if you're taking an antidepressant and you experience genital numbness and then you get off of it and are still experiencing genital numbness months after, he thinks these are two separate causes. This really doesn't make any sense in my mind.
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