There is strong clinical evidence that R-citalopram inhibits the antidepressant effect of escitalopram (Kennedy et al. 2006; Lepola et al. 2004; Llorca et al. 2005).
We here show that R-citalopram does not appear to directly affect the 5-HTExt-enhancing action of escitalopram at the hSERT, a key finding.
Further, the putative allosteric site may not be important for inhibition of hSERT by escitalopram, suggesting the involvement of alternative underlying phenomena
R-citalopram
Re: R-citalopram
I dont know the potential mechanisms or theory behind it. However I took escitalopram for years and therefore R-citalopram as part of that. I'm willing personally to try it.
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