PSSD Forum

Yes. Spyros thought people with PFS/PSSD/PAS had become "'estrogen resistant", which means high doses would not affect them like random people. Which explains why, in the scope of the theory, short-term high doses of E2 was not too dangerous.

Interesting. Did Spyros ever discontinue the E2 therapy or is he still taking it? I wonder if using something less invasive, like resveratrol for example, could help? As it can increase estrogen receptor beta activity while not disturbing the ERa subtype, the most concerning one.

Perhaps someone could use a combination of TRT with resveratrol to accomplish this? I would like to find an alternative path to just experimenting with straight up estradiol supplementation.

I've never taken estrogen directly, but I know it must be at least part of my personal problem considering my anxiety always seems to diminish while on aromatase inhibitors...albeit sometimes my libido is worse.

"Acute estradiol exposure in rodents increases 5HTT mRNA and protein levels (McQueen, Wilson, Sumner, & Fink, 1999; Sumner et al., 1999; Sumner et al., 2007) whereas chronic estradiol administration decreases 5HTT mRNA levels in monkeys."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253022/

"Yet our data shows that estrogen, at least when given acutely, inhibits the inhibitory effect of SSRIs on SERT function, which is not consistent with such a clinical effect."

"Our data show that progesterone, similar to estrogen, interferes with the ability of an SSRI to block SERT function. Progesterone however had no effect on basal SERT function."

https://www.nature.com/articles/npp200823

Probably not a cure but acute estrogen usage could provide symptom relief but long term use may worsen symptoms.