I haven't tried Inositol yet, but SJW from a specific brand is able to reverse my PSSD. This week I asked what the hypericin and hyperforin content was and the brand replied that it had 0.3% hypericin and practically no hyperforin. Which is odd as the usual recommendation is for high hyperforin SJWs like Perika.guacamo wrote: ↑Tue Apr 25, 2023 4:20 pm U can use myo or d chiro depending on what you like better or both, check on yourself. If u dont feel anything u can have several options as I pointed out in my post but in my opinion If you dont want you to spend fortune on supplements but if you have by any chance any leftovers then you can go like this (with the regimen you are on right now)= b5+b9+b3 and vit K, b5 around 500mg, b9 400ug~ and b3 25mg. The thing is do you feel anything either bad or good or you do not feel anything at all? If you do not feel anyting at all then approach would've need to be different. Also notice that my post is about buying every b vitamin, every singular b vitamin in individual bottle and then do try outs with what you wrote as starting point, not the end by itself. I would've reduce d chiro there is no point to take this much, 400mg is the highest that was mentioned in literature but I guess if it will work then 100mg will do the job as well (it does for me, but for me both inositols work great, just that i never had bad experience with d-chiro, while I crashed from myo before, but that has changed and both work well now). Increasing the dosage when things don't work on little dosage probably wont switch things anyway.
If you have these vitamins then add 500mg b5, b3 25mg, vit k 100-200% RDI, folic acid 400ug with what you already take. Do not take b6. If you have these then experiment with myo and d-chiro. The order matters, if you want to try this, take b3 and b9 last, vit k and b500 first, you may try this with and without TMG. (first without then try with if wont work)
I think I was misunderstood because those who wanted to try my idea out only bought TMG, biotin, inositol and vit A as a starting point and the idea was to then buy every b vitamin (except b6) and try different combos. I know that it might be costly to do it this way but there is no workaround it. Cost is dependend on where you buy it, just buy the standard version like folic acid not methylfolate etc. It probs cost like 60$ to do this but it is the best investment possible, most of the people already spend hundred of dollars for random supplements that had 0.000001% chance of working, I am 100% certain that PSSD is directly related to folate-methionine-transsulfuration pathway and it will eventually gonna work when we match other things that do not directly contribute to the said pathways but control the kinetics via indirect mechanisms (like inositol, NAD pool and intracellular calcium - which is controlled by vit D and K etc.).
I find this video https://www.youtube.com/watch?v=OPNdhBo6VFg explaining one carbon metabolism (folate cycle) in a way that may give a bit of information even for someone not very familiar with the topic, give it a shot, especially what the blonde lady says, THF kinetics is the most important here. Don't bother yourself with MTHFR polymorphisms.
For me nothing changed I still feel good.
I took SRRI and antipsychotics at the same time, so my experience may not be universal for the average PSSD sufferer.