Study: Endorphins in Male Impotence: Evidence for Naltrexone Stimulation of Erectile Activity in Patient Therapy

[lookingforacure]

Abstract

In the present study we evaluated whether naltrexone administration could stimulate sexual function in 30 male patients, ages 25 to 50 years, with idiopathic impotence of at least one year's duration and not of organic etiology. The patients received naltrexone (50 mg/day) or placebo, on a random basis for two weeks. Sexual performance, expressed as the number of full coitus/week, was assessed before (time 0) and during (on days 7 and 15) each treatment. The naltrexone therapy significantly increased the number of successful coitus compared to placebo after 7 and 15 days of treatment: improvement of sexual performance was evident in 11 out of the 15 treated patients. All the patients experienced a significant increase in morning and spontaneous full penile erections/week. No significant side effects were reported. Endocrine studies revealed no significant modification of plasma LH, FSH or testosterone by naltrexone, suggesting that the positive effect of the drug on sexual behavior was exerted at a central level. A two-month follow-up, at which time patients were off treatment, erectile capacity had returned to baseline in 10 patients, while five reported complete recovery of their sexual ability. We hypothesize that an alteration in central opioid tone is present in idiopathic impotence and is involved in the impairment of sexual behavior.

[Jazzmatazz]

This sounds interesting. I wonder if anybody with PSSD has tried it so far

[lookingforacure]

I have (before I knew about this study), and it helped me tremendously. See my post history.

[alteredhomeostasis]

Alteration in central opioid tone - love that.

It’s a cool technique, I bet a lot of us would benefit from a trial.

[lookingforacure]

I bet you a lot of you would too, that’s why I keep pushing this! But nobody seems to be paying attention to it…

[Impermanence]

I bet you a lot of you would too, that’s why I keep pushing this! But nobody seems to be paying attention to it…

But in your case you got cured With Naltrexone but you were also taking Sertraline in the same time right?

[lookingforacure]

That’s correct. I didn’t reinstate it, I was on it.

[Impermanence]

I bet you a lot of you would too, that’s why I keep pushing this! But nobody seems to be paying attention to it…

I think I'm gonna give a try. Maybe 50mg/day and see what happen.

[lookingforacure]

I would try with much lower doses first, I suspect they work better- if you look on Reddit low dose naltrexone, they explain how to mix it with water to create a solution. I’d recommend starting at 5 mg per night- just a suggestion.

[lookingforacure]

Or maybe 10 rather than 5, as that’s what helped me.