Re: 90% improvement with lithium carbonate 450 mg
Posted: Wed Feb 14, 2024 3:05 pm
hi, did it also reverse your shrinkage problem?
A forum dedicated to collaborative research into PSSD (Post-SSRI Sexual Dysfunction).
https://www.pssdforum.org/
I would say that lithium is much more than that... To this day, the exact mechanism by which lithium acts on the brain is unknown. We have a starting point but nothing exact. You referred to something in particular, depression but see, the topic refers exclusively to sexual damage caused by antidepressants.Maxin wrote: ↑Tue Feb 20, 2024 1:00 pm Lithium works to stabilize moods. This doesn’t mean that the mechanism for lithium helping those with pssd is because of its mood stabilizing effects. It’s a naturally occurring element. Lithium is needed to transport B12 and folate into the cells. This could be why some improve with methyl b12 and folate. But others don’t because they need more lithium to carry it into cells. Without proper b12 levels, using lithium you can deplete b12 even further.
What could be possible here, is that Lithium is a potent synergist and activator of b12 through the lithium trans cobalamin receptor enzyme. So it may have activated b12 stores or improved b12 function which would open up methylation pathways for sure.
Shrinking was a scary thing for me. My penis seemed to run out of blood. It felt like I was in a stressful situation where the body releases adrenaline and the vessels contract but I wasn't tense nor was I going through a stressful moment. When I took lithium the symptom of shrinkage went away although I had the same result with the reinstatement of the antidepressant fluvoxamine.
You’re missing my point. My mood stabilizing comment wasn’t in response to your post. Someone else was alluding to it working solely because of its mood stabilizing properties and I think that’s just a downstream effect. It depends on so much on methylation (and genetic mutations)what side effects are experienced or the severity.rengfreitas wrote: ↑Wed Feb 21, 2024 2:36 pmI would say that lithium is much more than that... To this day, the exact mechanism by which lithium acts on the brain is unknown. We have a starting point but nothing exact. You referred to something in particular, depression but see, the topic refers exclusively to sexual damage caused by antidepressants.Maxin wrote: ↑Tue Feb 20, 2024 1:00 pm Lithium works to stabilize moods. This doesn’t mean that the mechanism for lithium helping those with pssd is because of its mood stabilizing effects. It’s a naturally occurring element. Lithium is needed to transport B12 and folate into the cells. This could be why some improve with methyl b12 and folate. But others don’t because they need more lithium to carry it into cells. Without proper b12 levels, using lithium you can deplete b12 even further.
What could be possible here, is that Lithium is a potent synergist and activator of b12 through the lithium trans cobalamin receptor enzyme. So it may have activated b12 stores or improved b12 function which would open up methylation pathways for sure.
you are confusing some things.fellow1 wrote: ↑Thu Feb 08, 2024 11:06 amI used orotate for 2 months, I got worse after 1 week, but I kept taking it and this new WORSE state didn't improve after stopping lithium. When I say worse, I mean ED, libido and anhedonia. Lithium is inhibitory towards dopamine, why do you think it's used for bipolar or hypomania and why do you think there are hundreds reports of people getting sexual dysfunction from lithium. It seems to me you are looking for lab rats on this forum as you are just newly registered here. and you start posts from lithium, probably some another ''guru'' from reddit who ''figured out theory''.rengfreitas wrote: ↑Thu Feb 08, 2024 10:52 amHow many days did you use? What type of lithium and dosage?
In this field of experiences and uncertainties we must be more persistent. I felt some things but I kept it at low doses for 2 months and look at my experience. The usual doses for bipolar disorder that are capable of affecting cognition are 900mg to 1600mg. We are talking about low dose. I started with 450mg and stayed for 2 months and reduced. It needs to be tested. Even to base it on an opinion I have to ask if the person really tested it for a long time. 1x or 1 week for me is not a parameter.
exactly the same problem and same effect when I take escitalopram again.rengfreitas wrote: ↑Wed Feb 21, 2024 2:41 pmShrinking was a scary thing for me. My penis seemed to run out of blood. It felt like I was in a stressful situation where the body releases adrenaline and the vessels contract but I wasn't tense nor was I going through a stressful moment. When I took lithium the symptom of shrinkage went away although I had the same result with the reinstatement of the antidepressant fluvoxamine.
My goal has always been to stop fluvoxamine and not have the sexual effect. Whenever I stopped taking the antidepressant, the sexual damage appeared. The difference now is that I stopped the antidepressant, the sexual damage came, I took the lithium, the sexual damage disappeared and I removed the lithium and the sexual part remained intact. Thank God.
WTF are you talking about. Do your research. dopamine is one of the main mechanisms of erections, mainly through D2 receptors and interplay with oxytocin.Titeuf wrote: ↑Sat Mar 23, 2024 8:58 pmyou are confusing some things.fellow1 wrote: ↑Thu Feb 08, 2024 11:06 amI used orotate for 2 months, I got worse after 1 week, but I kept taking it and this new WORSE state didn't improve after stopping lithium. When I say worse, I mean ED, libido and anhedonia. Lithium is inhibitory towards dopamine, why do you think it's used for bipolar or hypomania and why do you think there are hundreds reports of people getting sexual dysfunction from lithium. It seems to me you are looking for lab rats on this forum as you are just newly registered here. and you start posts from lithium, probably some another ''guru'' from reddit who ''figured out theory''.rengfreitas wrote: ↑Thu Feb 08, 2024 10:52 am
How many days did you use? What type of lithium and dosage?
In this field of experiences and uncertainties we must be more persistent. I felt some things but I kept it at low doses for 2 months and look at my experience. The usual doses for bipolar disorder that are capable of affecting cognition are 900mg to 1600mg. We are talking about low dose. I started with 450mg and stayed for 2 months and reduced. It needs to be tested. Even to base it on an opinion I have to ask if the person really tested it for a long time. 1x or 1 week for me is not a parameter.
#1
Dopamine has no impact on erections
#2 Dopamine plays a role in motivation, it is the starter but it is not what gives you your libido or your pleasure. acetylcholine which is the exciter and noradrenaline which makes us feel fear, sexual desire and pleasure.
As for erections, they depend on the level of 5a-R which influences your DHT and Influence (INOS) the Inducer Nitric Oxide Synthase.
Acetylcholine uses the vagus nerve's efferent pathway for erection and to stimulate your glands and the afferent pathway for sensation from the penis to your central nervous system.
everyone talks about dopamine for libido but your vagus nerve is important in this story. If you have poor vagal tone, you may have sexual problems as well as pelvic floor and bladder, anal, etc.
For erections that come back when you take the antidepressant again, it's also because of 5a-R. Antidepressants( not all) increase levels of 5a-R which leads to higher levels of INOS.