PSSD in 2024 and beyond: Meso's thoughts
Posted: Wed Mar 27, 2024 9:04 pm
Hey guys and gals!
Please share this with others:
Thanks for being by my side all these years. I really appreciate your support.
I remember the old days 3-4 years ago when the only theory about PSSD was 5HT1A autoreceptor desensitization and some abnormal SNPs and random trials. We have come a long way since then. My thoughts for the future of PSSD are:
1- FMT, FMT, FMT. And then some more FMT.
2- Ibogaine, two deep trips.
3- Metformin (MUST be the XR version)
4- Hormones (E2 + AAS)
5- Daily Psilocybin low dose.
6- rTMS: normally prescribed one to the left DLPFC **PLUS** intermittent theta burst to the right DLPFC.
7- Epigenetic modification. Especially TET1 upregulation.
8- If all things fail, then deep brain stimulation (DBS) or even ECT if truly desperate (very bad idea, but there is that for a last-ditch one).
Indeed, we have come a long way. My theoretical work on PSSD is my crowning achievement and I'm proud of it. Unfortunately, I may not be able to finalize the 2nd study on PSSD due to life circumstances. Perhaps one day the puzzle would be solved. Cheers!
Please share this with others:
Thanks for being by my side all these years. I really appreciate your support.
I remember the old days 3-4 years ago when the only theory about PSSD was 5HT1A autoreceptor desensitization and some abnormal SNPs and random trials. We have come a long way since then. My thoughts for the future of PSSD are:
1- FMT, FMT, FMT. And then some more FMT.
2- Ibogaine, two deep trips.
3- Metformin (MUST be the XR version)
4- Hormones (E2 + AAS)
5- Daily Psilocybin low dose.
6- rTMS: normally prescribed one to the left DLPFC **PLUS** intermittent theta burst to the right DLPFC.
7- Epigenetic modification. Especially TET1 upregulation.
8- If all things fail, then deep brain stimulation (DBS) or even ECT if truly desperate (very bad idea, but there is that for a last-ditch one).
Indeed, we have come a long way. My theoretical work on PSSD is my crowning achievement and I'm proud of it. Unfortunately, I may not be able to finalize the 2nd study on PSSD due to life circumstances. Perhaps one day the puzzle would be solved. Cheers!