Metergoline - 5-ht1a antagonist

[Kinncrimson]

Hey nonesuch, thank you very much for this promising posts and this 2 very good studies... Please also keep this thread updated .... You are worried about homeostasis, but our homeostasis has already been changed, PSSD is our new homeostasis, and we absolutely want to change that, I think we would have to take this longterm.

My update: I am down to 7.5mg Mianserin now, in 1-2 weeks I'm off it completely.
Then my Metergoline experiment will be started.

[nonesuch]

Yeah you're right about that regarding homeostasis. I'll keep you updated, will be interesting to hear your experience!

[Kinncrimson]

Nonesuch, how is it going?
I will skip the Mianserin at friday.... then I have 6 months... No success for me

[north4]

https://www.ncbi.nlm.nih.gov/pubmed/8627567
Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan.
Abstract
The effects of three compounds with alpha-2 adrenoceptor antagonistic properties, mirtazapine (Org 3770; Remeron), mianserin and idazoxan, were measured on hippocampal noradrenergic and serotonergic transmission in freely moving rats by using microdialysis. Dihydroxyphenylacetic acid (DOPAC) was measured as a correlate of noradrenergic presynaptic activity. Infusing 1 microM tetrodotoxin decreased extracellular serotonin (5-HT) and DOPAC by 65 and 40%, respectively. 5-Hydroxytryptophan (25 mg/kg s.c.) increased extracellular 5-HT by 500%, whereas 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (0.5 mg/kg s.c.) decreased 5-HT release by 60%. Prazosin decreased 5-HT release to 60% of base-line in agreement with an alpha-1-mediated control of 5-HT transmission, whereas it increased DOPAC release with 80%. Both mirtazapine (2 and 5 mg/kg s.c.) and idazoxan (1 mg/kg s.c.) caused a rapid increase in DOPAC by up to 80%. Mianserin slowly increased DOPAC, reaching a maximal increase of 30 and 60% at 2 and 5 mg/kg s.c., respectively. Only mirtazapine caused a concurrent increase in 5-HT, reaching up to 80% above base-line within 60 min, whereas mianserin and idazoxan failed to change 5-HT levels significantly. Mirtazapine (5 mg/kg s.c.) only slightly affected DOPAC and homovanillic acid levels in the striatum, hardly affected 5-HT release, but clearly increased 5-hydroxyindole acetic acid. Thus, the antidepressants mirtazapine and mianserin markedly differ in their effects on noradrenergic and serotonergic transmission in vivo as measured with microdialysis in freely moving rats. These differences are explained by their different modulatory effects on noradrenergic transmission.


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https://en.wikipedia.org/wiki/Chronic_p ... n_syndrome
https://en.wikipedia.org/wiki/Pudendal_nerve

Prazosin, trade names Minipress, Vasoflex, Lentopres and Hypovase, is a sympatholytic drug used to treat high blood pressure, anxiety, and posttraumatic stress disorder (PTSD).[2][3] It is an α1-blocker which acts as an inverse agonist at alpha-1 adrenergic receptors.[4] These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine.[3] They are also found throughout the central nervous system

https://en.wikipedia.org/wiki/Vasoconstriction

test it(low doses start)... cant get it in germany(i dont will buy it in suspect stores)

[ssinus]

Prazosin, Doxazosin, Terazosin - all of these are alpha 1 blockers - yes it will make your penis hang a bit better but wont do anything with numbness and will cause more ED problems together with watery semen. I tried it couple of times when I was sick of this shrinkage which PSSD caused to me - but this is not a cure, so I would suggest to anyone who would like to try it to start with really low dose.

[Kinncrimson]

@Nonesuch/allblues
Can you give us an update please? How is your feeling with Metergoline, are there any improvements?

[siebs1122]

I recently tried metergoline for one week, two drops in the mourning. It did not do anything until the 5th day, then the effects kicked in. It was very potent for me, and I had many side effects. However, it helped PSSD significantly. Unfortunately, I developed severe twitches throughout my body the same day the benefits started. As a result, I discontinued it. Even after discontinuation, these twitches are still present and are getting worse. Be careful with D2 agonists, including metergoline.

[Kinncrimson]

Thanks for the report siebs.
Which symptoms did it help? (e.g. Brainfog, anhedonia, etc.)
How long ago was your last intake?
What were the side effects?
2 drops is a little amount, so everything will be fine again soon.
Have you also kept the positive effects or only the twitches?

[siebs1122]

Thanks for the report siebs.
Which symptoms did it help? (e.g. Brainfog, anhedonia, etc.)
How long ago was your last intake?
What were the side effects?
2 drops is a little amount, so everything will be fine again soon.
Have you also kept the positive effects or only the twitches?

Metergoline significantly helped with all aspects of PSSD, including brain fog, anhedonia, testicular atrophy, and sexual functioning. I would say 30-40% improvement for me, and I was only on it for one week.

My last intake was one week ago.

Side effects were paranoia, anxiety, restlessness, muscle twitches, decreased appetite, and increased sweating.

Yes, 2 drops is very small compared to what some people take. However, many of the studies show that 2 drops still has a strong clinical effect. I might have just been hypersensitive to it (I am with a lot of drugs) but 2 drops had an EXTREMELY potent effect on me, I felt very heavily drugged while I was on it.

So far, I have kept the positive effects after discontinuation. I have kept some of the negative ones as well, such as muscle twitching, decreased appetite, and increased sweating. It's strange, but ever since I developed PSSD, I keep all the benefits/side effects of all the drugs and supplements I take, even after discontinuation.

[Bigmum]

Any changes in libido?