5-ht theory and steroidogenesis [Coraggio's corner]
Posted: Sat Oct 08, 2016 12:03 pm
Hi everybody, this is my first topic here. Like Ghost I' m studing to become a doctor.
I'm 25 from Italy. I'm in pssd state since april after long use of citalopram at low doses.
I' ve read a lot about articles and discussions. I try to explain my hypotese about all our shitty condition:
1)First of all I think 5-ht receptor desensitation is true but I think also is only a part of the problem. I want to
add the problem is not only 5ht 1a desensitation but also a down regulation of SERT and Thryptophan Hydroxylase. So
what I think is we don' t have huge serotoninergic activity but a wrong qualitative firing of 5-ht neurons. Zero's researches about SERT expression are a good thing IMHO.
2)SSRI have something to do with steroidogenesis. In the first article below is explained how SSRI modulate CSN steroidogenesis
modulating GABA A activity ( well known to have inhibition action on all the brain ) and in the second article is shown how
SSRI inhibit aromatase activity, an enzime involved in sexual hormone conversion. Furthermore, like well explaned by
Area1255's articles, serotoninergic system is involved in HPA axis regulation by dirctly neurons firing activity. (I want to
stress is not all about testosterone, healthy persons can have a good sex life even if their T levels aren't huge). Hormones
themselves play a role in neurons modulating activity and receptor regulation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670606/
https://www.ncbi.nlm.nih.gov/pubmed/26162595
3)Like the most part of medicine, deductive only approch is very week so let's pass to empirical evidence we have obteined from forum user reports:
--> People with PFS( Post Finasteride Syndrome): people from propeciaHelp forum report a lot of sympotms included ours like no libido, erectile dysfunction,
genital anesthesia. Finasteride upsets steroidogenesis inhibiting Alfa-5 reductase type II and III . People from propecia can have hormanal
issue or not just like us but they have a big steroidogenesis imbalance for sure.
--> Licorice Root: some anecdotal success story is reported ( like dude on dr.bob site and another one of pssd.forumotion reported on remedyspot )
they are true story? I don't know but is sure Licorice root changes steroidogenesis expression. Glycyzzhiza glabra, the main costituent,
has a lot of actions about steroidogenesis: it inhibits 11-hydroxysteroid dehydrogenase so blocks the metabolism of cortisol, shuts down
the enzime responsable of aldosterone coversion and decreases testosterone synthesis.
In addition, a metabolite of Glycyrrhiza Glabra 18Beta-Glycyrrhetinic Acid was found to be a serotoninergic modulator:
http://link.springer.com/article/10.100 ... 016-1938-5.
Licorice root could be a way to get out from pssd like reported. But prolonged high cortisol levels can lead to a permanent hypertension
and anti-hypertensive drugs are known to induce sexual dysfunction(especially ED).In fact, Licorice Root is found to mantain hypertension
after licorice suspension with a not well known pseudoaldosteronism.
--> Antimycotics: some reports claim improving after Fluconazole use. Why? we don' t konw. But Fluconazole changes normal steroidogenesis: It can low
cortisol and aldosterone through enzime conversion inhibition. It is used to treat Cushing off-label. One guy from Propeciahelp cure himself
with a prolonged therapy eith nystatin, Fluconazole and other antimycotics. Continue' s report says one of his friend is cured with 9 month of
nystatin. we must to get more info from him.
I'm 25 from Italy. I'm in pssd state since april after long use of citalopram at low doses.
I' ve read a lot about articles and discussions. I try to explain my hypotese about all our shitty condition:
1)First of all I think 5-ht receptor desensitation is true but I think also is only a part of the problem. I want to
add the problem is not only 5ht 1a desensitation but also a down regulation of SERT and Thryptophan Hydroxylase. So
what I think is we don' t have huge serotoninergic activity but a wrong qualitative firing of 5-ht neurons. Zero's researches about SERT expression are a good thing IMHO.
2)SSRI have something to do with steroidogenesis. In the first article below is explained how SSRI modulate CSN steroidogenesis
modulating GABA A activity ( well known to have inhibition action on all the brain ) and in the second article is shown how
SSRI inhibit aromatase activity, an enzime involved in sexual hormone conversion. Furthermore, like well explaned by
Area1255's articles, serotoninergic system is involved in HPA axis regulation by dirctly neurons firing activity. (I want to
stress is not all about testosterone, healthy persons can have a good sex life even if their T levels aren't huge). Hormones
themselves play a role in neurons modulating activity and receptor regulation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670606/
https://www.ncbi.nlm.nih.gov/pubmed/26162595
3)Like the most part of medicine, deductive only approch is very week so let's pass to empirical evidence we have obteined from forum user reports:
--> People with PFS( Post Finasteride Syndrome): people from propeciaHelp forum report a lot of sympotms included ours like no libido, erectile dysfunction,
genital anesthesia. Finasteride upsets steroidogenesis inhibiting Alfa-5 reductase type II and III . People from propecia can have hormanal
issue or not just like us but they have a big steroidogenesis imbalance for sure.
--> Licorice Root: some anecdotal success story is reported ( like dude on dr.bob site and another one of pssd.forumotion reported on remedyspot )
they are true story? I don't know but is sure Licorice root changes steroidogenesis expression. Glycyzzhiza glabra, the main costituent,
has a lot of actions about steroidogenesis: it inhibits 11-hydroxysteroid dehydrogenase so blocks the metabolism of cortisol, shuts down
the enzime responsable of aldosterone coversion and decreases testosterone synthesis.
In addition, a metabolite of Glycyrrhiza Glabra 18Beta-Glycyrrhetinic Acid was found to be a serotoninergic modulator:
http://link.springer.com/article/10.100 ... 016-1938-5.
Licorice root could be a way to get out from pssd like reported. But prolonged high cortisol levels can lead to a permanent hypertension
and anti-hypertensive drugs are known to induce sexual dysfunction(especially ED).In fact, Licorice Root is found to mantain hypertension
after licorice suspension with a not well known pseudoaldosteronism.
--> Antimycotics: some reports claim improving after Fluconazole use. Why? we don' t konw. But Fluconazole changes normal steroidogenesis: It can low
cortisol and aldosterone through enzime conversion inhibition. It is used to treat Cushing off-label. One guy from Propeciahelp cure himself
with a prolonged therapy eith nystatin, Fluconazole and other antimycotics. Continue' s report says one of his friend is cured with 9 month of
nystatin. we must to get more info from him.