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anacleta
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BUPROPION & PSSD: experiences

Unread post by anacleta »

http://en.wikipedia.org/wiki/Bupropion

"its mechanism of action is only partly understood. It has been widely described as a weak norepinephrine-dopamine reuptake inhibitor."
"is a non-competitive antagonist of neuronal nicotinic acetylcholine receptors"

Bupropion (Wellbutrin, Zyban ...) is a typical antidote used by psychiatrists to counteract the sexual side effects of SSRIs.

have you tried it? what results you got?



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My experience: I took it (with name Elontril) for some months, prescribed by my psychiatrist, for PSSD. Apparently, it did not give me any side effects nor antidepressant. When I, after a first half to 150 mg per day, I increased the dose to 300 mg, I have seen a significant improvement, which lasted for a few days only. I would have said a return of my sexuality to about 70%! for a couple of days I had again the ability to feel aroused and I masturbated 10 times in a day easily. However, in a few days the effect is decreased, and then disappear altogether.

Current situation: I do not took it for several more months, and I can not in any way feel horny, I difficultly have weak sensations of clitoral arousal. I have an active sex life. I believe that if I were a man I would not have an erection. I, despite NO sexual arousal and NO real pleasure, I can still reach orgasm with masturbation. But it is really very frustrating, I say forced, and NOT fulfilling.

It makes sense if I try to take 150 mg of bupropion before sexual intercourse? how long before sex is ideal?
Blackout
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Re: BUPROPION & PSSD: experiences

Unread post by Blackout »

I just opened a topic about my negative findings about bupropion and their relation with the apparent side effects it had on me -only that I became aware of them recently-. It may have been right to put it here, but I hadn't seen your thread until now.


Bupropion initially it made me feel slightly more motivated, alert and focused, with no improvement on PSSD, but any good effect faded over a couple of weeks later. It seems that bupropion desensitizes de 5-HT1A autoreceptor, according to the study that I found. Link: http://www.ncbi.nlm.nih.gov/pubmed/18708076

Abstract:
Bupropion is widely used in the treatment of depression. There are, however, limited data on its long-term effects on monoaminergic neurons and therefore the mechanism of its delayed onset of action is at present not well understood. The present study was conducted to examine the effects of prolonged bupropion administration on the firing activity of dorsal raphe nucleus (DRN), locus coeruleus (LC), and ventral tegmental area (VTA) neurons. Spontaneously firing neurons were recorded extracellularly in rats anesthetized with chloral hydrate. Bupropion (30 mg/kg/day) was administered using subcutaneously implanted minipumps. In the DRN, the firing rate of serotonin (5-HT) neurons was significantly increased after 2, 7 and 14 days of administration. The suppressant effect of LSD was significantly diminished after the two-day regimen, indicating a desensitization of 5-HT1A autoreceptors. In the LC, the firing rate of norepinephrine (NE) neurons was significantly attenuated after a 2-day regimen, but recovered progressively over 14 days of administration. The suppressant effect of clonidine on NE neuronal firing was significantly attenuated in rats treated with bupropion for 14 days, indicating a desensitization of alpha2-adrenoceptors. In the VTA, neither 2 nor 14 days of bupropion administration altered the firing and burst activity of dopamine neurons. These results indicate that bupropion, unlike 5-HT reuptake inhibitors, promptly increased 5-HT neuronal activity, due to early desensitization of the 5-HT1A autoreceptor. The gradual recovery of neuronal firing of NE neurons, due to the desensitization of alpha2-adrenoceptors, in the presence of the sustained increase in 5-HT neuronal firing, may explain in part the delayed onset of action of bupropion in major depression.
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anacleta
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Re: BUPROPION & PSSD: experiences

Unread post by anacleta »

Yesterday I took 150 mg of bupropion, hoping it would open a small window of improvement as a few hours after I had sex, instead nothing.

Maybe I should try it with 300 mg, but I have a little afraid to take that dose from scratch.
sraven
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Re: BUPROPION & PSSD: experiences

Unread post by sraven »

It can take two weeks or longer for the bupropion to kick in. Don't take the higher dose immediately; stay with the 150 for a week, then taper up. 200 for a week, then 300. You won't see much effect until the dose is up to 300.
elkikko

Re: BUPROPION & PSSD: experiences

Unread post by elkikko »

no one has tried wellbutrin?
I'm going to buy after buspar if it doesnt help me ...
lavos1
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Re: BUPROPION & PSSD: experiences

Unread post by lavos1 »

I took 300mg Wellbutrin for about six months in 2014--mostly for depression, but also with the hopes that it would boost my sexual functioning.
In general, it didn't do much of anything besides make me feel kind of jittery. YMMV, I suppose
elkikko

Re: BUPROPION & PSSD: experiences

Unread post by elkikko »

So, you have erectile disfunction but libido?
Use cialis for sex and you are recovered!!!
ryandaking
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Re: BUPROPION & PSSD: experiences

Unread post by ryandaking »

I was on bupropion 450mg a day for 2yrs for depression and PSSD due to Remeron discontinuation. I'd say it had marginal impact on sexual function. Maybe 10-15% improvement. I've recently transitioned off bupropion in order to rule out the norepinephrine effects. It's been 3wks and my erections are slightly improved but the numbness and anorgasmia have worsened a bit.
elkikko

Re: BUPROPION & PSSD: experiences

Unread post by elkikko »

Only 15%?
ryandaking
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Re: BUPROPION & PSSD: experiences

Unread post by ryandaking »

guest - deleted wrote:Only 15%?
Roughly speaking. It's not consistent. Sometimes it's better than others. Like a signal that is stronger. I never know until I'm in the moment. But it's always a struggle.
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